Results 1 to 10 of about 381 (150)

Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications [PDF]

Scientific Reports, 2021
This paper presents the first demonstration of deeply penetrating dose delivery using focused very high energy electron (VHEE) beams using quadrupole magnets in Monte Carlo simulations.
Ranald I Mackay, J K Jones
exaly   +9 more sources

VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint [PDF]

Scientific Reports
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied across several radiation modalities, including photons, protons and clinical energy electrons ...
Roger M Jones
exaly   +9 more sources

First in vitro measurement of VHEE relative biological effectiveness (RBE) in lung and prostate cancer cells using the ARES linac at DESY [PDF]

Scientific Reports
Very high energy electrons (VHEE) are a potential candidate for radiotherapy applications. This includes tumours in inhomogeneous regions such as lung and prostate cancers, due to the insensitivity of VHEE to inhomogeneities.
Roger M Jones, Kopke Michael
exaly   +7 more sources

CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications [PDF]

Scientific Reports
Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due to their highly penetrating nature and their applicability as a modality for FLASH (ultra-high dose-rate) radiotherapy. The dose distributions due to VHEE
Ranald I Mackay
exaly   +8 more sources

Comparison of secondary radiation dose between pencil beam scanning and scattered delivery for proton and VHEE radiotherapy [PDF]

Medical Physics
Abstract Background Very high‐energy electrons (VHEEs) in radiotherapy may offer several potential advantages over conventional electron beams and other techniques, for example, the fact that they can be used at ultra‐high dose rates (UHDRs), therefore enabling FLASH radiotherapy.
A Patriarca, Regis Ferrand, Gilles Créhange   +2 more
exaly   +3 more sources

A compact C-band FLASH electron linear accelerator prototype for the VHEE SAFEST project [PDF]

Frontiers in Oncology
FLASH therapy, a novel cancer treatment technique, aims to control tumor growth, sparing the healthy tissue from radiation damage and thus increasing the therapeutic ratio.
Lucia Giuliano, Lucia Giuliano, David Alesini, Fabio Cardelli, Martina Carillo, Enrica Chiadroni, Enrica Chiadroni, Massimiliano Coppola, Giacomo Cuttone, Alessandro Curcio, Alessandro Curcio, Angelica De Gregorio, Angelica De Gregorio, Roberto Di Raddo, Luigi Faillace, Stefano Farina, Stefano Farina, Luca Ficcadenti, Daniele Francescone, Gaia Franciosini, Giovanni Franzini, Alessandro Gallo, Marco Magi, Marco Magi, Giorgio S. Mauro, Andrea Mostacci, Andrea Mostacci, Luigi Palumbo, Luigi Palumbo, Vincenzo Patera, Vincenzo Patera, Francesca Perondi, Massimo Petrarca, Stefano Pioli, Romolo Remetti, Alessio Sarti, Alessio Sarti, Angelo Schiavi, Bruno Spataro, Giuseppe Torrisi, Alessandro Vannozzi, Mauro Migliorati, Mauro Migliorati   +42 more
doaj   +5 more sources

Potential of the CLARA test facility for VHEE radiotherapy research

Frontiers in Physics
The Compact Linear Accelerator for Research and Applications (CLARA) is a test facility at the STFC Daresbury Laboratory, which is capable of delivering ultra-bright electron bunches of up to 250 MeV beam energy.
Deepa Angal-Kalinin, Deepa Angal-Kalinin, Deepa Angal-Kalinin, Stewart Boogert, Stewart Boogert, James Kevin Jones, James Kevin Jones   +6 more
exaly   +5 more sources

Design of a 100-MeV compact VHEE beam line in Tsinghua University

Frontiers in Physics
A 100-MeV Compact Electron Accelerator design has been proposed for Very High Energy Electron (VHEE) radiotherapy research at Tsinghua University. The microwave source for this system is a 50 MW X-band klystron, paired with a pulse compressor featuring a
Hao Zha, Xiancai Lin, Focheng Liu
exaly   +4 more sources

Focused beam dosimetry of short VHEE bunches [PDF]

Relativistic Plasma Waves and Particle Beams as Coherent and Incoherent Radiation Sources IV, 2021
Accelerators driven by 10s TW-class lasers can produce electron bunches with femtosecond-scale duration and energy of 100s of MeV. A potential application of such short bunches is high-dose rate radiotherapy, which could transition to FLASH radiotherapy if a sufficiently large dose is delivered in a single shot.
Enrico Brunetti, Antoine Maitrallain, D A Jaroszynski   +2 more
exaly   +4 more sources

Comparison of protons and very high-energy electrons transmission pencil-beam-scanning for FLASH radiotherapy [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Very High-Energy Electron (VHEE) radiotherapy stands as a promising alternative to proton therapy in view of the FLASH effect, which allows for differential sparing of healthy tissues under ultra-high dose rate irradiation.
Flavia Gesualdi, Louis Ermeneux, Pierre Lansonneur, Mateusz Sitarz, Pierre Loap, Gilles Créhange, Anthony Magliari, Ludovic De Marzi   +7 more
doaj   +2 more sources