Results 51 to 60 of about 499,903 (264)

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Climatic Type Characteristics of the Winter Yunnan-Guizhou Quasi-Stationary Front

Gaoyuan qixiang
Based on the topographic characteristics of the Yunnan-Guizhou Plateau, the objective standard index of the intensity of the Yunnan-Guizhou quasi-stationary front in winter is defined by using the FNL atmospheric reanalysis data of 24 years (2000-2023 ...
REN Manlin, BAI Hui, YAN Xiaodong, XIA Yang, LI Zhongyan, ZHENG Bei   +5 more
doaj   +1 more source

Relationships between Temperature at Surface Level and in the Troposphere over the Northern Hemisphere

Atmosphere, 2023
The thermal structure of the troposphere remains a hot topic, including modelling issues as well as temperature field simulations. This study evaluates the relationship between the air temperature at the Earth’s surface and the temperature of various ...
Zbigniew Ustrnul, Jadwiga Woyciechowska, Agnieszka Wypych   +2 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

The Vertical Structure of a Loop Current Eddy [PDF]

Journal of Geophysical Research: Oceans, 2018
AbstractThe vertical structure of a recently detached Loop Current Eddy (LCE) is studied using in situ data collected with an underwater glider from August to November 2016. Altimetry and Argo data are analyzed to discuss the context of the eddy shedding and evolution as well as the origin and transformation of its thermohaline properties.
T. Meunier, E. Pallás‐Sanz, M. Tenreiro, E. Portela, J. Ochoa, A. Ruiz‐Angulo, S. Cusí   +6 more
openaire   +2 more sources

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Seasonal states and carbon dynamics in key areas of the carbon polygon in the Chechen Republic, Russia

Юг России: экология, развитие
The aim of the work was to analyze the relationship between carbon dynamics and changes in the states of natural territorial complexes in two key areas of the carbon polygon in the Chechen Republic from the standpoint of landscape and landscape ...
A. N. Gunya, U. T. Gayrabekov, L. Sh. Makhmudova, Z. Sh. Gagaeva   +3 more
doaj   +1 more source

The Effects of Trade Liberalisation in a Vertical Structure [PDF]

SSRN Electronic Journal, 2010
AbstractDespite the importance of international trade on intermediate goods, the literature did not pay much attention to this aspect in determining the effects of trade liberalization in the presence of a labor union. We take up this issue here and show the effects of trade liberalization on the final goods and/or the intermediate goods, where the ...
Yao Liu, Arijit Mukherjee
openaire   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source