Results 11 to 20 of about 117,639 (239)

Ultra-high dose rate electron FLASH beam irradiation using a modified clinical linear accelerator. [PDF]

PLoS ONE
FLASH radiation therapy reduced radiation-induced damage to normal tissue, compared to conventional radiation therapy, and active studies have been undertaken worldwide.
Gyu-Seok Cho, Kyo-Tae Kim, Soon-Sung Lee, Jeong-Hwan Kim, Dong-Han Lee, Hong-Suk Chang, Sang-Hyoun Choi, Kum-Bae Kim, Tae-Keun Yang, Dong-Hyun An, Geun-Beom Kim, Kun-Uk Kang, Jin-Kyu Kang, Eun-Ji Kim, Eun-Kyung Paik, Mi-Sook Kim, Won-Il Jang, Kwang-Mo Yang   +17 more
doaj   +2 more sources

Development and characterization of phantoms to investigate the Flash effect with Drosophila melanogaster at an ultra-high dose rate radiotherapy linac [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Ultra-high dose rate (UHDR) radiotherapy may widen the therapeutic window thanks to the Flash effect. Experimental linear accelerators have been converted to UHDR to collect pre-clinical evidence.
Riccardo Dal Bello, Marvin Kreuzer, Irene Vetrugno, Jamie C. Little, Rafael Kranzer, Stefan Schischke, Lily Bossin, Eduardo Gardenali Yukihara, Matthias Guckenberger, Martin Pruschy, Stephanie Tanadini-Lang   +10 more
doaj   +2 more sources

DNA damage and cell death induced by exposure to ultra-high dose rate low-dose pulsed X-rays emitted from a kilojoule plasma focus device [PDF]

Biological Research
Background FLASH radiotherapy, characterized by ultra-high dose rates (> 40 Gy/s), potentially spares normal tissues while maintaining antitumor efficacy (the FLASH effect).
Héctor Araya, Jalaj Jain, Rodrigo Andaur, José Moreno, Sergio Davis, Pablo Diaz, Ethel Velásquez, Josefa Orellana, Martín Ríos, Jessica Toro, Octavio Orellana-Serradell, Cristopher Fierro, Leopoldo Soto, Katherine Marcelain   +13 more
doaj   +2 more sources

Hydrated electron yield dependence on instantaneous dose rates with electron ultra-high dose rate (UHDR) irradiation. [PDF]

Phys Med Biol
Abstract Objective. The aim of this study was to quantify the characteristic transient production yield of hydrated electrons (G-value) in water under ultra-high dose rates (UHDR) with electron irradiation. Changes in this yield with UHDR irradiation may provide insights into the radiation chemistry origins of the ...
Cao X, Parks A, Thomas W, Reed MS, Culberson WS, Pogue BW.   +5 more
europepmc   +3 more sources

Ultra‑high dose rate (FLASH) treatment: A novel radiotherapy modality (Review). [PDF]

Mol Clin Oncol
Ultra-high dose rate radiotherapy defined as FLASH radiotherapy is a potential technology to improve local tumor therapeutic gain ratio. It relies on linear accelerator capable of delivering large doses in a single microsecond pulse (>40 Gy/sec). This therapy would lead to sparing of normal tissue which has been termed the FLASH effect.
Huang J, Cheng J, Shi B, Du X, Tang S, Lin B, Mo J, Yan F, Luo S, Yang H.   +9 more
europepmc   +3 more sources

Development and application of in-vivo dose and time-resolved measurements for clinical application of ultra-high dose rate radiotherapy [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Ultra-high-dose-rate (UHDR) radiotherapy (RT) has emerged as a promising technique to widen the therapeutic window. However, clinical implementation is critically dependent on standardized dosimetry systems.
Riccardo Dal Bello, Serena Psoroulas, Dominik Flückiger, Jerome Krayenbühl, Arvid Kemper, Rafael Kranzer, Benjamin Côté, Jens von der Grün, Panagiotis Balermpas, Matthias Guckenberger, Stephanie Tanadini-Lang   +10 more
doaj   +2 more sources

Effects of ultra-high dose rate radiotherapy with different fractions and dose rate on acute and chronic lung injury in mice [PDF]

Heliyon
Ultra-high dose rate radiotherapy (FLASH radiation) can naturally render normal tissues around the tumor tissue resistant to radiotherapy. In contrast, the tumor tissue remains sensitive to radiation under the same conditions.
Feng Gao, Binwei Lin, Yiwei Yang, Dexin Xiao, Zheng Zhou, Yu Zhang, Gang Feng, Jie Li, Dai Wu, Xiaobo Du, Qiuling Shi   +10 more
doaj   +2 more sources

Ultra-High Dose Rate Electron Beam Dosimetry Using Ag Nanoparticle-Enhanced nPAG and NIBMAGAT Gels [PDF]

Gels
FLASH radiation therapy is an emerging technique that provides several advantages over conventional radiotherapy. By delivering ultra-high dose rate radiation, the damage to healthy tissues surrounding the treatment area is minimized, treatment time is ...
Mantvydas Merkis, Akvile Slektaite-Kisone, Marius Burkanas, Aleksandras Cicinas, Mindaugas Dziugelis, Vaidas Klimkevicius, Diana Adliene, Jonas Venius   +7 more
doaj   +2 more sources

First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy [PDF]

Physics and Imaging in Radiation Oncology
Within this study, we demonstrated the feasibility of ultra-high dose rate (UHDR) oxygen ion irradiation at three different levels of biological complexity. The difference in oxygen consumption between UHDR and standard dose rates (SDR) was negligible in
Celine Karle, Domenico I. Filosa, Mahdi Akbarpour, Nora Schuhmacher, Stephan Brons, Rainer Cee, Christian Schömers, Stefan Scheloske, Kristoffer Petersson, Thomas Haberer, Amir Abdollahi, Jürgen Debus, Thomas Tessonnier, Mahmoud Moustafa, Andrea Mairani, Ivana Dokic   +15 more
doaj   +2 more sources

MOSkin dosimetry for an ultra-high dose-rate, very high-energy electron irradiation environment at PEER

Frontiers in Physics
FLASH radiotherapy, which refers to the delivery of radiation at ultra-high dose-rates (UHDRs), has been demonstrated with various forms of radiation and is the subject of intense research and development recently, including the use of very high-energy ...
James Cayley, Yaw-Ren E. Tan, Marco Petasecca, Dean Cutajar, Thomas Breslin, Anatoly Rosenfeld, Michael Lerch   +6 more
doaj   +3 more sources