Results 71 to 80 of about 130,057 (295)

TeV gamma-ray emission from accreting binary pulsars [PDF]

, 1990
The high-mass X-ray binary SMC X-1 has been observed during the interval 1986-1989 at a threshold γ-ray energy of 0.4 TeV using the University of Durham Mark III air Cerenkov telescope at Narrabri.
Mannings, Vincent, Mannings, V
core  

VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint

Scientific Reports
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied across several radiation modalities, including photons, protons and clinical energy electrons ...
Hannah C. Wanstall, Pierre Korysko, Wilfred Farabolini, Roberto Corsini, Joseph J. Bateman, Vilde Rieker, Abigail Hemming, Nicholas T. Henthorn, Michael J. Merchant, Elham Santina, Amy L. Chadwick, Cameron Robertson, Alexander Malyzhenkov, Roger M. Jones   +13 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Diffuse galactic sub-MeV γ-ray excess from high-energy electrons [PDF]

, 2005
Recent INTEGRAL observations have confirmed the existence of diffuse sub-MeV radiation from the inner Galaxy. We propose a new explanation for the origin of this diffuse component in terms of electrostatic bremsstrahlung radiation from high-energy ...
R. Schröder, A. W. Strong, Schröder, R., Strong, A., Schlickeiser, R., Strong, A. W., R. Schlickeiser   +6 more
core   +1 more source

Low-Energy Electron Inelastic Mean Free Path of Graphene Measured by a Time-of-Flight Spectrometer

Nanomaterials, 2021
The detailed examination of electron scattering in solids is of crucial importance for the theory of solid-state physics, as well as for the development and diagnostics of novel materials, particularly those for micro- and nanoelectronics.
Ivo Konvalina, Benjamin Daniel, Martin Zouhar, Aleš Paták, Ilona Müllerová, Luděk Frank, Jakub Piňos, Lukáš Průcha, Tomáš Radlička, Wolfgang S. M. Werner, Eliška Materna Mikmeková   +10 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

XMM-Newton observations of HESS J1813-178 reveal a composite Supernova remnant [PDF]

, 2007
We present X-ray and 12CO(J=1-0) observations of the very-high-energy (VHE) γ-ray source HESS J1813-178 with the aim of understanding the origin of the γ-ray emission.
Funk, S., Astrophysics, Vink, J., Sub High energy Astrophysics begr 1/1/15   +3 more
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Substorm related changes in precipitation in the dayside auroral zone-a multi instrument case study [PDF]

, 2002
International audienceA period (08:10?14:40 MLT, 11 February 1997) of enhanced electron density in the D- and E-regions is investigated using EISCAT, IRIS and other complementary instruments.
J. Manninen (7637285), E. Donovan (7591466), I. W. McCrea, Honary, F., Manninen, J., P. C. Anderson, A. J. Kavanagh (7614089), F. Honary (7604621), E. Donovan, I. W. McCrea (7594871), Kavanagh, A. J., A. J. Kavanagh, P. C. Anderson (7637288), McCrea, I. W., F. Honary, J. Manninen, E. E. Woodfield (7590071), E. E. Woodfield, Donovan, E., Woodfield, E. E., Anderson, P. C.   +20 more
core   +1 more source