Results 1 to 10 of about 1,100,883 (182)

MR parkinsonism index predicts vertical supranuclear gaze palsy in patients with PSP–parkinsonism [PDF]

Neurology, 2016
To identify a biomarker for predicting the appearance of vertical supranuclear gaze palsy (VSGP) in patients affected by progressive supranuclear palsy-parkinsonism (PSP-P).Twenty-four patients with PSP-P were enrolled in the current study. Patients were clinically followed up every 6 months until the appearance of VSGP or the end of the follow-up (4 ...
Maria Salsone, Salvatore Nigro, Giuseppe Nicoletti   +2 more
exaly   +7 more sources

Global Rather Than Vertical-Selective Saccadic Abnormalities in Progressive Supranuclear Palsy. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Nguyen DD, Paine M, Lee S, Fazlollahi A, Wang BB, O'Sullivan JD, Nestor PJ.   +6 more
europepmc   +2 more sources

Progressive Supranuclear Palsy (PSP): An Orthoptic Assessment [PDF]

British and Irish Orthoptic Journal
Aim: Progressive supranuclear palsy (PSP) is an atypical Parkinsonian disorder which, like other atypical Parkinsonian disorders, displays neurological motor and oculomotor signs at different stages along the disease course.
Dominic Burdon, Stephen Mullin, Christopher Harris   +2 more
doaj   +2 more sources

Progressive Cognitive Decline and Pyramidal Signs in a Patient With a Novel Homozygous c.395A>T; p.Lys132Met Mutation in CHCHD2 [PDF]

Clin Case Rep
ABSTRACT Biallelic CHCHD2 variants are rare. We report a consanguineous man with a novel homozygous CHCHD2 c.395A>T (p.Lys132Met) variant who developed progressive cognitive decline, apraxia, oculomotor impairment, and pyramidal signs without parkinsonism.
Salari M, Soltani A, Etemadifar M, Rezaei K.   +3 more
europepmc   +2 more sources

Progressive Supranuclear Palsy in India: Insights from a Large Multicenter Clinical Cohort (Project PAIR-PSP). [PDF]

Mov Disord Clin Pract
Background Progressive supranuclear palsy (PSP) is a rare and devastating tauopathy with limited global data. Given India's large population, genetic diversity, and clinical heterogeneity, large multicenter datasets are crucial to enrich global understanding of PSP. Objective To characterize the demographic, clinical, and phenotypic profiles of a large
Kukkle PL, Garg D, Ganguly J, Desai S, Kandadai RM, Mehta S, Wadia PM, Joshi D, Sahoo L, Paramanandam V, Reddy TAV, Mukherjee A, Krishnan S, Shetty K, Sankhla C, Agarwal P, Shah HS, Bhowmick S, Chandarana M, Venkata M, Geetha TS, Menon R, Charugulla S, Murugan S, Gupta R, Kumar N, Biswas A, Kumar H, Borgohain R, Morris H, Ramprasad VL, Parkinson's Research Alliance of India (PRAI) and the Global Parkinson's Genetic Program (GP2).   +31 more
europepmc   +2 more sources

Assessment of Mitochondrial DNA Copy Number in Progressive Supranuclear Palsy Patients: Evidence From a Pilot Study. [PDF]

Eur J Neurol
ABSTRACT Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative tauopathy characterized by early postural instability and vertical gaze palsy. Mitochondrial dysfunctions have been increasingly implicated in the pathogenesis of neurodegenerative disorders, including PSP.
Citrigno L, Cerantonio A, Gagliardi M, Procopio R, Felicetti A, Aureli A, Morelli M, Annesi G.   +7 more
europepmc   +2 more sources

Unveiling the Distinctive Brain Functional Dynamics Between Parkinson's Disease and Progressive Supranuclear Palsy. [PDF]

CNS Neurosci Ther
Using hidden Markov models (HMM) to analyze dynamic brain states from resting‐state fMRI, this study identifies opposing temporal dynamics in Parkinson's disease (PD) and progressive supranuclear palsy (PSP). PD patients show reduced fractional occupancy in unimodal networks, while PSP patients exhibit increased occupancy and prolonged duration in ...
Ye C, Shi J, Fang J, Wu T, Chan P, Ma J, Ma T.   +6 more
europepmc   +2 more sources

Cognitive, Motor and Oculomotor Contributions to the Trail Making Test in Progressive Supranuclear Palsy. [PDF]

Mov Disord Clin Pract
Abstract Background Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by motor, oculomotor and cognitive impairments. Yet disentangling cognitive deficits from motor and oculomotor dysfunction remains a diagnostic and methodological challenge.
Garcia-Cordero I, Hadian M, Vargas-Gonzalez JC, Monteiro M, Gold D, Khoja A, Morales-Rivero A, Couto B, Tang-Wai D, Fox S, Kovacs GG, Lang AE, Tartaglia MC.   +12 more
europepmc   +2 more sources

Asymmetric Upper Limb Dysfunction Demonstrated at the Bedside: A Phenomenology Video. [PDF]

Mov Disord Clin Pract
Movement Disorders Clinical Practice, Volume 13, Issue 9, Page 2286-2287, September 2026.
Lueg G, Fruth M, Neuendorff NR, Wirth R, Hobert MA.   +4 more
europepmc   +2 more sources

Clinical and molecular spectrum of Niemann-Pick disease type C patients in India [PDF]

Frontiers in Pediatrics
BackgroundNiemann–Pick disease type C (NPC) is a rare autosomal recessive lysosomal disorder caused by pathogenic variants in NPC1 or NPC2, resulting in impaired intracellular cholesterol trafficking and progressive neurovisceral disease.
Jayesh Sheth, Aadhira Nair, Riddhi Bhavsar, Pankti Jasani, Niyati Saini, Aditi Baluni, Vykuntaraju K. Gowda, Mamta Muranjan, Ashish Bavdekar, Abhijeet Botre, Sandeep Kadam, Sheela Nampoothiri, Anupkumar P. Rawool, Chaitanya A. Datar, Nishant Dharsandia, Shruti Bajaj, Anupriya Kaur, Seema Kapoor, Dhaval Solanki, Siddharth M. Shah, Mahesh Kamate, I. C. Verma, Sushma K. Suresh, Vrajesh Udani, Rutuja Badge, Prachi Karnik, Soumya Mercy, Frenny Sheth, Harsh Sheth   +28 more
doaj   +2 more sources