Results 21 to 30 of about 422,772 (173)

Non-conventional Ultra-High Dose Rate (FLASH) Microbeam Radiotherapy Provides Superior Normal Tissue Sparing in Rat Lung Compared to Non-conventional Ultra-High Dose Rate (FLASH) Radiotherapy [PDF]

, 2021
Conventional radiotherapy is a widely used non-invasive form of treatment for many types of cancer. However, due to a low threshold in the lung for radiation-induced normal tissue damage, it is of less utility in treating lung cancer.
Bravin, A., Wright, M.D., Wright, Michael D., Requardt, Herwig, Hlushchuk, R., Romanelli, Pantaleo, Romanelli, P., Bartzsch, S., Bartzsch, Stefan, Le Duc, G., Djonov, Valentin, Laissue, Jean-Albert, Requardt, H., Bravin, Alberto, Hlushchuk, Ruslan, Brauer-Krisch, Elke, Bräuer-Krisch, E., Le Duc, Geraldine, Djonov, V., Laissue, J.A., Michael D Wright, Jean-Albert Laissue, Elke Brauer-Krisch, Geraldine Le Duc, Ruslan Hlushchuk, Valentin Djonov, Pantaleo Romanelli, Herwig Requardt, Alberto Bravin, Stefan Bartzsch   +29 more
core   +3 more sources

Comparable survival in rats with intracranial glioblastoma irradiated with single-fraction conventional radiotherapy or FLASH radiotherapy [PDF]

, 2023
Background: Radiotherapy increases survival in patients with glioblastoma. However, the prescribed dose is limited by unwanted side effects on normal tissue.
Gustafsson, Emma, Redebrandt, Henrietta Nittby, Liljedahl, Emma, Linderfalk, Karin, Petersson, Kristoffer, Konradsson, Elise, Ceberg, Crister   +6 more
core   +3 more sources

New insights on clinical perspectives of FLASH radiotherapy: from low- to very high electron energy

Frontiers in Oncology, 2023
Radiotherapy (RT) is performed in approximately 75% of patients with cancer, and its efficacy is often hampered by the low tolerance of the surrounding normal tissues.
Stefano Ursino, Stefano Ursino, Stefano Ursino, Giovanni Gadducci, Giovanni Gadducci, Noemi Giannini, Noemi Giannini, Alessandra Gonnelli, Alessandra Gonnelli, Taiushia Fuentes, Taiushia Fuentes, Fabio Di Martino, Fabio Di Martino, Fabiola Paiar, Fabiola Paiar, Fabiola Paiar   +15 more
doaj   +1 more source

Towards FLASH Radiotherapy in Lung Cancer: A Review on Preclinical Evidence and Technical Feasibility. [PDF]

Cancers (Basel)
Background/Objectives: Alongside surgery and systemic treatments, radiotherapy plays a crucial role in the treatment of lung cancer but can affect healthy tissue and cause serious side effects.
Visser SN, Habraken SJM, Puspitasari-Kokko A, Zur Horst AH, Rasch CRN, van Doorn-Wink KCJ.   +5 more
europepmc   +2 more sources

An insight into hypothesized biological mechanisms contributing to the Flash effect

Frontiers in Physics, 2023
In recent years, FLASH radiotherapy (FLASH RT) has gained attention in preclinical studies as a potential advancement in cancer treatment. The great advantage of FLASH RT is the ultra-fast, high doses delivery that have a similar or greater effect on ...
Francesca Del Debbio, Maria Sofia Bertilacchi, Alessandra Gonnelli, Alessandra Gonnelli, Eleonora Da Pozzo, Eleonora Da Pozzo, Eleonora Da Pozzo, Valentina Tozzini, Valentina Tozzini, Claudia Martini, Claudia Martini, Claudia Martini, Simone Capaccioli, Simone Capaccioli, Simone Capaccioli, Barbara Costa, Barbara Costa   +16 more
doaj   +1 more source

The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation [PDF]

, 2023
Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 
Baulch, Janet, Limoli, Charles, Petit, Benoit, Baulch, J.E., Eniko A. Kramár, Kramár, Eniko, Wood, Marcelo, Loo, Billy, Billy W Loo, Vozenin, Marie-Catherine, Janet E. Baulch, Wood, M.A., Charles L. Limoli, Almeida, A., Vozenin, M.C., Ballesteros-Zebadua, P., Veljko Grilj, Ballesteros-Zebadua, Paola, Grilj, V., Almeida, Aymeric, Grilj, Veljko, Kramár, E.A., Aymeric Almeida, Marie-Catherine Vozenin, Petit, B., Benoit Petit, Paola Ballesteros-Zebadua, Limoli, C.L., Loo, B.W., Marcelo A. Wood   +29 more
core   +1 more source

FLASH Radiotherapy: History and Future

Frontiers in Oncology, 2021
The biological effects of radiation dose to organs at risk surrounding tumor target volumes are a major dose-limiting constraint in radiotherapy. This can mean that the tumor cannot be completely destroyed, and the efficacy of radiotherapy will be ...
Binwei Lin, Feng Gao, Yiwei Yang, Dai Wu, Yu Zhang, Gang Feng, Tangzhi Dai, Xiaobo Du   +7 more
doaj   +1 more source

Mechanisms of FLASH effect

Frontiers in Oncology, 2022
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high dose rate (≥ 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects: first, compared with conventional dose rate radiotherapy, FLASH-RT can ...
Binwei Lin, Binwei Lin, Dan Huang, Feng Gao, Yiwei Yang, Dai Wu, Yu Zhang, Gang Feng, Tangzhi Dai, Xiaobo Du   +9 more
doaj   +1 more source

Realization and dosimetric characterization of a mini-beam/flash electron beam

Frontiers in Physics, 2023
The use of the flash effect and mini-beams have demonstrated the ability to spare healthy tissue while maintaining the same effectiveness in controlling tumors. In this study, we present the implementation and comprehensive dosimetric characterization of
Jake Harold Pensavalle, Jake Harold Pensavalle, Jake Harold Pensavalle, Francesco Romano, Francesco Romano, Mariagrazia Celentano, Mariagrazia Celentano, Damiano Del Sarto, Damiano Del Sarto, Giuseppe Felici, Gaia Franciosini, Luigi Masturzo, Luigi Masturzo, Luigi Masturzo, Giuliana Milluzzo, Vincenzo Patera, Yolanda Prezado, Fabio Di Martino, Fabio Di Martino, Fabio Di Martino, Fabio Di Martino   +20 more
doaj   +1 more source

Key changes in the future clinical application of ultra-high dose rate radiotherapy

Frontiers in Oncology, 2023
Ultra-high dose rate radiotherapy (FLASH-RT) is an external beam radiotherapy strategy that uses an extremely high dose rate (≥40 Gy/s). Compared with conventional dose rate radiotherapy (≤0.1 Gy/s), the main advantage of FLASH-RT is that it can reduce ...
Binwei Lin, Mi Fan, Tingting Niu, Yuwen Liang, Haonan Xu, Wenqiang Tang, Xiaobo Du   +6 more
doaj   +1 more source