The FLASH effect—an evaluation of preclinical studies of ultra-high dose rate radiotherapy [PDF]
Frontiers in OncologyFLASH radiotherapy (FLASH-RT) is a novel radiotherapy approach based on the use of ultra-high dose radiation to treat malignant cells. Although tumours can be reduced or eradicated using radiotherapy, toxicities induced by radiation can compromise ...
Josie May McGarrigle +4 more
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Key changes in the future clinical application of ultra-high dose rate radiotherapy [PDF]
Frontiers in Oncology, 2023 Ultra-high dose rate radiotherapy (FLASH-RT) is an external beam radiotherapy strategy that uses an extremely high dose rate (≥40 Gy/s). Compared with conventional dose rate radiotherapy (≤0.1 Gy/s), the main advantage of FLASH-RT is that it can reduce ...
Binwei Lin +6 more
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Effects of ultra-high dose rate radiotherapy with different fractions and dose rate on acute and chronic lung injury in mice [PDF]
HeliyonUltra-high dose rate radiotherapy (FLASH radiation) can naturally render normal tissues around the tumor tissue resistant to radiotherapy. In contrast, the tumor tissue remains sensitive to radiation under the same conditions.
Feng Gao +10 more
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Ultra-high dose rate radiotherapy overcomes radioresistance in head and neck squamous cell carcinoma [PDF]
Signal Transduction and Targeted TherapyRadiotherapy (RT) resistance in head and neck squamous cell carcinoma (HNSCC) significantly hampers local control and patient prognosis. This study investigated the efficacy and molecular mechanisms of high-energy X-ray-based ultra-high dose rate ...
Hong-Shuai Li +20 more
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Development and application of in-vivo dose and time-resolved measurements for clinical application of ultra-high dose rate radiotherapy [PDF]
Physics and Imaging in Radiation OncologyBackground and purpose: Ultra-high-dose-rate (UHDR) radiotherapy (RT) has emerged as a promising technique to widen the therapeutic window. However, clinical implementation is critically dependent on standardized dosimetry systems.
Riccardo Dal Bello +10 more
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Effects and potential mechanisms of the ultra-high dose rate radiotherapy on lung injury: a review [PDF]
Radiation OncologyUltra-high dose rate (FLASH) radiotherapy is a novel modality delivering dose rates several orders of magnitude higher than conventional dose rate (CONV) radiotherapy.
Zhipeng Li +7 more
doaj +2 more sources
FLASH radiotherapy as an emerging paradigm in radioimmunotherapy: biological rationale, preclinical evidence, and translational roadmap [PDF]
Frontiers in ImmunologyUltra-high dose rate radiotherapy (FLASH-RT) has emerged as a promising technology in recent years. Unlike conventional radiotherapy (CONV-RT), FLASH-RT delivers radiation at an ultra-high dose rate over a very short duration.
Dongliang Li +8 more
doaj +2 more sources
Sensors, 2021 FLASH radiotherapy is an emerging radiotherapy technique used to spare normal tissues. It employs ultra-high dose rate radiation beams over 40 Gy/s, which is significantly higher than those of conventional radiotherapy.
Dong-Hyeok Jeong +9 more
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Radiobiology and treatment plan progress of FLASH radiotherapy
Fushe yanjiu yu fushe gongyi xuebao, 2023 FLASH radiotherapy is a novel method that has the potential to improve the therapeutic gain ratio to a new level. FLASH radiotherapy technology is mainly characterized by irradiation at ultra-high dose rate, which can reduce radiation-induced injury to ...
WU Xun +3 more
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Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?
Frontiers in Oncology, 2020 Radiotherapy is a cornerstone of both curative and palliative cancer care. However, radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be reduced, a greater dose of radiation could be given therefore facilitating ...
Joseph D. Wilson +4 more
doaj +1 more source