Results 61 to 70 of about 38,775 (145)
Pan-cancer analysis of the prognostic and immunological role of hippo-YAP signaling pathway
Discover OncologyThe Hippo-Yes-associated protein (Hippo-YAP) signaling pathway, a conserved pathway that regulates organ size, participates in tumor progression. However, there are few comprehensive analyses of tumor prognosis and immunity.
Jing Yang +5 more
doaj +1 more source
How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases
Journal of Immunology Research, 2018 Cardiovascular disease remains the leading cause of death around the globe. Cardiac deterioration is associated with irreversible cardiomyocyte loss. Understanding how the cardiovascular system develops and the pathological processes of cardiac disease ...
Wenyi Zhou, Mingyi Zhao
doaj +1 more source
A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis
Cell Reports, 2020 Summary: The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored.
Lingli He +17 more
doaj +1 more source
Expression of hippo pathway in colorectal cancer
Saudi Journal of Gastroenterology, 2014 Hippo pathway plays a crucial role in cell proliferation, apoptosis, and tumorigenesis. This study aimed to investigate the expression of Hippo pathway components in the progression and metastasis of colorectal cancer (CRC).Quantitative real-time polymerase chain reaction (qRT-PCR) was used to examine the mRNA expression levels of MST1, LATS2, YAP, TAZ,
Kun Liang +4 more
openaire +3 more sources
A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft Tissue Sarcomas
Frontiers in Oncology, 2015 The Hippo signaling pathway is an evolutionarily conserved developmental network vital for the regulation of organ size, tissue homeostasis, repair and regeneration, and cell fate. The Hippo pathway has also been shown to have tumor suppressor properties.
Michael D Deel +6 more
doaj +1 more source
PLoS ONE, 2013 Alcohol-mediated cancers represent more than 3.5% of cancer-related deaths, yet how alcohol promotes cancer is a major open question. Using Drosophila, we identified novel interactions between dietary ethanol and loss of tumor suppressor components of ...
Anoj Ilanges +3 more
doaj +1 more source
Interaction of noncoding RNAs with hippo signaling pathway in cancer cells and cancer stem cells
Non-coding RNA ResearchThe Hippo signaling pathway has a regulatory function in the organogenesis process and cellular homeostasis, switching the cascade reactions of crucial kinases acts to turn off/on the Hippo pathway, altering the downstream gene expression and thereby ...
Saba Abedimanesh +9 more
doaj +1 more source
Phosphatidic acid: a lipid regulator of the Hippo pathway
Molecular & Cellular Oncology, 2019 The Hippo pathway, a signaling pathway highly conserved across species, plays a crucial role in organ size control and cancer suppression. Our recent study shows that phosphatidic acid can regulate the Hippo pathway through a physical lipid-protein ...
Han Han +3 more
doaj +1 more source
Hippo Pathway in Cancer, towards the Realization of Hippo-Targeted Therapy [PDF]
Cancers, 2018 n ...
openaire +2 more sources
GPCR-Hippo Signaling in Cancer
Cells, 2019 The Hippo signaling pathway is involved in tissue size regulation and tumorigenesis. Genetic deletion or aberrant expression of some Hippo pathway genes lead to enhanced cell proliferation, tumorigenesis, and cancer metastasis. Recently, multiple studies
Jiaqian Luo, Fa-Xing Yu
doaj +1 more source