Results 41 to 50 of about 194,970 (290)

Factors Influencing the Biological Effects of FLASH Irradiation

open access: yesAntioxidants
Among the methods for increasing the specificity of tumor radiotherapy, FLASH radiotherapy (FLASH-RT) stands out, having recently entered clinical trials.
Sergey Igorevich Glukhov   +2 more
doaj   +1 more source

Architecture, flexibility and performance of a special electron linac dedicated to Flash radiotherapy research: electronFlash with a triode gun of the centro pisano flash radiotherapy (CPFR)

open access: yesFrontiers in Physics, 2023
The FLASH effect is a radiobiological phenomenon that has garnered considerable interest in the clinical field. Pre-clinical experimental studies have highlighted its potential to reduce side effects on healthy tissues while maintaining isoeffectiveness ...
F. Di Martino   +31 more
doaj   +1 more source

Effect of a Lightning Flash [PDF]

open access: yesNature, 1902
DURING the storm on Wednesday, September 10, a house opposite my rooms in Fulham was struck by lightning at 4.40 p.m. Curiously enough, at the moment of the occurrence I was looking at the exact spot, and it may be of interest to record what occurred.
openaire   +1 more source

Stimulus dependence of the flash-lag effect

open access: yesVision Research, 2007
When two moving objects are presented in perfect alignment, but are not visible for the same amount of time, the briefer object will often be perceived as "lagging" the object of greater duration. Most investigations of this flash-lag effect (FLE) employ high velocity broadband stimuli, such as lines or dots with sharp boundaries and flashes with rapid
Cantor, Christopher R.L.   +1 more
openaire   +2 more sources

REMOTE - Mechanisms of the FLASH effect [PDF]

open access: yes, 2022
A re-emergence of research implementing radiation delivery at ultra-high dose rates (UHDR) has triggered intense interest in the radiation sciences and has opened a new field of investigation in radiobiology.
Vozenin, Marie-Catherine
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

FLASH radiotherapy combined with immunotherapy: From biological mechanisms to blockbuster therapeutics

open access: yesTranslational Oncology
FLASH ultra-high dose rate radiotherapy (RT) can effectively exert the protective effect on normal tissue and reduce the risk of treatment-related toxicity, without compromising the killing effect on tumor tissue, resulting in a significant differential ...
Yu Wang, Shu-Nan Qi, Nan Bi, Ye-Xiong Li
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Knowledge of, and response to, upland flash flooding: a case study of flood risk management of the 2005 flash flood in upper Ryedale, North Yorkshire, U.K. [PDF]

open access: yes, 2012
The dangerous hazard posed by flash flooding to upland communities is likely to increase due to climate change. The flood risk management policy approach has become predominant since the 1990s, with an emphasis on the public awareness of, and responses ...
HOPKINS, JONATHAN
core  

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