Results 21 to 30 of about 126,687 (241)
Faster and safer? FLASH ultra-high dose rate in radiotherapy [PDF]
The British Journal of Radiology, 2017 Recent results from the Franco-Swiss team of Institute Curie and Centre Hospitalier Universitaire Vaudois demonstrate a remarkable sparing of normal tissue after irradiation at ultra-high dose rate (>40 Gy s-1). The "FLASH" radiotherapy maintains tumour control level, suggesting that ultra-high dose rate can substantially enhance the therapeutic window
Durante, Marco +2 more
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Ultra-high dose rate FLASH irradiator at the radiological research accelerator facility
Scientific Reports, 2022 The Radiological Research Accelerator Facility has modified a decommissioned Varian Clinac to deliver ultra-high dose rates: operating in 9 MeV electron mode (FLASH mode), samples can be irradiated at a Source-Surface Distance (SSD) of 20 cm at average ...
Guy Garty +6 more
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Radiobiology and treatment plan progress of FLASH radiotherapy
Fushe yanjiu yu fushe gongyi xuebao, 2023 FLASH radiotherapy is a novel method that has the potential to improve the therapeutic gain ratio to a new level. FLASH radiotherapy technology is mainly characterized by irradiation at ultra-high dose rate, which can reduce radiation-induced injury to ...
WU Xun +3 more
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Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons
Nuclear Engineering and Technology, 2023 Recently, as the clinically positive biological effects of ultra-high dose rate (UHDR) radiation beams have been revealed, interest in flash radiation therapy has increased. Generally, FLASH preclinical experiments are performed using UHDR electron beams
Hyun Kim +6 more
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FLASH radiotherapy: Research process from basic experimentation to clinical application
Precision Radiation Oncology, 2021 FLASH radiotherapy (FLASH‐RT) has gained attention as an ultra‐high dose rate RT in recent years. This treatment significantly shortens the time of RT and reduces the influence of tumor movement caused by breathing or other factors.
Xiaohui Wang +3 more
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Medical Physics, 2023 AbstractBackgroundThe possible emergence of the FLASH effect—the sparing of normal tissue while maintaining tumor control—after irradiations at dose‐rates exceeding several tens of Gy per second, has recently spurred a surge of studies attempting to characterize and rationalize the phenomenon. Investigating and reporting the dose and instantaneous dose‐
Tessonnier T. +5 more
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Potential Molecular Mechanisms behind the Ultra-High Dose Rate “FLASH” Effect
International Journal of Molecular Sciences, 2022 FLASH radiotherapy, or the delivery of a dose at an ultra-high dose rate (>40 Gy/s), has recently emerged as a promising tool to enhance the therapeutic index in cancer treatment. The remarkable sparing of normal tissues and equivalent tumor control by FLASH irradiation compared to conventional dose rate irradiation—the FLASH effect—has already been
Bogaerts, Eva +3 more
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Sensors, 2021 FLASH radiotherapy is an emerging radiotherapy technique used to spare normal tissues. It employs ultra-high dose rate radiation beams over 40 Gy/s, which is significantly higher than those of conventional radiotherapy.
Dong-Hyeok Jeong +9 more
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Neuroprotection of Radiosensitive Juvenile Mice by Ultra-High Dose Rate FLASH Irradiation [PDF]
Cancers, 2020 Major advances in high precision treatment delivery and imaging have greatly improved the tolerance of radiotherapy (RT); however, the selective sparing of normal tissue and the reduction of neurocognitive side effects from radiation-induced toxicities remain significant problems for pediatric patients with brain tumors.
Yasaman Alaghband +10 more
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Understanding the FLASH effect to unravel the potential of ultra-high dose rate irradiation [PDF]
International Journal of Radiation Biology, 2021 A reemergence of research implementing radiation delivery at ultra-high dose rates (UHDRs) has triggered intense interest in the radiation sciences and has opened a new field of investigation in radiobiology. Much of the promise of UHDR irradiation involves the FLASH effect, an in vivo biological response observed to maintain anti-tumor efficacy ...
Houda Kacem +3 more
openaire +2 more sources