Results 21 to 30 of about 117,639 (239)

Development of Ultra-High Dose-Rate (FLASH) Particle Therapy

IEEE Transactions on Radiation and Plasma Medical Sciences, 2022
Research efforts in FLASH radiotherapy have increased at an accelerated pace recently. FLASH radiotherapy involves ultra-high dose rates and has shown to reduce toxicity to normal tissue while maintaining tumor response in pre-clinical studies when compared to conventional dose rate radiotherapy.
Michele M. Kim, Arash Darafsheh, Jan Schuemann, Ivana Dokic, Olle Lundh, Tianyu Zhao, Jose Ramos-Mendez, Lei Dong, Kristoffer Petersson   +8 more
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Diamond detectors for dose and instantaneous dose‐rate measurements for ultra‐high dose‐rate scanned helium ion beams

Medical Physics, 2023
AbstractBackgroundThe possible emergence of the FLASH effect—the sparing of normal tissue while maintaining tumor control—after irradiations at dose‐rates exceeding several tens of Gy per second, has recently spurred a surge of studies attempting to characterize and rationalize the phenomenon. Investigating and reporting the dose and instantaneous dose‐
Tessonnier T., Verona Rinati G., Rank L., Kranzer R., Mairani A., Marinelli M.   +5 more
openaire   +5 more sources

Understanding High-Dose, Ultra-High Dose Rate, and Spatially Fractionated Radiation Therapy [PDF]

International Journal of Radiation Oncology*Biology*Physics, 2020
The National Cancer Institute's Radiation Research Program, in collaboration with the Radiosurgery Society, hosted a workshop called Understanding High-Dose, Ultra-High Dose Rate and Spatially Fractionated Radiotherapy on August 20 and 21, 2018 to bring together experts in experimental and clinical experience in these and related fields.
Griffin, Robert J, Ahmed, Mansoor M, Amendola, Beatriz, Belyakov, Oleg, Bentzen, Søren M, Butterworth, Karl T, Chang, Sha, Coleman, C Norman, Djonov, Valentin, Formenti, Sylvia C, Glatstein, Eli, Guha, Chandan, Kalnicki, Shalom, Le, Quynh-Thu, Loo, Billy W (Jr), Mahadevan, Anand, Massaccesi, Mariangela, Maxim, Peter G, Mohiuddin, Majid, Mohiuddin, Mohammed, Mayr, Nina A, Obcemea, Ceferino, Petersson, Kristoffer, Regine, William, Roach, Mack, Romanelli, Pantaleo, Simone, Charles B (2nd), Snider, James W, Spitz, Douglas R, Vikram, Bhadrasain, Vozenin, Marie-Catherine, Abdel-Wahab, May, Welsh, James, Wu, Xiaodong, Limoli, Charles L   +34 more
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Faster and safer? FLASH ultra-high dose rate in radiotherapy [PDF]

The British Journal of Radiology, 2017
Recent results from the Franco-Swiss team of Institute Curie and Centre Hospitalier Universitaire Vaudois demonstrate a remarkable sparing of normal tissue after irradiation at ultra-high dose rate (>40 Gy s-1). The "FLASH" radiotherapy maintains tumour control level, suggesting that ultra-high dose rate can substantially enhance the therapeutic window
Durante, Marco, BräUer-Krisch, Elke, Hill, Mark   +2 more
openaire   +3 more sources

Radiobiology and treatment plan progress of FLASH radiotherapy

Fushe yanjiu yu fushe gongyi xuebao, 2023
FLASH radiotherapy is a novel method that has the potential to improve the therapeutic gain ratio to a new level. FLASH radiotherapy technology is mainly characterized by irradiation at ultra-high dose rate, which can reduce radiation-induced injury to ...
WU Xun, LIU Ruifeng, ZHANG Qiuning, WANG Xiaohu   +3 more
doaj   +1 more source

Understanding the FLASH effect to unravel the potential of ultra-high dose rate irradiation [PDF]

International Journal of Radiation Biology, 2021
A reemergence of research implementing radiation delivery at ultra-high dose rates (UHDRs) has triggered intense interest in the radiation sciences and has opened a new field of investigation in radiobiology. Much of the promise of UHDR irradiation involves the FLASH effect, an in vivo biological response observed to maintain anti-tumor efficacy ...
Houda Kacem, Aymeric Almeida, Nicolas Cherbuin, Marie-Catherine Vozenin   +3 more
openaire   +2 more sources

Ultra-high dose rate FLASH irradiator at the radiological research accelerator facility

Scientific Reports, 2022
The Radiological Research Accelerator Facility has modified a decommissioned Varian Clinac to deliver ultra-high dose rates: operating in 9 MeV electron mode (FLASH mode), samples can be irradiated at a Source-Surface Distance (SSD) of 20 cm at average ...
Guy Garty, Razib Obaid, Naresh Deoli, Ekaterina Royba, Yuewen Tan, Andrew D. Harken, David J. Brenner   +6 more
doaj   +1 more source

Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons

Nuclear Engineering and Technology, 2023
Recently, as the clinically positive biological effects of ultra-high dose rate (UHDR) radiation beams have been revealed, interest in flash radiation therapy has increased. Generally, FLASH preclinical experiments are performed using UHDR electron beams
Hyun Kim, Dong Hyeok Jeong, Sang Koo Kang, Manwoo Lee, Heuijin Lim, Sang Jin Lee, Kyoung Won Jang   +6 more
doaj   +1 more source

FLASH radiotherapy: Research process from basic experimentation to clinical application

Precision Radiation Oncology, 2021
FLASH radiotherapy (FLASH‐RT) has gained attention as an ultra‐high dose rate RT in recent years. This treatment significantly shortens the time of RT and reduces the influence of tumor movement caused by breathing or other factors.
Xiaohui Wang, Hui Luo, Xiaoli Zheng, Hong Ge   +3 more
doaj   +1 more source

Hydrated electron yield dependence on instantaneous dose rates with electron ultra-high dose rate (UHDR) irradiation. [PDF]

Phys Med Biol
Abstract Objective. The aim of this study was to quantify the characteristic transient production yield of hydrated electrons (G-value) in water under ultra-high dose rates (UHDR) with electron irradiation. Changes in this yield with UHDR irradiation may provide insights into the radiation chemistry origins of the ...
Cao X, Parks A, Thomas W, Reed MS, Culberson WS, Pogue BW.   +5 more
europepmc   +3 more sources