Results 11 to 20 of about 698,242 (242)

Efficacy of Radiotherapy FLASH-RT: From Treating Lung Cancer to Preventing Pulmonary Fibrosis [PDF]

Dose-Response
FLASH radiotherapy (FLASH-RT) is a radiotherapy technique that achieves ultra-high dose rates in a fraction of a second. Based on data from experimental animal models, FLASH-RT appears to protect a number of normal tissues from radiation-induced damage ...
Tianyu Yang, Zhiming Xu, Wentao Hu, Zhifei Cao, Yongsheng Zhang   +4 more
doaj   +3 more sources

Hypofractionated FLASH-RT as an Effective Treatment against Glioblastoma that Reduces Neurocognitive Side Effects in Mice [PDF]

Clin Cancer Res, 2021
Recent data have shown that single-fraction irradiation delivered to the whole brain in less than tenths of a second using FLASH radiotherapy (FLASH-RT), does not elicit neurocognitive deficits in mice.
Moeckli, R., Acharya, M.M., Gondré, M., Vozenin, M.C., Bailat, C., Leavitt, R., Gonçalves Jorge, P., Bochud, F., Petridis, I.G., Germond, J.F., Montay-Gruel, P., Fuchs, P., Bourhis, J., Petit, B., Ollivier, J., Limoli, C.L., Petersson, K., Jorge, Patrik Gonçalves, Petersson, Kristoffer, Bochud, François, Germond, Jean-François, Bailat, Claude, Petridis, Ioannis G, Vozenin, Marie-Catherine, Bourhis, Jean, Petit, Benoît, Montay-Gruel, Pierre, Limoli, Charles L, Acharya, Munjal M, Gondré, Maude, Leavitt, Ron, Ollivier, Jonathan, Moeckli, Raphael, Fuchs, Philippe   +33 more
core   +3 more sources

The Therapeutic Potential of FLASH-RT for Pancreatic Cancer [PDF]

Cancers (Basel), 2022
Recent preclinical evidence has shown that ionizing radiation given at an ultra-high dose rate (UHDR), also known as FLASH radiation therapy (FLASH-RT), can selectively reduce radiation injury to normal tissue while remaining isoeffective to conventional
Emil Schüler, Cullen M. Taniguchi, Chidi M. Okoro   +2 more
core   +2 more sources

FLASH radiotherapy as an emerging paradigm in radioimmunotherapy: biological rationale, preclinical evidence, and translational roadmap [PDF]

Frontiers in Immunology
Ultra-high dose rate radiotherapy (FLASH-RT) has emerged as a promising technology in recent years. Unlike conventional radiotherapy (CONV-RT), FLASH-RT delivers radiation at an ultra-high dose rate over a very short duration.
Dongliang Li, Xiaofeng Wang, Shun Lu, Lintao Li, Yue Su, Xianliang Wang, Yongjie Li, Jinyi Lang, Jie Zhou   +8 more
doaj   +3 more sources

FLASH-RT does not affect chromosome translocations and junction structures beyond that of CONV-RT dose-rates [PDF]

Radiother Oncol, 2023
BACKGROUND AND PURPOSE: The impact of radiotherapy (RT) at ultra high vs conventional dose rate (FLASH vs CONV) on the generation and repair of DNA double strand breaks (DSBs) is an important question that remains to be investigated.
Baulch, Janet, Edlabadkar, A., Limoli, Charles, Barghouth, P.G., Ru, N., Baulch, J.E., Surucu, Murat, Melemenidis, Stavros, Wang, J., Loo, Billy, Viswanathan, Vignesh, Maxim, P.G., Lau, Brianna, Brianna C. Lau, Jinghui Wang, Patrik G. Jorge, Edlabadkar, Anushka, Sadeghi, C., Vozenin, Marie-Catherine, Vozenin, M.C., Montay-Gruel, Pierre, Jorge, Patrik, Maxim, Peter, Vignesh Viswanathan, Amy Yu, Manjappa, Rakesh, Montay-Gruel, P., Ollivier, Jonathan, Anushka Edlabadkar, Sadeghi, Cheyenne, Murat Surucu, Frock, Richard, Marie Le Bouteiller, Lau, B.C., Ollivier, J., Richard Zhang, Ru, Ning, Luis A. Soto, Loo, B.W., Ning Ru, Paul G. Barghouth, Jonathan Ollivier, Billy W. Loo Jr., Skinner, Lawrie, Melemenidis, S., Rakesh Manjappa, Barghouth, Paul, Soto, L.A., Bush, Karl, Yu, Amy, Viswanathan, V., Peter G. Maxim, Le Bouteiller, Marie, Yu, A., Zhang, Richard, Janet E. Baulch, Charles L. Limoli, Wang, Jinghui, Zhang, R., Surucu, M., Richard L. Frock, Soto, Luis, Karl Bush, Frock, R.L., Bush, K., Lawrie Skinner, Le Bouteiller, M., Stavros Melemenidis, Manjappa, R., Pierre Montay-Gruel, Marie-Catherine Vozenin, Skinner, L., Cheyenne Sadeghi, Jorge, P.G., Limoli, C.L.   +74 more
core   +2 more sources

Comparable survival in rats with intracranial glioblastoma irradiated with single-fraction conventional radiotherapy or FLASH radiotherapy [PDF]

Frontiers in Oncology, 2023
BackgroundRadiotherapy increases survival in patients with glioblastoma. However, the prescribed dose is limited by unwanted side effects on normal tissue.
Emma Liljedahl, Elise Konradsson, Karin Linderfalk, Emma Gustafsson, Kristoffer Petersson, Kristoffer Petersson, Crister Ceberg, Henrietta Nittby Redebrandt, Henrietta Nittby Redebrandt   +8 more
doaj   +4 more sources

Influence factor and mechanism of FLASH effect [PDF]

Frontiers in Oncology
FLASH radiotherapy (FLASH-RT) represents an innovative treatment modality utilizing ultra-high dose-rate irradiation (>40 Gy/s). The FLASH effect, induced by FLASH-RT, is characterized by the selective radioprotective effect of normal tissue while ...
Tingyu Feng, Tingyu Feng, Tianyang He, Wentao Ye, Lisha Xiang   +4 more
doaj   +2 more sources

X‑ray FLASH RT inhibits lung cancer bone metastasis via activating CD4⁺ T-cell‑mediated antitumor immunity with modulation of Th17 cell response [PDF]

OncoImmunology
Lung cancer is characterized by rapid progression and poor prognosis, with 50%–70% of patients presenting local or distant metastasis at diagnosis, among which bone metastasis is the most common type.
Yao Huang, Tao Wu, Wen Yang, Yuan-yuan Liang, Yun-fei Sun, Chao-fan Ma, Ruo Tang, Rui-ci Liang, Xue-ting Zheng, Hui-wen Luo, Cheng-he Ding, Xiao-an Li, Yan Zhou   +12 more
doaj   +2 more sources

Consensus statement on the exploration of clinical translation and application of electron ultra‐high dose rate FLASH radiotherapy

Precision Radiation Oncology
Ultra‐high dose rate FLASH Radiotherapy (FLASH‐RT) has attracted wide attention because the well‐known FLASH effect and the extremely short irradiation time.
Hui Luo, Chengliang Yang, Jinbo Yue, Hong Ge   +3 more
doaj   +2 more sources

FLASH radiotherapy preserves hepatic function and maintains metabolic homeostasis in a murine breast cancer model: an experimental preclinical study [PDF]

Radiation Oncology
Background Radiotherapy (RT) for treating breast cancer can result in incidental dose deposition to the liver, leading to functional impairment. FLASH radiotherapy (FLASH-RT), delivered at ultra-high dose rates (UHDR), has demonstrated remarkable normal ...
Xingyu Lu, Dehuan Xie, Liang Cui, Hang Shang, Linghong Zhou   +4 more
doaj   +2 more sources