Results 11 to 20 of about 12,390 (209)

FLASH radiotherapy: Research process from basic experimentation to clinical application

Precision Radiation Oncology, 2021
FLASH radiotherapy (FLASH‐RT) has gained attention as an ultra‐high dose rate RT in recent years. This treatment significantly shortens the time of RT and reduces the influence of tumor movement caused by breathing or other factors.
Xiaohui Wang, Hui Luo, Xiaoli Zheng, Hong Ge   +3 more
doaj   +1 more source

Mechanisms of FLASH effect

Frontiers in Oncology, 2022
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high dose rate (≥ 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects: first, compared with conventional dose rate radiotherapy, FLASH-RT can ...
Binwei Lin, Binwei Lin, Dan Huang, Feng Gao, Yiwei Yang, Dai Wu, Yu Zhang, Gang Feng, Tangzhi Dai, Xiaobo Du   +9 more
doaj   +1 more source

Prediction of the treatment effect of FLASH radiotherapy with synchrotron radiation from the Circular Electron–Positron Collider (CEPC)

Journal of Synchrotron Radiation
The Circular Electron–Positron Collider (CEPC) in China can also work as an excellent powerful synchrotron light source, which can generate high-quality synchrotron radiation. This synchrotron radiation has potential advantages in the medical field as it
Junyu Zhang, Xiangyu Wu, Pengyuan Qi, Jike Wang   +3 more
doaj   +1 more source

Absolute dosimetry for FLASH proton pencil beam scanning radiotherapy

Scientific Reports, 2023
A paradigm shift is occurring in clinical oncology exploiting the recent discovery that short pulses of ultra-high dose rate (UHDR) radiation—FLASH radiotherapy—can significantly spare healthy tissues whilst still being at least as effective in curing ...
Ana Lourenço, Anna Subiel, Nigel Lee, Sam Flynn, John Cotterill, David Shipley, Francesco Romano, Joe Speth, Eunsin Lee, Yongbin Zhang, Zhiyan Xiao, Anthony Mascia, Richard A. Amos, Hugo Palmans, Russell Thomas   +14 more
doaj   +1 more source

Flash Radiotherapy: Innovative Cancer Treatment

Encyclopedia, 2023
Flash radiotherapy (Flash-RT) is an innovative technique used in radiotherapy for cancer treatment because it delivers an extremely high dose of radiation (>40 Gy/s) to the tumour in a very short period of time, typically within a fraction of a second ...
James C. L. Chow, Harry E. Ruda
doaj   +1 more source

Translational Research in FLASH Radiotherapy—From Radiobiological Mechanisms to In Vivo Results

Biomedicines, 2021
FLASH radiotherapy, or the administration of ultra-high dose rate radiotherapy, is a new radiation delivery method that aims to widen the therapeutic window in radiotherapy.
Loredana G. Marcu, Eva Bezak, Dylan D. Peukert, Puthenparampil Wilson   +3 more
doaj   +1 more source

Cancer Cells Can Exhibit a Sparing FLASH Effect at Low Doses Under Normoxic In Vitro-Conditions

Frontiers in Oncology, 2021
BackgroundIrradiation with ultra-high dose rate (FLASH) has been shown to spare normal tissue without hampering tumor control in several in vivo studies. Few cell lines have been investigated in vitro, and previous results are inconsistent. Assuming that
Gabriel Adrian, Gabriel Adrian, Elise Konradsson, Sarah Beyer, Anders Wittrup, Anders Wittrup, Anders Wittrup, Karl T. Butterworth, Stephen J. McMahon, Mihaela Ghita, Kristoffer Petersson, Kristoffer Petersson, Crister Ceberg   +12 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

The influence of beam parameters on FLASH effect

Frontiers in Oncology
Ultra-high dose rate radiotherapy (FLASH-RT) is typically defined as an external beam radiotherapy that utilizes a dose rate of 40 Gy/s or higher, compared with conventional dose rate radiotherapy (≤0.1 Gy/s).
Binwei Lin, Binwei Lin, Huan Du, Huan Du, Xiaofei Hao, Xiaofei Hao, Yuwen Liang, Haonan Xu, Wenqiang Tang, Jie Li, Jie Li, Yu Zhang, Yu Zhang, Xiao Bo Du, Xiao Bo Du, Xiao Bo Du   +15 more
doaj   +1 more source

Comparison of intratumor and local immune response between MV X-ray FLASH and conventional radiotherapies

Clinical and Translational Radiation Oncology, 2023
Background/Purpose: Investigating the antitumor effect and intratumor as well as local immune response in breast cancer-bearing mice after MV X-ray ultra-high dose rate radiotherapy (FLASH-RT) and conventional dose rate radiotherapy (CONV-RT).
Hongyu Zhu, Dehuan Xie, Ying Wang, Runda Huang, Xi Chen, Yiwei Yang, Bin Wang, Yinglin Peng, Jianxin Wang, Dexin Xiao, Dai Wu, Chao-Nan Qian, Xiaowu Deng   +12 more
doaj   +1 more source