Results 41 to 50 of about 558,175 (268)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Vertical Distribution, Community and Population Structures of the Planktonic Chaetognatha in the Western Subarctic Pacific: Insights on the Eukrohnia Species Group

Oceans, 2023
In the oceans, Chaetognatha can contribute significantly to the total zooplankton biomass (up to 10–30%). The genus Eukrohnia, the dominant Chaetognath genus in the western subarctic Pacific, includes E. hamata and E. bathypelagica.
Yuya Nakamura, Haochen Zhang, Atsushi Yamaguchi   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Depth-Dependent Spatiotemporal Dynamics of Overwintering Pelagic Microcystis in a Temperate Water Body

Microorganisms, 2021
Cyanobacteria in the genus Microcystis are dominant components of many harmful algal blooms worldwide. Their pelagic–benthic life cycle helps them survive periods of adverse conditions and contributes greatly to their ecological success.
Haolun Tian, Junjie Jin, Bojian Chen, Daniel D. Lefebvre, Stephen C. Lougheed, Yuxiang Wang   +5 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Vertical distribution characteristics analysis of shallow stratum geothermal temperature field in the Southeastern Hancheng Fault, Guanzhong Basin

Youqicang pingjia yu kaifa, 2022
Inorder to further study the vertical distribution characteristics of the shallow geothermal temperature field in the southeastern of Hancheng, Guanzhong Basin.
XUE Yuze, ZHANG Yugui, HAN Yuanhong, ZHANG Tinghui, XUE Chao, XIAO Juhui, PENG Zhenzhou, GUO Bin   +7 more
doaj  

Resilience of the Copepod Oithona similis to Climatic Variability: Egg Production, Mortality, and Vertical Habitat Partitioning

Frontiers in Marine Science, 2020
There has been an overall decline in copepod populations across the North Atlantic over the past few decades. Reasons for these declines are unclear, and several major species, including the cyclopoid copepod Oithona similis, have maintained stable ...
Louise Elisabeth Cornwell, Elaine S. Fileman, John T. Bruun, John T. Bruun, Andrew Garwood Hirst, Andrew Garwood Hirst, Glen Adam Tarran, Helen S. Findlay, Ceri Lewis, Timothy James Smyth, A. J. McEvoy, A. Atkinson   +11 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source