Results 121 to 130 of about 945,119 (285)

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Vertical agreements and competition restraints

, 2011
Samkeppnisreglur eru mikilvægar á frjálsum markaði þar sem vörur og þjónusta ganga kaupum og sölum. Við gerð hvers kyns viðskiptasamninga er almennt um að ræða tvenns konar samninga: annars vegar lóðrétta og hins vegar lárétta.
Egill Gylfason 1985-
core   +1 more source

The economic theory of quasi-exclusive territory [PDF]

This paper introduces the economic theory of gquasi-exclusive territory.h We consider vertical dealings with two upstream firms and four downstream firms that compete in two separate markets.
Daisuke Nikae, Takeshi Ikeda
core  

Solvent‐Desorption‐Induced Formation of a Long‐Period Polymorph Yielding a High‐Performance Porphyrin‐Based Organic Semiconductor

Advanced Science, EarlyView.
Solvent‐desorption‐induced structural transformation of 5,15‐bisphenyl‐tetrabenzoporphyrin generates a long‐period polymorph, in which the π‐stacking direction rotates by 90° between adjacent layers within the crystal while largely retaining crystallographic integrity.
Kazuya Miyazaki, Keitaro Yamamoto, Mitsuaki Yamauchi, Yoshiyuki Mizuhata, Hiroshi Matsuda, Nobutaka Shioya, Takeshi Hasegawa, Hiroko Yamada   +7 more
wiley   +1 more source

Vine‐Inspired Soft Robotics: Materials, Actuations, and Emerging Applications

Advanced Science, EarlyView.
Vine‐inspired robots grow from the tip, enabling navigation through confined spaces with minimal disturbance. This Review summarizes material and actuation strategies for vine‐inspired growth, key functions including steering, retraction, attachment, branching, and variable stiffness, and emerging applications spanning medical intervention, confined ...
Jiahao Wu, Xingyun Liu, Fangzhou Wang, Huili Ren, Chaojun Zhang, Ziyu Ren, Zunqi Liu, Jing Li   +7 more
wiley   +1 more source

One‐Step Access to Ultra‐Bright Macrocyclic Oligo‐BODIPYs Featuring Long‐Lived Cyclic Excitons

Angewandte Chemie, EarlyView.
Strong Fluorescence Meets Long Lifetimes: A template‐free, one‐step synthesis affords a series of methylene‐bridged macrocyclic oligo‐BODIPYs combining strong fluorescence with exceptionally long fluorescence lifetimes. Steady‐state and time‐resolved optical spectroscopy reveal unique excitonic coupling conditions and unusual size‐dependent ...
Lukas J. Patalag, Atanu Patra, Mike Pauls, Roland Wilcken, Yuriy Kononevich, Nils van Staalduinen, Peter G. Jones, Andreas Steffen, Thorben Cordes, Christoph Bannwarth, Daniel B. Werz   +10 more
wiley   +2 more sources

Vertical Restraints and Horizontal Control

This paper considers vertical restraints in a multi-market retail setting in which each retailer sells the complete line of manufactured goods. Vertical restraints by one manufacturer on the retailers of its product serve as an instrument to exert ...
Hamilton, Stephen F., Innes, Robert
core  

Sector-based explanation of vertical integration in distribution systems; Evidence from France [PDF]

Based on recent data concerning the French distribution networks in retail and services, this paper highlights several stylized facts relating to the sector-based differences in the organizational choices. Until now this issue has not been studied in the
Muriel Fadairo, Magali Chaudey, Gwennaël Solard   +2 more
core  

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Luminescence Vapochromism of a Cu(I)/Na Phosphane Iodide Assembly Based on a Secondary‐Sphere Sodium Response

Angewandte Chemie, EarlyView.
The luminescence of a heterometallic d‐s {Cu2I2Na2} phosphane‐phosphinate aggregate is regulated by an interplay of Na+–π/I– contacts and reversible coordination of oxygen‐containing organic molecules to Na ions. Structural variations caused by the incoming guest lead to a wide and selective variation of the emission color and illustrate a new approach
Henna Korhonen, Dorota Głosz, Mariia Beliaeva, Andrey Belyaev, Constance Lecourt, Adrien Schlachter, Karine Costuas, Guillaume Calvez, Robert Podgajny, Christophe Lescop, Igor O. Koshevoy   +10 more
wiley   +2 more sources