New modalities for ultra-high dose rate irradiation and FLASH experiments [PDF]
Physics and Imaging in Radiation OncologyGabriel Adrian +4 more
doaj +6 more sources
Characterization of Ultra-High-Dose Rate Electron Beams with ElectronFlash Linac
Applied Sciences, 2023 Purpose: The electron linac ElectronFlash installed at Institut Curie (Orsay, France) is entirely dedicated to FLASH irradiation for radiobiological and pre-clinical studies.
Lucia Giuliano +13 more
doaj +3 more sources
The dresden platform is a research hub for ultra-high dose rate radiobiology [PDF]
Scientific Reports, 2023 The recently observed FLASH effect describes the observation of normal tissue protection by ultra-high dose rates (UHDR), or dose delivery in a fraction of a second, at similar tumor-killing efficacy of conventional dose delivery and promises great ...
Josefine Metzkes-Ng +30 more
doaj +4 more sources
Key changes in the future clinical application of ultra-high dose rate radiotherapy
Frontiers in Oncology, 2023 Ultra-high dose rate radiotherapy (FLASH-RT) is an external beam radiotherapy strategy that uses an extremely high dose rate (≥40 Gy/s). Compared with conventional dose rate radiotherapy (≤0.1 Gy/s), the main advantage of FLASH-RT is that it can reduce ...
Binwei Lin +6 more
doaj +3 more sources
Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold? [PDF]
Frontiers in Oncology, 2020 Radiotherapy is a cornerstone of both curative and palliative cancer care. However, radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be reduced, a greater dose of radiation could be given therefore facilitating ...
Joseph D. Wilson +4 more
doaj +4 more sources
Ultra-High Dose Rate Electron Beam Dosimetry Using Ag Nanoparticle-Enhanced nPAG and NIBMAGAT Gels [PDF]
GelsFLASH radiation therapy is an emerging technique that provides several advantages over conventional radiotherapy. By delivering ultra-high dose rate radiation, the damage to healthy tissues surrounding the treatment area is minimized, treatment time is ...
Mantvydas Merkis +7 more
doaj +2 more sources
First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy [PDF]
Physics and Imaging in Radiation OncologyWithin this study, we demonstrated the feasibility of ultra-high dose rate (UHDR) oxygen ion irradiation at three different levels of biological complexity. The difference in oxygen consumption between UHDR and standard dose rates (SDR) was negligible in
Celine Karle +15 more
doaj +2 more sources
Consensus statement on the exploration of clinical translation and application of electron ultra‐high dose rate FLASH radiotherapy [PDF]
Precision Radiation OncologyUltra‐high dose rate FLASH Radiotherapy (FLASH‐RT) has attracted wide attention because the well‐known FLASH effect and the extremely short irradiation time.
Hui Luo +3 more
doaj +2 more sources
Ultra-high dose rate radiotherapy overcomes radioresistance in head and neck squamous cell carcinoma [PDF]
Signal Transduction and Targeted TherapyRadiotherapy (RT) resistance in head and neck squamous cell carcinoma (HNSCC) significantly hampers local control and patient prognosis. This study investigated the efficacy and molecular mechanisms of high-energy X-ray-based ultra-high dose rate ...
Hong-Shuai Li +20 more
doaj +2 more sources
Development of Ultra-High Dose-Rate (FLASH) Particle Therapy
IEEE Transactions on Radiation and Plasma Medical Sciences, 2022 Research efforts in FLASH radiotherapy have increased at an accelerated pace recently. FLASH radiotherapy involves ultra-high dose rates and has shown to reduce toxicity to normal tissue while maintaining tumor response in pre-clinical studies when compared to conventional dose rate radiotherapy.
Michele M. Kim +8 more
openaire +4 more sources