The FLASH effect—an evaluation of preclinical studies of ultra-high dose rate radiotherapy [PDF]
Frontiers in OncologyFLASH radiotherapy (FLASH-RT) is a novel radiotherapy approach based on the use of ultra-high dose radiation to treat malignant cells. Although tumours can be reduced or eradicated using radiotherapy, toxicities induced by radiation can compromise ...
Josie May McGarrigle +4 more
doaj +7 more sources
The dresden platform is a research hub for ultra-high dose rate radiobiology [PDF]
Scientific Reports, 2023 The recently observed FLASH effect describes the observation of normal tissue protection by ultra-high dose rates (UHDR), or dose delivery in a fraction of a second, at similar tumor-killing efficacy of conventional dose delivery and promises great ...
Josefine Metzkes-Ng +30 more
doaj +6 more sources
Biological effects of conventional and ultra high dose rate radiation in human cells [PDF]
Scientific ReportsFLASH radiotherapy (FLASH-RT) that uses an ultra-high dose rate (UHDR) radiation is emerging as an effective cancer treatment modality but the biological effects of UHDR are not fully understood.
Terri L. Ryan +13 more
doaj +4 more sources
The sparing effect of ultra-high dose rate irradiation on the esophagus [PDF]
Frontiers in OncologyBackground and purposeCurrent studies have substantiated the sparing effect of ultra-high dose rate irradiation (FLASH) in various organs including the brain, lungs, and intestines.
Wenting Ren +14 more
doaj +4 more sources
New modalities for ultra-high dose rate irradiation and FLASH experiments [PDF]
Physics and Imaging in Radiation OncologyGabriel Adrian +4 more
doaj +6 more sources
Characterization of Ultra-High-Dose Rate Electron Beams with ElectronFlash Linac
Applied Sciences, 2023 Purpose: The electron linac ElectronFlash installed at Institut Curie (Orsay, France) is entirely dedicated to FLASH irradiation for radiobiological and pre-clinical studies.
Lucia Giuliano +13 more
doaj +3 more sources
Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold? [PDF]
Frontiers in Oncology, 2020 Radiotherapy is a cornerstone of both curative and palliative cancer care. However, radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be reduced, a greater dose of radiation could be given therefore facilitating ...
Joseph D. Wilson +4 more
doaj +4 more sources
Development and validation of cost-effective multi-sample hypoxia chambers for proton ultra-high dose rate organoid irradiations [PDF]
Clinical and Translational Radiation OncologyThe tissue sparing of ultra-high dose rate irradiation has been partially observed in vitro while controlling oxygen levels. Here, we developed a hypoxia system for high-throughput irradiations that accommodates embedded 3D cultures, such as organoids ...
Rutger Jan Cornelis de Koster +8 more
doaj +2 more sources
Laser driven FLASH radiobiology using a high dose and ultra high dose rate single pulse proton source [PDF]
Scientific ReportsLaser-driven proton sources have long been developed with an eye on their potential for medical application to radiation therapy. These sources are compact, versatile, and show peculiar characteristics such as extreme instantaneous dose rates, short ...
A. Flacco +14 more
doaj +2 more sources
Key changes in the future clinical application of ultra-high dose rate radiotherapy
Frontiers in Oncology, 2023 Ultra-high dose rate radiotherapy (FLASH-RT) is an external beam radiotherapy strategy that uses an extremely high dose rate (≥40 Gy/s). Compared with conventional dose rate radiotherapy (≤0.1 Gy/s), the main advantage of FLASH-RT is that it can reduce ...
Binwei Lin +6 more
doaj +3 more sources