Results 211 to 220 of about 45,382 (265)

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Independent set-based multivariate graph polynomials for fractal-type silicate triangle structures. [PDF]

Front Chem
Nithiya KS, Easwaramoorthy D.
europepmc   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Recognizing distance-count matrices. [PDF]

PLoS One
Boldi P, Prezioso C, Furia F, Stewart I.
europepmc   +1 more source

Long-term effectiveness and safety of cystic fibrosis transmembrane conductance regulator modulators and their impact on the lives of people with cystic fibrosis. [PDF]

Am J Respir Crit Care Med
Stahl M, Mall MA, Ramsey B, Ramos KJ.
europepmc   +1 more source

Groups acting on trees with Tits' independence property (P): With an appendix by Stephan Tornier. [PDF]

Math Ann
Reid CD, Smith SM.
europepmc   +1 more source

Design and Analysis of Minimum-Weighted Connected Capacitated Vertex Cover Algorithms for Link Monitoring in IoT-Enabled WSNs. [PDF]

Sensors (Basel)
Kol M, Uslu EE, Dagdeviren ZA, Dagdeviren O.   +3 more
europepmc   +1 more source

Efficient Hamiltonian, structure and trace distance learning of Gaussian states. [PDF]

Nat Commun
Fanizza M, Rouzé C, Stilck França D.
europepmc   +1 more source

Counting Spinal Phylogenetic Networks. [PDF]

Bull Math Biol
Francis A, Hendriksen M.
europepmc   +1 more source