The FLASH effect—an evaluation of preclinical studies of ultra-high dose rate radiotherapy [PDF]
Frontiers in OncologyFLASH radiotherapy (FLASH-RT) is a novel radiotherapy approach based on the use of ultra-high dose radiation to treat malignant cells. Although tumours can be reduced or eradicated using radiotherapy, toxicities induced by radiation can compromise ...
Josie May McGarrigle +4 more
doaj +7 more sources
The dresden platform is a research hub for ultra-high dose rate radiobiology [PDF]
Scientific Reports, 2023 The recently observed FLASH effect describes the observation of normal tissue protection by ultra-high dose rates (UHDR), or dose delivery in a fraction of a second, at similar tumor-killing efficacy of conventional dose delivery and promises great ...
Josefine Metzkes-Ng +30 more
doaj +6 more sources
The sparing effect of ultra-high dose rate irradiation on the esophagus [PDF]
Frontiers in OncologyBackground and purposeCurrent studies have substantiated the sparing effect of ultra-high dose rate irradiation (FLASH) in various organs including the brain, lungs, and intestines.
Wenting Ren +14 more
doaj +4 more sources
Biological effects of conventional and ultra high dose rate radiation in human cells [PDF]
Scientific ReportsFLASH radiotherapy (FLASH-RT) that uses an ultra-high dose rate (UHDR) radiation is emerging as an effective cancer treatment modality but the biological effects of UHDR are not fully understood.
Terri L. Ryan +13 more
doaj +4 more sources
Development and validation of cost-effective multi-sample hypoxia chambers for proton ultra-high dose rate organoid irradiations [PDF]
Clinical and Translational Radiation OncologyThe tissue sparing of ultra-high dose rate irradiation has been partially observed in vitro while controlling oxygen levels. Here, we developed a hypoxia system for high-throughput irradiations that accommodates embedded 3D cultures, such as organoids ...
Rutger Jan Cornelis de Koster +8 more
doaj +2 more sources
Laser driven FLASH radiobiology using a high dose and ultra high dose rate single pulse proton source [PDF]
Scientific ReportsLaser-driven proton sources have long been developed with an eye on their potential for medical application to radiation therapy. These sources are compact, versatile, and show peculiar characteristics such as extreme instantaneous dose rates, short ...
A. Flacco +14 more
doaj +2 more sources
Development and characterization of phantoms to investigate the Flash effect with Drosophila melanogaster at an ultra-high dose rate radiotherapy linac [PDF]
Physics and Imaging in Radiation OncologyBackground and purpose: Ultra-high dose rate (UHDR) radiotherapy may widen the therapeutic window thanks to the Flash effect. Experimental linear accelerators have been converted to UHDR to collect pre-clinical evidence.
Riccardo Dal Bello +10 more
doaj +2 more sources
Ultra-high dose rate electron FLASH beam irradiation using a modified clinical linear accelerator. [PDF]
PLoS ONEFLASH radiation therapy reduced radiation-induced damage to normal tissue, compared to conventional radiation therapy, and active studies have been undertaken worldwide.
Gyu-Seok Cho +17 more
doaj +2 more sources
DNA damage and cell death induced by exposure to ultra-high dose rate low-dose pulsed X-rays emitted from a kilojoule plasma focus device [PDF]
Biological ResearchBackground FLASH radiotherapy, characterized by ultra-high dose rates (> 40 Gy/s), potentially spares normal tissues while maintaining antitumor efficacy (the FLASH effect).
Héctor Araya +13 more
doaj +2 more sources
Development and application of in-vivo dose and time-resolved measurements for clinical application of ultra-high dose rate radiotherapy [PDF]
Physics and Imaging in Radiation OncologyBackground and purpose: Ultra-high-dose-rate (UHDR) radiotherapy (RT) has emerged as a promising technique to widen the therapeutic window. However, clinical implementation is critically dependent on standardized dosimetry systems.
Riccardo Dal Bello +10 more
doaj +2 more sources