Results 1 to 10 of about 188 (70)

Mechanisms of FLASH effect

Frontiers in Oncology, 2022
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high dose rate (≥ 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects: first, compared with conventional dose rate radiotherapy, FLASH-RT can ...
Binwei Lin, Binwei Lin, Dan Huang, Feng Gao, Yiwei Yang, Dai Wu, Yu Zhang, Gang Feng, Tangzhi Dai, Xiaobo Du   +9 more
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Comparison of intratumor and local immune response between MV X-ray FLASH and conventional radiotherapies

Clinical and Translational Radiation Oncology, 2023
Background/Purpose: Investigating the antitumor effect and intratumor as well as local immune response in breast cancer-bearing mice after MV X-ray ultra-high dose rate radiotherapy (FLASH-RT) and conventional dose rate radiotherapy (CONV-RT).
Hongyu Zhu, Dehuan Xie, Ying Wang, Runda Huang, Xi Chen, Yiwei Yang, Bin Wang, Yinglin Peng, Jianxin Wang, Dexin Xiao, Dai Wu, Chao-Nan Qian, Xiaowu Deng   +12 more
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FLASH Radiotherapy: History and Future

Frontiers in Oncology, 2021
The biological effects of radiation dose to organs at risk surrounding tumor target volumes are a major dose-limiting constraint in radiotherapy. This can mean that the tumor cannot be completely destroyed, and the efficacy of radiotherapy will be ...
Binwei Lin, Feng Gao, Yiwei Yang, Dai Wu, Yu Zhang, Gang Feng, Tangzhi Dai, Xiaobo Du   +7 more
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Simulation study of a novel small animal FLASH irradiator (SAFI) with integrated inverse-geometry CT based on circularly distributed kV X-ray sources

Scientific Reports, 2023
Ultra-high dose rate (UHDR) radiotherapy (RT) or FLASH-RT can potentially reduce normal tissue toxicity. A small animal irradiator that can deliver FLASH-RT treatments similar to clinical RT treatments is needed for pre-clinical studies of FLASH-RT.
Yuewen Tan, Shuang Zhou, Jonathan Haefner, Qinghao Chen, Thomas R. Mazur, Arash Darafsheh, Tiezhi Zhang   +6 more
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Radiobiological Aspects of FLASH Radiotherapy

Biomolecules, 2022
Radiotherapy (RT) is one of the primary treatment modalities for cancer patients. The clinical use of RT requires a balance to be struck between tumor effect and the risk of toxicity.
Eline Hageman, Pei-Pei Che, Max Dahele, Ben J. Slotman, Peter Sminia   +4 more
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Comparable Long-Term Tumor Control for Hypofractionated FLASH Versus Conventional Radiation Therapy in an Immunocompetent Rat Glioma Model

Advances in Radiation Oncology, 2022
Purpose: To ensure a clinical translation of FLASH radiation therapy (FLASH-RT) for a specific tumor type, studies on tumor control and toxicity within the same biological system are needed.
Elise Konradsson, MSc, Emma Liljedahl, MD, Emma Gustafsson, MSc, Gabriel Adrian, MD, PhD, Sarah Beyer, MSc, Suhayb Ehsaan Ilaahi, MSc, Kristoffer Petersson, PhD, Crister Ceberg, PhD, Henrietta Nittby Redebrandt, MD, PhD   +8 more
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Flash Radiotherapy: Innovative Cancer Treatment

Encyclopedia, 2023
Flash radiotherapy (Flash-RT) is an innovative technique used in radiotherapy for cancer treatment because it delivers an extremely high dose of radiation (>40 Gy/s) to the tumour in a very short period of time, typically within a fraction of a second ...
James C. L. Chow, Harry E. Ruda
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The Impacts of FLASH Radiation Therapy and Conventional Radiation Therapy on the Cognitive Abilities of Mice

Advances in Radiation Oncology
Purpose: Preclinical studies have demonstrated that FLASH radiation therapy (RT) delivered at ultrahigh-dose rates exerts a preferential normal tissue-sparing effect.
Renke He, MD, Shengqiang Xie, MD, Lehui Du, MD, Wenxuan Li, MM, Jianxin Wang, PhD, Xianhong Liu, PhD, Dai Wu, PhD, Yiwei Yang, PhD, Baolin Qu, MD, Gang Cheng, MD, Jianning Zhang, MD   +10 more
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Long-term anti-tumor effects following both conventional radiotherapy and FLASH in fully immunocompetent animals with glioblastoma

Scientific Reports, 2022
Radiotherapy can induce an immunological response. One limiting factor is side effects on normal tissue. Using FLASH radiotherapy, side effects could possibly be reduced.
Emma Liljedahl, Elise Konradsson, Emma Gustafsson, Karolina Förnvik Jonsson, Jill K. Olofsson, Crister Ceberg, Henrietta Nittby Redebrandt   +6 more
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Key changes in the future clinical application of ultra-high dose rate radiotherapy

Frontiers in Oncology, 2023
Ultra-high dose rate radiotherapy (FLASH-RT) is an external beam radiotherapy strategy that uses an extremely high dose rate (≥40 Gy/s). Compared with conventional dose rate radiotherapy (≤0.1 Gy/s), the main advantage of FLASH-RT is that it can reduce ...
Binwei Lin, Mi Fan, Tingting Niu, Yuwen Liang, Haonan Xu, Wenqiang Tang, Xiaobo Du   +6 more
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