Results 231 to 240 of about 2,495,395 (314)

Matrix games between full siblings in Mendelian populations. [PDF]

PLoS One
Garay J, Varga T, Csiszár V, Móri TF, Szilágyi A.   +4 more
europepmc   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

Optimal strategies in fractional games: vertex cover and domination

Csilla Bujtás, Günter Rote, Źsolt Tuza   +2 more
openalex   +2 more sources

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

Advanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi, Qi‐Long Tang, Jin‐Hong Wang, Yan‐Lan Long, Sai‐Feng Zhao, Zhen Zhao, Wan‐Ting Xie, Zi‐Ming Li, Hao‐Ming Lu, Tian‐Xiao Gao, Zhen‐Zhen Fang, Ti Zhou, Bo‐Xing Li, Xia Yang, Guo‐Quan Gao, Wei‐Wei Qi   +15 more
wiley   +1 more source

Graph-Theoretic Limits of Distributed Computation: Entropy, Eigenvalues, and Chromatic Numbers. [PDF]

Entropy (Basel)
Deylam Salehi MR, Malak D.
europepmc   +1 more source

Electron‐Beam Excited Conductive Atomic Force Microscopy for Back Contact Free, Wafer‐Scale and In‐Line Compatible Electrical Characterization of 2D Materials

Advanced Science, EarlyView.
Electron‐beam excited conductive atomic force microscopy is demonstrated. Here, a low‐energy e‐beam impinging on the sample surface can be used to perform C‐AFM in a new configuration that enables comparable results to classic C‐AFM sensitivity, while unlocking applications previously not possible in terms of large‐area analysis and wafer‐scale ...
Md Ashiqur Rahman Laskar, Sakib Ahmed, Pinakapani Tummala, Alessandro Molle, Alessio Lamperti, Renee Sailus, Youssry Y Botros, Milan Pesic, Rob Davenport, Ondřej Novotný, Jan Neuman, Fabrizio Toia, Ivan Sanchez Esqueda, Seth Ariel Tongay, Umberto Celano   +14 more
wiley   +1 more source

A Rare Cause of Neonatal Seizures-A Case Report. [PDF]

J Paediatr Child Health
Brennan E, Wildes D, Cleary B, Williams P, Colleran G, Boyle MA.   +5 more
europepmc   +1 more source

Preservation of ALYREF Phase Separation Mitigates Doxorubicin‐Induced Cardiomyocyte DNA Damage and Cardiotoxicity

Advanced Science, EarlyView.
Binding of Doxorubicin to ALYREF disrupts its phase‐separated condensate and induces DNA damage and apoptosis in cardiomyocytes Abstract The clinical utility of the anticancer agent doxorubicin (DOX) is limited by its dose‐dependent cardiotoxicity.
Xinlu Gao, Yifu Shen, Zhihui Xiao, Zhenbo Han, Xu Liu, Ao Cai, Yanan Tian, Guang Lian, Wenya Ma, Yining Liu, Rui Gong, Hanjing Li, Xiuxiu Wang, Zhongyu Ren, Naufal Zagidullin, Lei Yu, Ye Tian, Yu Liu, Zhenwei Pan, Baofeng Yang, Benzhi Cai   +20 more
wiley   +1 more source

Choice of Processing Pipelines for T1-Weighted Brain MRI Impacts Association and Prediction Analyses. [PDF]

Hum Brain Mapp
Delzant E, Colliot O, Couvy-Duchesne B.
europepmc   +1 more source

Development of a 3D Human Colon Model Along with Bioelectronics for the Induction and Monitoring of Diseases

Advanced Science, EarlyView.
We present a functional three‐dimensional in‐vivo‐mimicking human colon (3D‐IVM‐HC) model engineered via Freeform Reversible Embedding of Suspended Hydrogels bioprinting with gelatin methacrylate (GelMA)/alginate hydrogels. This 3D non‐animal model replicates crypt‐like architectures, epithelial polarization, and stromal–tumor interactions, showing ...
Jorge Alfonso Tavares‐Negrete, Sahar Najafikoshnoo, Anita Ghandehari, Mozhgan Keshavarz, Quinton Smith, Armand Ahmetaj, Steven Zanganeh, Rahim Esfandyarpour   +7 more
wiley   +1 more source