Results 31 to 40 of about 698,242 (242)

One‐year follow‐up after fractionated ultra‐high‐dose‐rate FLASH radiotherapy in patient with extramammary Paget disease of the scrotum

Precision Radiation Oncology
Objective Ultrahigh‐dose‐rate radiotherapy (FLASH‐RT) has been shown to reduce radiation‐induced normal tissue injury in preclinical studies. Here, we describe the first patient worldwide to receive fractionated FLASH‐RT.
Hui Luo, Chengliang Yang, Ronghu Mao, Leijie Ma, Hongchang Lei, Peng Chen, Yanping Zhang, Meng Xu, Chao Wang, Yiwu Wang, Mingxia Wu, Chanjun Sun, Han Liu, Hui Liu, Hong Ge   +14 more
doaj   +1 more source

An insight into hypothesized biological mechanisms contributing to the Flash effect

Frontiers in Physics, 2023
In recent years, FLASH radiotherapy (FLASH RT) has gained attention in preclinical studies as a potential advancement in cancer treatment. The great advantage of FLASH RT is the ultra-fast, high doses delivery that have a similar or greater effect on ...
Francesca Del Debbio, Maria Sofia Bertilacchi, Alessandra Gonnelli, Alessandra Gonnelli, Eleonora Da Pozzo, Eleonora Da Pozzo, Eleonora Da Pozzo, Valentina Tozzini, Valentina Tozzini, Claudia Martini, Claudia Martini, Claudia Martini, Simone Capaccioli, Simone Capaccioli, Simone Capaccioli, Barbara Costa, Barbara Costa   +16 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Revisiting Stability Criteria in Ball‐Milled High‐Entropy Alloys: Do Hume–Rothery and Thermodynamic Rules Equally Apply?

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez, Alejandro F. Manchón‐Gordón, Antonio Vidal‐Crespo, Rafael Caballero‐Flores, Jhon J. Ipus, Clara F. Conde   +5 more
wiley   +1 more source

FLASH radiotherapy: Research process from basic experimentation to clinical application

Precision Radiation Oncology, 2021
FLASH radiotherapy (FLASH‐RT) has gained attention as an ultra‐high dose rate RT in recent years. This treatment significantly shortens the time of RT and reduces the influence of tumor movement caused by breathing or other factors.
Xiaohui Wang, Hui Luo, Xiaoli Zheng, Hong Ge   +3 more
doaj   +1 more source

Flash radioterapija kot nova možnost v radioterapevtski tehnologiji

, 2022
Purpose: The purpose of this article is to present FLASH radiotherapy (FLASH-RT) as a new radiation therapy method, to explain its mechanisms of action, to present possible sources and devices of radiation and to identify its advantages and disadvantages
Žager Marciuš, Valerija, Kuralt, Matej
core   +1 more source

Entropy‐Driven Design of Low‐Melting‐Point Alloys via Compositionally Complex Strategy

Advanced Engineering Materials, EarlyView.
Conventional low‐melting‐point alloys (LMPAs) are limited by a narrow compositional space and inherent property trade‐offs. This review presents an entropy‐driven design strategy that overcomes these limitations, ushering in a new class of low‐melting‐point compositionally complex alloys (LMCCAs).
Yinghui Shang, Jianxiang Zhao, Zhaoqi Chen, Hao Gong, Yinsen Yan, Junlei Tao, Yong Yang   +6 more
wiley   +1 more source

Evaluation of single-fraction high dose FLASH radiotherapy in a cohort of canine oral cancer patients

Frontiers in Oncology, 2023
BackgroundFLASH radiotherapy (RT) is a novel method for delivering ionizing radiation, which has been shown in preclinical studies to have a normal tissue sparing effect and to maintain anticancer efficacy as compared to conventional RT.
Betina Børresen, Maja L. Arendt, Elise Konradsson, Kristine Bastholm Jensen, Sven ÅJ. Bäck, Per Munck af Rosenschöld, Crister Ceberg, Kristoffer Petersson, Kristoffer Petersson   +8 more
doaj   +1 more source

Achieving High ON State Current through Ferroelectric Polarization‐Dependent Interfacial Resistance Switching in Undoped Orthorhombic HfO2 Films

Advanced Functional Materials, EarlyView.
Ferroelectric tunnel junction devices based on epitaxial undoped ferroelectric HfO2 films demonstrate stable switching endurance of over 106 switching cycles, low write voltages of ±3 V, 16 measured resistance states, and neuromorphic capability.
Markus Hellenbrand, Nuno Estrócio, Ji S. Kim, Babak Bakhit, Marian C. Istrate, Corneliu Ghica, Tiago Rebelo, Nives Strkalj, Abin Varghese, Bernardo Almeida, Luís S. Marques, Bipin Rajendran, Judith L. MacManus‐Driscoll, José P. B. Silva   +13 more
wiley   +1 more source

Exploring the mechanisms of protective effect of high-energy X-ray FLASH radiotherapy on intestine through multi omics analysis

Radiation Oncology
Background The aim of this study is to investigate the potential mechanisms underlying the protective effects of high-energy X-ray FLASH radiotherapy (FLASH-RT) on intestine through multi-omics analysis.
Huan Du, Binwei Lin, Yihan Zhu, Xiaofei Hao, Mingming Tang, Wei Wu, Decai Wang, Yiwei Yang, Yuwen Liang, Wenqiang Tang, Haonan Xu, Jie Li, Feng Gao, Xiaobo Du   +13 more
doaj   +1 more source