Results 21 to 30 of about 117,639 (239)
Consensus statement on the exploration of clinical translation and application of electron ultra‐high dose rate FLASH radiotherapy [PDF]
Precision Radiation OncologyUltra‐high dose rate FLASH Radiotherapy (FLASH‐RT) has attracted wide attention because the well‐known FLASH effect and the extremely short irradiation time.
Hui Luo +3 more
doaj +2 more sources
Ultra-high dose rate radiotherapy overcomes radioresistance in head and neck squamous cell carcinoma [PDF]
Signal Transduction and Targeted TherapyRadiotherapy (RT) resistance in head and neck squamous cell carcinoma (HNSCC) significantly hampers local control and patient prognosis. This study investigated the efficacy and molecular mechanisms of high-energy X-ray-based ultra-high dose rate ...
Hong-Shuai Li +20 more
doaj +2 more sources
Development of Ultra-High Dose-Rate (FLASH) Particle Therapy
IEEE Transactions on Radiation and Plasma Medical Sciences, 2022 Research efforts in FLASH radiotherapy have increased at an accelerated pace recently. FLASH radiotherapy involves ultra-high dose rates and has shown to reduce toxicity to normal tissue while maintaining tumor response in pre-clinical studies when compared to conventional dose rate radiotherapy.
Michele M. Kim +8 more
openaire +4 more sources
Faster and safer? FLASH ultra-high dose rate in radiotherapy [PDF]
The British Journal of Radiology, 2017 Recent results from the Franco-Swiss team of Institute Curie and Centre Hospitalier Universitaire Vaudois demonstrate a remarkable sparing of normal tissue after irradiation at ultra-high dose rate (>40 Gy s-1). The "FLASH" radiotherapy maintains tumour control level, suggesting that ultra-high dose rate can substantially enhance the therapeutic window
Durante, Marco +2 more
openaire +3 more sources
Radiobiology and treatment plan progress of FLASH radiotherapy
Fushe yanjiu yu fushe gongyi xuebao, 2023 FLASH radiotherapy is a novel method that has the potential to improve the therapeutic gain ratio to a new level. FLASH radiotherapy technology is mainly characterized by irradiation at ultra-high dose rate, which can reduce radiation-induced injury to ...
WU Xun +3 more
doaj +1 more source
Ultra-high dose rate FLASH irradiator at the radiological research accelerator facility
Scientific Reports, 2022 The Radiological Research Accelerator Facility has modified a decommissioned Varian Clinac to deliver ultra-high dose rates: operating in 9 MeV electron mode (FLASH mode), samples can be irradiated at a Source-Surface Distance (SSD) of 20 cm at average ...
Guy Garty +6 more
doaj +1 more source
Understanding the FLASH effect to unravel the potential of ultra-high dose rate irradiation [PDF]
International Journal of Radiation Biology, 2021 A reemergence of research implementing radiation delivery at ultra-high dose rates (UHDRs) has triggered intense interest in the radiation sciences and has opened a new field of investigation in radiobiology. Much of the promise of UHDR irradiation involves the FLASH effect, an in vivo biological response observed to maintain anti-tumor efficacy ...
Houda Kacem +3 more
openaire +2 more sources
Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons
Nuclear Engineering and Technology, 2023 Recently, as the clinically positive biological effects of ultra-high dose rate (UHDR) radiation beams have been revealed, interest in flash radiation therapy has increased. Generally, FLASH preclinical experiments are performed using UHDR electron beams
Hyun Kim +6 more
doaj +1 more source
Medical Physics, 2023 AbstractBackgroundThe possible emergence of the FLASH effect—the sparing of normal tissue while maintaining tumor control—after irradiations at dose‐rates exceeding several tens of Gy per second, has recently spurred a surge of studies attempting to characterize and rationalize the phenomenon. Investigating and reporting the dose and instantaneous dose‐
Tessonnier T. +5 more
openaire +5 more sources
FLASH radiotherapy: Research process from basic experimentation to clinical application
Precision Radiation Oncology, 2021 FLASH radiotherapy (FLASH‐RT) has gained attention as an ultra‐high dose rate RT in recent years. This treatment significantly shortens the time of RT and reduces the influence of tumor movement caused by breathing or other factors.
Xiaohui Wang +3 more
doaj +1 more source