Results 101 to 110 of about 5,978,611 (274)

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken   +8 more
wiley   +1 more source

Experiments on Nonlocal Fluid‐Flow Metamaterials

open access: yesAdvanced Science, EarlyView.
A nonlocal fluid‐flow metamaterial composed of standard microfluidic tubes and connectors is designed. Hence, the current of the system at one position depends on the gradient of fluid flow at many other positions, leading to unusual alternating backward and forward laminar flows of water.
Ke Wang, Yi Chen, Martin Wegener
wiley   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao   +8 more
wiley   +1 more source

The Adjacency Matrix of One Type of Directed Graph and the Jacobsthal Numbers and Their Determinantal Representation

open access: yesJournal of Applied Mathematics, 2012
Recently there is huge interest in graph theory and intensive study on computing integer powers of matrices. In this paper, we consider one type of directed graph. Then we obtain a general form of the adjacency matrices of the graph.
Fatih Yılmaz, Durmuş Bozkurt
doaj   +1 more source

A fast practical algorithm for the vertex separation of unicyclic graphs [PDF]

open access: yes, 2008
The vertex separation of a graph is the minimum vertex separation of a linear layout of that graph over all its linear layouts. A linear layout of a graph is an arrangement of its vertices in a line and the vertex separation of a linear layout is maximum
Markov, Minko Marinov.
core  

Independent sets of maximum weight in apple-free graphs [PDF]

open access: yes, 2010
We present the first polynomial-time algorithm to solve the maximum weight independent set problem for apple-free graphs, which is a common generalization of several important classes where the problem can be solved efficiently, such as claw-free graphs,
Lozin, Vadim V.   +2 more
core   +1 more source

Synergistic Mechano‐Fluidic Self‐Fusion of Poly(Vinyl Alcohol)‐Modified Liquid‐Metal Particles for Post‐Treatment‐Free Soft Electronics

open access: yesAdvanced Science, EarlyView.
Poly(vinyl alcohol)‐modified liquid‐metal particles form conductive networks through spray‐induced self‐fusion without additional post‐treatment. Spray impact initiates oxide‐shell rupture and electrical contact, while subsequent Marangoni flow and capillary forces promote particle redistribution, neck growth, and network consolidation. This sequential
Keun‐Young Yook   +13 more
wiley   +1 more source

The t-Pebbling Number of Jahangir Graph [PDF]

open access: yes, 2012
Given a configuration of pebbles on the vertices of a connected graph G, a pebbling move (or pebbling step) is defined as the removal of two pebbles from a vertex and placing one pebble on an adjacent vertex.
Samuel Jeyaseelan, S.   +2 more
core   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

open access: yesAdvanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee   +5 more
wiley   +1 more source

work. The method of modeling and the contents of our articles [SL1], [SL2], [RIS1], [PB3], and [PB4] will be explained below. 2. The Method of Modeling

open access: yes, 2008
In this research, graph theory is applied for two purposes. One is to express the routing of communication and the other is to express the condition of roads.
Graph Theory
core  

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