Results 1 to 10 of about 480 (154)

First in Vitro Measurement of VHEE Relative Biological Effectiveness (RBE) in Lung and Prostate Cancer Cells Using the ARES Linac at DESY [PDF]

Scientific Reports
Very high energy electrons (VHEE) are a potential candidate for radiotherapy applications. This includes tumours in inhomogeneous regions such as lung and prostate cancers, due to the insensitivity of VHEE to inhomogeneities.
Thomas Vinatier, Florian Burkart
exaly   +5 more sources

VHEE FLASH Sparing Effect Measured at CLEAR, CERN With DNA Damage of pBR322 Plasmid as a Biological Endpoint [PDF]

Scientific Reports
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied across several radiation modalities, including photons, protons and clinical energy electrons ...
Hannah C. Wanstall, Pierre Korysko, Wilfred Farabolini, Roberto Corsini, Joseph J. Bateman, Vilde Rieker, Abigail Hemming, Nicholas T. Henthorn, Michael J. Merchant, Elham Santina, Amy L. Chadwick, Cameron Robertson, Alexander Malyzhenkov, Roger M. Jones   +13 more
exaly   +5 more sources

A compact C-band FLASH electron linear accelerator prototype for the VHEE SAFEST project [PDF]

Frontiers in Oncology
FLASH therapy, a novel cancer treatment technique, aims to control tumor growth, sparing the healthy tissue from radiation damage and thus increasing the therapeutic ratio.
Lucia Giuliano, Lucia Giuliano, David Alesini, Fabio Cardelli, Martina Carillo, Enrica Chiadroni, Enrica Chiadroni, Massimiliano Coppola, Giacomo Cuttone, Alessandro Curcio, Alessandro Curcio, Angelica De Gregorio, Angelica De Gregorio, Roberto Di Raddo, Luigi Faillace, Stefano Farina, Stefano Farina, Luca Ficcadenti, Daniele Francescone, Gaia Franciosini, Giovanni Franzini, Alessandro Gallo, Marco Magi, Marco Magi, Giorgio S. Mauro, Andrea Mostacci, Andrea Mostacci, Luigi Palumbo, Luigi Palumbo, Vincenzo Patera, Vincenzo Patera, Francesca Perondi, Massimo Petrarca, Stefano Pioli, Romolo Remetti, Alessio Sarti, Alessio Sarti, Angelo Schiavi, Bruno Spataro, Giuseppe Torrisi, Alessandro Vannozzi, Mauro Migliorati, Mauro Migliorati   +42 more
doaj   +5 more sources

Comparison of protons and very high-energy electrons transmission pencil-beam-scanning for FLASH radiotherapy [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Very High-Energy Electron (VHEE) radiotherapy stands as a promising alternative to proton therapy in view of the FLASH effect, which allows for differential sparing of healthy tissues under ultra-high dose rate irradiation.
Flavia Gesualdi, Louis Ermeneux, Pierre Lansonneur, Mateusz Sitarz, Pierre Loap, Gilles Créhange, Anthony Magliari, Ludovic De Marzi   +7 more
doaj   +2 more sources

Treatment planning for very high energy electrons: Studies that indicate the potential of the modality [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Radiotherapy using Very High Energy Electrons (VHEE) has the potential to reduce dose to organs at risk compared to photons.
James L. Bedford, Uwe Oelfke
doaj   +2 more sources

Start-to-end modelling of laser-plasma acceleration, beam transport and dose deposition of very high-energy electrons for radiotherapy [PDF]

Scientific Reports
The proposed radiotherapy using very high-energy electron (VHEE) beams generated by a laser-plasma accelerator has garnered significant interest due to its dose distribution capabilities and potential to address limitations of traditional photon-based ...
Rajakrishna Kalvala, Anton Golovanov, Arnaud Courvoisier, Tomer Friling, Eyal Kroupp, Lidan Grishko, Victor Malka   +6 more
doaj   +2 more sources

Optimizing focused very-high-energy electron beams for radiation therapy based on Monte Carlo simulation [PDF]

Scientific Reports
A TOPAS-based optimization program has been developed to precisely concentrate the dose of focused very-high-energy electron (VHEE) beams on deep-seated targets.
Chaofan An, Wei Zhang, Zeyi Dai, Jia Li, Xiong Yang, Jike Wang, Yuancun Nie   +6 more
doaj   +2 more sources

FLASH effect tissue sparing comparison for X-ray, hadron, and VHEE irradiation modalities [PDF]

Scientific Reports
FLASH-RT is an irradiation modality using Ultra-High-Dose-Rates, where a healthy tissue sparing effect is observed. Different particle types have distinct characteristics in lateral and distal dose deposition, which can affect the amount of healthy ...
Atia Ibrahimi, Stefan Both, Marc-Jan van Goethem, Francesco Romano, Alexander Gerbershagen   +4 more
doaj   +2 more sources

Treatment planning comparison of focused very high energy electron and volumetric modulated arc therapy [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Very high energy electron (VHEE) radiotherapy gained interest owing to technical advances and its potential for FLASH radiotherapy.
Florian Amstutz, Chengchen Zhu, Werner Volken, Hannes A. Loebner, Silvan Mueller, Sascha Frei, Jenny Bertholet, Peter Manser, Michael K. Fix   +8 more
doaj   +2 more sources

Preclinical tumor control with a laser-accelerated high-energy electron radiotherapy prototype [PDF]

Nature Communications
Radiotherapy using very-high-energy electron (VHEE) beams (50-300 MeV) has attracted considerable attention due to its advantageous dose deposition characteristics, enabling deep penetration and easy manipulation by magnetic components.
Zhiyuan Guo, Shuang Liu, Bing Zhou, Junqi Liu, Haiyang Wang, Yifei Pi, Xiaoyan Wang, Yingyi Mo, Bo Guo, Jianfei Hua, Yang Wan, Wei Lu   +11 more
doaj   +2 more sources