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Efficacy of Radiotherapy FLASH-RT: From Treating Lung Cancer to Preventing Pulmonary Fibrosis [PDF]

Dose-Response
FLASH radiotherapy (FLASH-RT) is a radiotherapy technique that achieves ultra-high dose rates in a fraction of a second. Based on data from experimental animal models, FLASH-RT appears to protect a number of normal tissues from radiation-induced damage ...
Tianyu Yang, Zhiming Xu, Wentao Hu, Zhifei Cao, Yongsheng Zhang   +4 more
doaj   +6 more sources

The Therapeutic Potential of FLASH-RT for Pancreatic Cancer. [PDF]

Cancers (Basel), 2022
Recent preclinical evidence has shown that ionizing radiation given at an ultra-high dose rate (UHDR), also known as FLASH radiation therapy (FLASH-RT), can selectively reduce radiation injury to normal tissue while remaining isoeffective to conventional radiation therapy (CONV-RT) with respect to tumor killing.
Okoro CM, Schüler E, Taniguchi CM.
europepmc   +5 more sources

Hypofractionated FLASH-RT as an Effective Treatment against Glioblastoma that Reduces Neurocognitive Side Effects in Mice. [PDF]

Clin Cancer Res, 2021
Abstract Purpose: Recent data have shown that single-fraction irradiation delivered to the whole brain in less than tenths of a second using FLASH radiotherapy (FLASH-RT), does not elicit neurocognitive deficits in mice. This observation has important clinical implications for the management of
Montay-Gruel P, Acharya MM, Gonçalves Jorge P, Petit B, Petridis IG, Fuchs P, Leavitt R, Petersson K, Gondré M, Ollivier J, Moeckli R, Bochud F, Bailat C, Bourhis J, Germond JF, Limoli CL, Vozenin MC.   +16 more
europepmc   +9 more sources

FLASH-RT does not affect chromosome translocations and junction structures beyond that of CONV-RT dose-rates. [PDF]

Radiother Oncol, 2023
Abstract The molecular and cellular mechanisms driving the enhanced therapeutic ratio of ultra-high dose-rate radiotherapy (FLASH-RT) over slower conventional (CONV-RT) radiotherapy dose-rate remain to be elucidated. However, attenuated DNA damage and transient oxygen depletion are among several proposed models. Here,
Barghouth PG, Melemenidis S, Montay-Gruel P, Ollivier J, Viswanathan V, Jorge PG, Soto LA, Lau BC, Sadeghi C, Edlabadkar A, Zhang R, Ru N, Baulch JE, Manjappa R, Wang J, Le Bouteiller M, Surucu M, Yu A, Bush K, Skinner L, Maxim PG, Loo BW, Limoli CL, Vozenin MC, Frock RL.   +24 more
europepmc   +9 more sources

The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation. [PDF]

Radiother Oncol, 2023
Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 Gy (30 Gy total) conventional radiotherapy.
Limoli CL, Kramár EA, Almeida A, Petit B, Grilj V, Baulch JE, Ballesteros-Zebadua P, Loo BW, Wood MA, Vozenin MC.   +9 more
europepmc   +6 more sources

The importance of hypoxia in radiotherapy for the immune response, metastatic potential and FLASH-RT. [PDF]

Int J Radiat Biol, 2022
Hypoxia (low oxygen) is a common feature of solid tumors that has been intensely studied for more than six decades. Here we review the importance of hypoxia to radiotherapy with a particular focus on the contribution of hypoxia to immune responses, metastatic potential and FLASH radiotherapy, active areas of research by leading women in the field ...
Moon EJ, Petersson K, Olcina MM.
europepmc   +4 more sources

Individual pulse monitoring and dose control system for pre-clinical implementation of FLASH-RT. [PDF]

Phys Med Biol, 2022
Abstract Objective. Existing ultra-high dose rate (UHDR) electron sources lack dose rate independent dosimeters and a calibrated dose control system for accurate delivery. In this study, we aim to develop a custom single-pulse dose monitoring and a real-time dose-based control system for a FLASH enabled clinical linear
Ashraf MR, Rahman M, Cao X, Duval K, Williams BB, Jack Hoopes P, Gladstone DJ, Pogue BW, Zhang R, Bruza P.   +9 more
europepmc   +4 more sources

Dose rate and dose robustness for proton transmission FLASH-RT treatment in lung cancer. [PDF]

Front Oncol, 2022
PurposesTo evaluate the plan quality and robustness of both dose and dose rate of proton pencil beam scanning (PBS) transmission FLASH delivery in lung cancer treatment.Methods and materialsAn in-house FLASH planning platform was used to optimize 10 lung cancer patients previously consecutively treated with proton stereotactic body radiation therapy ...
Wei S, Lin H, Huang S, Shi C, Xiong W, Zhai H, Hu L, Yu G, Press RH, Hasan S, Chhabra AM, Choi JI, Simone CB, Kang M.   +13 more
europepmc   +4 more sources

Mechanisms of FLASH effect

Frontiers in Oncology, 2022
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high dose rate (≥ 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects: first, compared with conventional dose rate radiotherapy, FLASH-RT can ...
Binwei Lin, Tangzhi Dai, Lin Binwei
exaly   +3 more sources

Investigating the oxygen dependence of FLASH-RT using electron paramagnetic resonance imaging. [PDF]

Radiother Oncol
The FLASH effect occurs when radiation given at ultra-high dose rates spares healthy tissue while achieving isoeffective tumor control relative to conventional (CONV) dose rate irradiation. Limited data has implicated oxygen in the FLASH effect. This study investigated the effect of tissue oxygen tension (pO2) on gastrointestinal (GI) FLASH sparing in ...
Waldrop T, Murley G, Velasquez B, Konradsson E, Neill D, Connell L, Hernandez AL, Delahoussaye A, Schuler FW, La Cerda J, Li Z, Pagel MD, Schüler E.   +12 more
europepmc   +4 more sources