Results 31 to 40 of about 117,639 (239)
Potential Molecular Mechanisms behind the Ultra-High Dose Rate “FLASH” Effect
International Journal of Molecular Sciences, 2022 FLASH radiotherapy, or the delivery of a dose at an ultra-high dose rate (>40 Gy/s), has recently emerged as a promising tool to enhance the therapeutic index in cancer treatment. The remarkable sparing of normal tissues and equivalent tumor control by FLASH irradiation compared to conventional dose rate irradiation—the FLASH effect—has already been
Bogaerts, Eva +3 more
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Sensors, 2021 FLASH radiotherapy is an emerging radiotherapy technique used to spare normal tissues. It employs ultra-high dose rate radiation beams over 40 Gy/s, which is significantly higher than those of conventional radiotherapy.
Dong-Hyeok Jeong +9 more
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Neuroprotection of Radiosensitive Juvenile Mice by Ultra-High Dose Rate FLASH Irradiation [PDF]
Cancers, 2020 Major advances in high precision treatment delivery and imaging have greatly improved the tolerance of radiotherapy (RT); however, the selective sparing of normal tissue and the reduction of neurocognitive side effects from radiation-induced toxicities remain significant problems for pediatric patients with brain tumors.
Yasaman Alaghband +10 more
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In situ correction of recombination effects in ultra-high dose rate irradiations with protons
Physics in Medicine & Biology, 2023 Abstract Background. At the Center for Proton Therapy at the Paul Scherrer Institute (PSI) the delivery of proton radiation is controlled via gas-based ionization chambers: the beam is turned off when a certain amount of preset charge has been collected.
R, Schaefer, S, Psoroulas, D C, Weber
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Intertrack interaction at ultra-high dose rates and its role in the FLASH effect
Frontiers in Physics, 2023 Background: The mechanism responsible for the FLASH effect remains undetermined yet critical to the clinical translation of FLASH radiotherapy. The potential role of intertrack interactions in the FLASH effect, arising from the high spatio-temporal concentrations of particle tracks at UHDRs, has been widely discussed but its influence is unknown ...
Alexander Baikalov +9 more
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Calorimeter for Real-Time Dosimetry of Pulsed Ultra-High Dose Rate Electron Beams
Frontiers in Physics, 2020 An aluminum calorimeter was investigated as a possible real-time dosimeter for electron beams with an ultra-high dose per pulse (DPP), as used in FLASH radiation therapy (a few Gy/pulse). Ionization chambers, the most widely used active dosimeter type in
Alexandra Bourgouin +9 more
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Ultra-high dose rate (FLASH) radiotherapy: Revolutionizing tumor targeting and microenvironmental dynamics in cancer treatment [PDF]
Chinese Medical JournalZhiming Wang +4 more
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Cellular irradiations with laser-driven carbon ions at ultra-high dose rates
Physics in Medicine & Biology, 2023 Abstract Objective. Carbon is an ion species of significant radiobiological interest, particularly in view of its use in cancer radiotherapy, where its large Relative Biological Efficiency is often exploited to overcome radio resistance.
Chaudhary, Pankaj +13 more
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Frontiers in PhysicsVery High-Energy Electrons (VHEE) present a promising innovation in radiation therapy (RT), particularly for the treatment of deep-seated tumors using Ultra High Dose Rate (UHDR) within the framework of FLASH-RT.
J. H. Pensavalle +34 more
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Radiation Oncology, 2022 Background There is currently significant interest in assessing the role of oxygen in the radiobiological effects at ultra-high dose rates. Oxygen modulation is postulated to play a role in the enhanced sparing effect observed in FLASH radiotherapy ...
Pankaj Chaudhary +22 more
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