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Exploring the Metabolic Impact of FLASH Radiotherapy [PDF]
CancersFLASH radiotherapy (FLASH RT) is an innovative modality in cancer treatment that delivers ultrahigh dose rates (UHDRs), distinguishing it from conventional radiotherapy (CRT). FLASH RT has demonstrated the potential to enhance the therapeutic window by reducing radiation-induced damage to normal tissues while maintaining tumor control, a phenomenon ...
Febe Geirnaert +2 more
exaly +8 more sources
FLASH Radiotherapy: History and Future [PDF]
Frontiers in Oncology, 2021 The biological effects of radiation dose to organs at risk surrounding tumor target volumes are a major dose-limiting constraint in radiotherapy. This can mean that the tumor cannot be completely destroyed, and the efficacy of radiotherapy will be ...
Binwei Lin +7 more
doaj +5 more sources
Flash Radiotherapy: Innovative Cancer Treatment
Encyclopedia, 2023 Flash radiotherapy (Flash-RT) is an innovative technique used in radiotherapy for cancer treatment because it delivers an extremely high dose of radiation (>40 Gy/s) to the tumour in a very short period of time, typically within a fraction of a second ...
James C. L. Chow, Harry E. Ruda
doaj +5 more sources
Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?
Frontiers in Oncology, 2020 Radiotherapy is a cornerstone of both curative and palliative cancer care. However, radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be reduced, a greater dose of radiation could be given therefore facilitating ...
Joseph D. Wilson +4 more
doaj +6 more sources
Translational Research in FLASH Radiotherapy—From Radiobiological Mechanisms to In Vivo Results
Biomedicines, 2021 FLASH radiotherapy, or the administration of ultra-high dose rate radiotherapy, is a new radiation delivery method that aims to widen the therapeutic window in radiotherapy.
Loredana G. Marcu +3 more
doaj +4 more sources
The evolution of FLASH radiotherapy: a bibliometric analysis [PDF]
Frontiers in OncologyIntroductionFLASH radiotherapy (FLASH-RT) represents a groundbreaking technique, characterized by its ultra-high dose rate and its remarkable ability to spare normal tissues from damage. Numerous studies on FLASH-RT have been conducted worldwide. However,
Shuokai Jia +12 more
doaj +4 more sources
FLASH Radiotherapy: Mechanisms of Biological Effects and the Therapeutic Potential in Cancer [PDF]
BiomoleculesRadiotherapy is an important treatment for many unresectable advanced malignant tumors, and radiotherapy-associated inflammatory reactions to radiation and other toxic side effects are significant reasons which reduce the quality of life and survival of ...
Ouying Yan +3 more
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FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy [PDF]
BMC MedicineBackground Conventional radiotherapy (CONV-RT) is widely used for cancer treatment, but its efficacy is limited by toxicity to surrounding healthy tissues.
Giulia Furini +25 more
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Reinventing Radiobiology in the Light of FLASH Radiotherapy [PDF]
Annual Review of Cancer Biology, 2023 Ultrahigh–dose rate FLASH radiotherapy (FLASH-RT) is a potentially paradigm-shifting treatment modality that holds the promise of expanding the therapeutic index for nearly any cancer. At the heart of this exciting technology comes the capability to ameliorate major normal tissue complications without compromising the efficacy of tumor killing.
Charles L Limoli +1 more
exaly +5 more sources
Research progresses on FLASH radiotherapy and its application for the treatment of digestive system tumors [PDF]
Discover OncologyOver the past decades, advances in technique have turned radiotherapy into a precise and effective modality for cancer treatment. Nevertheless, the biological effect on organs surrounding the tumor target area is a main dose-limiting element in ...
Siqian Zhang +2 more
doaj +2 more sources