Results 11 to 20 of about 517,787 (283)

FLASH-RT

Radiološki vjesnik
FLASH radiotherapy (FLASH-RT) is an emerging technique that delivers radiation at ultra-high dose rates, offering the potential to achieve equal or superior tumour control compared to conventional radiotherapy, while significantly reducing toxicity to surrounding healthy tissues.
Sara Morović, Damir Ciprić
core   +3 more sources

Is singlet oxygen involved in FLASH-RT? [PDF]

J Appl Clin Med Phys, 2023
Alanazi A, Jay-Gerin JP, Blázquez-Castro A.   +2 more
europepmc   +3 more sources

FLASH-RT for pulmonary protection: a comprehensive review of mechanisms, technological advances, and clinical translation. [PDF]

Front Oncol
FLASH radiotherapy (FLASH-RT), characterized by ultra-high dose rates (>40 Gy/s), has demonstrated remarkable normal tissue-sparing effects in preclinical models while maintaining tumor control. This review specifically focuses on FLASH-mediated pulmonary protection, a critical concern in thoracic oncology.
Wen Y, Liu X, Zhang X, Long L, Feng J, Zhang Z.   +5 more
europepmc   +3 more sources

The Impacts of FLASH Radiation Therapy and Conventional Radiation Therapy on the Cognitive Abilities of Mice [PDF]

Advances in Radiation Oncology
Purpose: Preclinical studies have demonstrated that FLASH radiation therapy (RT) delivered at ultrahigh-dose rates exerts a preferential normal tissue-sparing effect.
Renke He, MD, Shengqiang Xie, MD, Lehui Du, MD, Wenxuan Li, MM, Jianxin Wang, PhD, Xianhong Liu, PhD, Dai Wu, PhD, Yiwei Yang, PhD, Baolin Qu, MD, Gang Cheng, MD, Jianning Zhang, MD   +10 more
doaj   +2 more sources

Preliminary mechanistic study of mitochondrial function in intestinal protection mediated by high-energy X-ray FLASH radiotherapy [PDF]

Radiation Oncology
Purpose Ultra-high dose rate (UHDR) radiation retains tumor-killing efficacy while mitigating toxicity to normal tissues, holding a promising transformative radiotherapy paradigm.
Xiaofei Hao, Huan Du, Binwei Lin, Decai Wang, Wei Wu, Mingming Tang, Huayan Zhang, Yihan Zhu, Yu Zhang, Yiwei Yang, Xiaobo Du   +10 more
doaj   +2 more sources

FLASH radiotherapy and immunotherapy synergy: mechanisms, strategies, and clinical translation prospects [PDF]

Frontiers in Immunology
FLASH radiotherapy (FLASH-RT), characterized by ultra-high dose rate irradiation (≥40 Gy/s), has generated substantial interest in radiation oncology due to its reported capacity to preserve normal tissues while maintaining tumor control—a phenomenon ...
Qianyi Liu, Xianhu Zeng, Yongze He, Linsen Zhou, Ying Tang, Shuotong Liu, Xiaobin Wang, Shiyan Shen, Jialin Ji, Zhen Liu, Jiangping Li   +10 more
doaj   +2 more sources

FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy [PDF]

BMC Medicine
Background Conventional radiotherapy (CONV-RT) is widely used for cancer treatment, but its efficacy is limited by toxicity to surrounding healthy tissues.
Giulia Furini, Eduarda Mota da Silva, Alice Usai, Gaia Scabia, Claudia Kusmic, Francesco Faita, Andrea Cavalieri, Mariagrazia Celentano, Mario Costa, Filippo Rossi, Giulia Asero, Roberta Di Pietro, Emanuela Guerra, Stefano Lattanzio, Tonia Luca, Sergio Castorina, Roberto Cusano, Riccardo Berutti, Jessica Milia, Simone Capaccioli, Alessandra Gonnelli, Noemi Giannini, Fabiola Paiar, Saverio Cinti, Fabio Di Martino, Margherita Maffei   +25 more
doaj   +2 more sources

One‐year follow‐up after fractionated ultra‐high‐dose‐rate FLASH radiotherapy in patient with extramammary Paget disease of the scrotum [PDF]

Precision Radiation Oncology
Objective Ultrahigh‐dose‐rate radiotherapy (FLASH‐RT) has been shown to reduce radiation‐induced normal tissue injury in preclinical studies. Here, we describe the first patient worldwide to receive fractionated FLASH‐RT.
Hui Luo, Chengliang Yang, Ronghu Mao, Leijie Ma, Hongchang Lei, Peng Chen, Yanping Zhang, Meng Xu, Chao Wang, Yiwu Wang, Mingxia Wu, Chanjun Sun, Han Liu, Hui Liu, Hong Ge   +14 more
doaj   +2 more sources

Exploring the mechanisms of protective effect of high-energy X-ray FLASH radiotherapy on intestine through multi omics analysis [PDF]

Radiation Oncology
Background The aim of this study is to investigate the potential mechanisms underlying the protective effects of high-energy X-ray FLASH radiotherapy (FLASH-RT) on intestine through multi-omics analysis.
Huan Du, Binwei Lin, Yihan Zhu, Xiaofei Hao, Mingming Tang, Wei Wu, Decai Wang, Yiwei Yang, Yuwen Liang, Wenqiang Tang, Haonan Xu, Jie Li, Feng Gao, Xiaobo Du   +13 more
doaj   +2 more sources

Research progresses on FLASH radiotherapy and its application for the treatment of digestive system tumors [PDF]

Discover Oncology
Over the past decades, advances in technique have turned radiotherapy into a precise and effective modality for cancer treatment. Nevertheless, the biological effect on organs surrounding the tumor target area is a main dose-limiting element in ...
Siqian Zhang, Yongsheng Zhang, Zhifei Cao   +2 more
doaj   +2 more sources