FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy [PDF]
BMC MedicineBackground Conventional radiotherapy (CONV-RT) is widely used for cancer treatment, but its efficacy is limited by toxicity to surrounding healthy tissues.
Giulia Furini +25 more
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FLASH radiotherapy as an emerging paradigm in radioimmunotherapy: biological rationale, preclinical evidence, and translational roadmap [PDF]
Frontiers in ImmunologyUltra-high dose rate radiotherapy (FLASH-RT) has emerged as a promising technology in recent years. Unlike conventional radiotherapy (CONV-RT), FLASH-RT delivers radiation at an ultra-high dose rate over a very short duration.
Dongliang Li +8 more
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Research progresses on FLASH radiotherapy and its application for the treatment of digestive system tumors [PDF]
Discover OncologyOver the past decades, advances in technique have turned radiotherapy into a precise and effective modality for cancer treatment. Nevertheless, the biological effect on organs surrounding the tumor target area is a main dose-limiting element in ...
Siqian Zhang +2 more
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Phenomenological insights into the FLASH radiotherapy-induced abscopal effect [PDF]
Frontiers in OncologyBackgroundThe abscopal effect suggests that the impact of radiotherapy extends beyond the direct tumor local regression, due to activation of the immune response. Its effectiveness may vary depending on whether high- or low-radiation doses are used.
Paolo Castorina +5 more
doaj +2 more sources
The Biophysics of Flash Radiotherapy: Tools for Measuring Tumor and Normal Tissues Microenvironment [PDF]
AntioxidantsUltra-high dose rate radiotherapy known as Flash radiotherapy (FLASH-RT) offers tremendous opportunities to improve the therapeutic ratio of radiotherapy by sparing the normal tissue while maintaining similar tumoricidal efficacy. However, the underlying
Islam G. Ali, Issam El Naqa
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Harnessing Particle Ions for FLASH Radiotherapy [PDF]
CellsFLASH radiotherapy continues to be an emerging clinical treatment that utilises ultra-high dose rate radiation (>40 Gy/s) to elicit normal tissue sparing compared to conventional (CONV) dose rate delivery.
Alex J. Bembridge +2 more
doaj +2 more sources
Potential effect of FLASH radiotherapy on testicular damage: a review of current evidence [PDF]
Frontiers in OncologyRadiotherapy is a major source of ionizing radiation that adversely affects the male reproductive system. FLASH radiotherapy (FLASH-RT), a novel technique delivering ultra-high dose rate (UHDR) radiation, has shown promise in reducing normal tissue ...
Xiaoyu Zhi +10 more
doaj +2 more sources
FLASH radiotherapy preserves hepatic function and maintains metabolic homeostasis in a murine breast cancer model: an experimental preclinical study [PDF]
Radiation OncologyBackground Radiotherapy (RT) for treating breast cancer can result in incidental dose deposition to the liver, leading to functional impairment. FLASH radiotherapy (FLASH-RT), delivered at ultra-high dose rates (UHDR), has demonstrated remarkable normal ...
Xingyu Lu +4 more
doaj +2 more sources
Preliminary mechanistic study of mitochondrial function in intestinal protection mediated by high-energy X-ray FLASH radiotherapy [PDF]
Radiation OncologyPurpose Ultra-high dose rate (UHDR) radiation retains tumor-killing efficacy while mitigating toxicity to normal tissues, holding a promising transformative radiotherapy paradigm.
Xiaofei Hao +10 more
doaj +2 more sources
The evolution of FLASH radiotherapy: a bibliometric analysis [PDF]
Frontiers in OncologyIntroductionFLASH radiotherapy (FLASH-RT) represents a groundbreaking technique, characterized by its ultra-high dose rate and its remarkable ability to spare normal tissues from damage. Numerous studies on FLASH-RT have been conducted worldwide. However,
Shuokai Jia +12 more
doaj +2 more sources