Results 31 to 40 of about 38,905 (162)
The dark side of hippo signaling: A cancer promoter role
Fly, 2017 The Hippo signaling pathway regulates organ size and tissue homeostasis. Given this role it is unsurprising that dysregulation of this pathway has implications for cancer progression.
Brandon Dunn, Xianjue Ma
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The role of non-canonical Hippo pathway in regulating immune homeostasis
European Journal of Medical Research, 2023 The Hippo pathway is a crucial signaling pathway that is highly conserved throughout evolution for the regulation of organ size and maintenance of tissue homeostasis.
Dagang Tang, Huan Xu, Xing Du
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The role of Hippo pathway in ferroptosis
Frontiers in Oncology, 2023 The role of Hippo pathway in ferroptosisThe Hippo pathway is mainly composed of mammalian serine/threonine (Ste20)like kinases 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and transcriptional coactivator Yes-associated protein (YAP), and is closely related to cell growth, survival, proliferation, and migration; tissue and organ size control; and
Jiangxia Xiang +3 more
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Clinical and biological implications of Hippo pathway dysregulation in sarcomas
Forum of Clinical Oncology, 2019 Sarcomas are mesenchymal malignant tumors with poor prognosis and limited treatment options. Hippo pathway is a recently discovered pathway normally involved in organ development and wound healing. Hippo signaling is often altered in solid tumors.
Kyriazoglou Anastasios +4 more
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Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View
Frontiers in Cell and Developmental Biology, 2021 Initially identified in Drosophila, the Hippo signaling pathway has emerged as an evolutionarily conserved tumor suppressor pathway that controls tissue growth and organ size by simultaneously inhibiting cell proliferation and promoting cell death ...
Yong Suk Cho, Jin Jiang, Jin Jiang
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Scribble acts in the Drosophila fat-hippo pathway to regulate warts activity. [PDF]
PLoS ONE, 2012 Epithelial cells are the major cell-type for all organs in multicellular organisms. In order to achieve correct organ size, epithelial tissues need mechanisms that limit their proliferation, and protect tissues from damage caused by defective epithelial ...
Shilpi Verghese +4 more
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E2 enzyme Bruce negatively regulates Hippo signaling through POSH-mediated expanded degradation
Cell Death and Disease, 2023 The Hippo pathway is a master regulator of organ growth, stem cell renewal, and tumorigenesis, its activation is tightly controlled by various post-translational modifications, including ubiquitination.
Sha Song, Xianjue Ma
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Microbiology Spectrum, 2023 White spot syndrome virus (WSSV) is a serious threat to shrimp aquaculture, especially Pacific white shrimp, Penaeus vannamei, the most farmed shrimp in the world.
Linwei Yang +8 more
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Spectrin regulates Hippo signaling by modulating cortical actomyosin activity
eLife, 2015 The Hippo pathway controls tissue growth through a core kinase cascade that impinges on the transcription of growth-regulatory genes. Understanding how this pathway is regulated in development remains a major challenge.
Hua Deng +5 more
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The Hippo-p53 pathway in megakaryopoiesis
Haematologica, 2016 Megakaryocytes are among the largest and rarest cells in the body, accounting for approximately 0.01% of nucleated cells in the bone marrow. Their differentiation involves a progression from hematopoietic stem cell to the megakaryocyte progenitor and finally to platelets.[1][1] A key step in ...
Praveen K Suraneni, John D. Crispino
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