Results 31 to 40 of about 67,151 (262)

USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis

Cell Death and Disease, 2023
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. The Hippo signaling pathway has emerged as a significant suppressive pathway for hepatocellular carcinogenesis.
Dongyi Liu, Quanhui Li, Yifeng Zang, Xin Li, Zhongbo Li, Peng Zhang, Chang Feng, Penghe Yang, Jiayao Cui, Yanan Sun, Tian Wei, Peng Su, Xin Zhao, Huijie Yang, Yinlu Ding   +14 more
doaj   +1 more source

The Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response

Frontiers in Immunology, 2022
The Hippo pathway was initially discovered in Drosophila melanogaster and mammals as a key regulator of tissue growth both in physiological and pathological states. Numerous studies depict the vital role of the Hippo pathway in cardiovascular development,
Ancheng Zheng, Qishan Chen, Li Zhang
doaj   +1 more source

Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell [PDF]

, 2012
During the primary response, the commitment of the CD8(+) T cell to Blimp-1 expression and the terminal differentiation that Blimp-1 induces must be timed so as not to impair the process of clonal expansion. We determined whether the Hippo pathway, which
A. Hoffmann, Bachmann, Bachmann, Bachmann, Bannard, Camargo, Chai, Choi, Cretney, D. T. Fearon, Dong, Feau, Gong, H. Lingel, Harrington, Hegel, J. E. D. Thaventhiran, Kalia, Kallies, Katagiri, Khanna, Kwon, L. Magiera, Lee, M. Brunner-Weinzierl, M. de la Roche, Nishioka, Pearce, Pipkin, Rao, Russ, Rutishauser, Sabatos, Schlegelmilch, Sun, Taylor, Turner, Voehringer, Waterhouse, Williams, Yeo, Zhao, Zhou   +42 more
core   +1 more source

Okadaic Acid: A Tool to Study the Hippo Pathway

Marine Drugs, 2013
Mammalian Ste20-like kinases 1 and 2 (MST1 and MST2) are activated in NIH3T3 cells exposed to okadaic acid. The Hippo pathway is a newly emerging signaling that functions as a tumor suppressor.
Yutaka Hata, Sainawaer Maimaiti, Shikshya Timalsina   +2 more
doaj   +1 more source

Targeting Hippo signaling in cancer: novel perspectives and therapeutic potential

MedComm, 2023
As highly conserved among diverse species, Hippo signaling pathway regulates various biological processes, including development, cell proliferation, stem cell function, tissue regeneration, homeostasis, and organ size.
Liemei Lv, Xiangxiang Zhou
doaj   +1 more source

The Hippo pathway: regulators and regulations [PDF]

Genes & Development, 2013
Control of cell number is crucial in animal development and tissue homeostasis, and its dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in both Drosophila and mammals regulates cell number by modulating cell proliferation, cell death, and cell differentiation.
Fa-Xing, Yu, Kun-Liang, Guan
openaire   +2 more sources

Hippo dictates signaling for cellular homeostasis and immune defense in Crassostrea hongkongensis hemocytes

Frontiers in Immunology, 2023
IntroductionThe Hippo signaling pathway is an evolutionarily conserved signaling cascade that plays a crucial role in regulating cell proliferation, differentiation, and apoptosis.
Fan Mao, Fan Mao, Xiaoying Zheng, Xiaoying Zheng, Nai-Kei Wong, Wenjie Yi, Wenjie Yi, Jingchen Song, Jingchen Song, Jingchen Song, Shiwei Fu, Shiwei Fu, Shiwei Fu, Zhiming Xiang, Zhiming Xiang, Shu Xiao, Shu Xiao, Yongbo Bao, Ziniu Yu, Ziniu Yu, Yang Zhang, Yang Zhang   +21 more
doaj   +1 more source

Glucocorticoid receptor signalling activates YAP in breast cancer [PDF]

, 2017
The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activation of the transcription co-activator YAP ...
Bertolio, Rebecca, Bicciato, Silvio, Cappuzzello, Elisa, Del Sal, Giannino, Forcato, Mattia, Ingallina, Eleonora, Mano, Miguel, Marotta, Carolina, Neri, Carmelo, Rosato, Antonio, Ruggeri, Naomi, Sorrentino, Giovanni, Zannini, Alessandro   +12 more
core   +3 more sources

Mechanisms of Hippo pathway regulation

Genes & Development, 2016
The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue growth two decades ago and has been a subject extensively studied in both Drosophila and mammals in the last several years.
Meng, Zhipeng, Moroishi, Toshiro, Guan, Kun-Liang   +2 more
openaire   +4 more sources

The dark side of hippo signaling: A cancer promoter role

Fly, 2017
The Hippo signaling pathway regulates organ size and tissue homeostasis. Given this role it is unsurprising that dysregulation of this pathway has implications for cancer progression.
Brandon Dunn, Xianjue Ma
doaj   +1 more source