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Mechanisms of FLASH effect [PDF]
Frontiers in Oncology, 2022 FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high dose rate (≥ 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects: first, compared with conventional dose rate radiotherapy, FLASH-RT can ...
Binwei Lin, Tangzhi Dai, Lin Binwei
exaly +6 more sources
Influence factor and mechanism of FLASH effect [PDF]
Frontiers in OncologyFLASH radiotherapy (FLASH-RT) represents an innovative treatment modality utilizing ultra-high dose-rate irradiation (>40 Gy/s). The FLASH effect, induced by FLASH-RT, is characterized by the selective radioprotective effect of normal tissue while ...
Tingyu Feng +4 more
doaj +7 more sources
<i>In vitro</i> assays for investigating the FLASH effect. [PDF]
Expert Rev Mol Med, 2022 AbstractFLASH radiotherapy is a novel technique that has been shown in numerous preclinicalin vivostudies to have the potential to be the next important improvement in cancer treatment. However, the biological mechanisms responsible for the selective FLASH sparing effect of normal tissues are not yet known.
Adrian G +4 more
europepmc +8 more sources
The FLASH effect depends on oxygen concentration. [PDF]
Br J Radiol, 2020 Objective: Recent in vivo results have shown prominent tissue sparing effect of radiotherapy with ultra-high dose rates (FLASH) compared to conventional dose rates (CONV). Oxygen depletion has been proposed as the underlying mechanism, but in vitro data to support this have been lacking. The aim of the current study
Adrian G +5 more
europepmc +6 more sources
The influence of beam parameters on FLASH effect [PDF]
Frontiers in OncologyUltra-high dose rate radiotherapy (FLASH-RT) is typically defined as an external beam radiotherapy that utilizes a dose rate of 40 Gy/s or higher, compared with conventional dose rate radiotherapy (≤0.1 Gy/s).
Binwei Lin +15 more
doaj +5 more sources
Cancer Cells Can Exhibit a Sparing FLASH Effect at Low Doses Under Normoxic In Vitro-Conditions [PDF]
Frontiers in Oncology, 2021 BackgroundIrradiation with ultra-high dose rate (FLASH) has been shown to spare normal tissue without hampering tumor control in several in vivo studies. Few cell lines have been investigated in vitro, and previous results are inconsistent. Assuming that
Gabriel Adrian +12 more
doaj +2 more sources
The FLASH effect—an evaluation of preclinical studies of ultra-high dose rate radiotherapy [PDF]
Frontiers in OncologyFLASH radiotherapy (FLASH-RT) is a novel radiotherapy approach based on the use of ultra-high dose radiation to treat malignant cells. Although tumours can be reduced or eradicated using radiotherapy, toxicities induced by radiation can compromise ...
Josie May McGarrigle +4 more
doaj +2 more sources
Mechanisms of the FLASH effect: current insights and advances [PDF]
Frontiers in Cell and Developmental BiologyRadiotherapy is a fundamental tool in cancer treatment, utilized in over 60% of cancer patients during their treatment course. While conventional radiotherapy is effective, it has limitations, including prolonged treatment durations, which extend patient
Giulia Rosini +6 more
doaj +2 more sources
Increased spread of global flash droughts threatens vegetation productivity resilience [PDF]
Nature CommunicationsFlash drought (faster-developing drought) has been pervasively intensified, posing detrimental constraints on vegetation productivity. However, the potential expansion of flash droughts from flash drought hotspots to non-hotspots and its associated risks
Renjie Guo +9 more
doaj +2 more sources
Six-month evaluation of normal mouse brain side effects: Comparing FLASH and conventional proton partial brain irradiation [PDF]
Clinical and Translational Radiation OncologyBackground and purpose: Preclinical studies demonstrated ultra-high dose-rate radiation treatment ability to effectively control local tumour growth while reducing damage to healthy tissues.
Manuel Bernabei +10 more
doaj +2 more sources