Results 21 to 30 of about 7,738 (191)

Potential effect of FLASH radiotherapy on testicular damage: a review of current evidence [PDF]

Frontiers in Oncology
Radiotherapy is a major source of ionizing radiation that adversely affects the male reproductive system. FLASH radiotherapy (FLASH-RT), a novel technique delivering ultra-high dose rate (UHDR) radiation, has shown promise in reducing normal tissue ...
Xiaoyu Zhi, Xiaoyu Zhi, Lehui Du, YaNan Han, Weiwei Li, Pei Zhang, Xingdong Guo, Yuan Wang, Na Ma, Xiao Lei, Baolin Qu   +10 more
doaj   +2 more sources

Efficacy of Radiotherapy FLASH-RT: From Treating Lung Cancer to Preventing Pulmonary Fibrosis

Dose-Response
FLASH radiotherapy (FLASH-RT) is a radiotherapy technique that achieves ultra-high dose rates in a fraction of a second. Based on data from experimental animal models, FLASH-RT appears to protect a number of normal tissues from radiation-induced damage ...
Tianyu Yang, Zhiming Xu, Wentao Hu, Zhifei Cao, Yongsheng Zhang   +4 more
doaj   +2 more sources

Establishment and Initial Experience of Clinical FLASH Radiotherapy in Canine Cancer Patients

Frontiers in Oncology, 2021
FLASH radiotherapy has emerged as a treatment technique with great potential to increase the differential effect between normal tissue toxicity and tumor response compared to conventional radiotherapy. To evaluate the feasibility of FLASH radiotherapy in
Elise Konradsson, Maja L. Arendt, Kristine Bastholm Jensen, Betina Børresen, Anders E. Hansen, Sven Bäck, Annemarie T. Kristensen, Per Munck af Rosenschöld, Crister Ceberg, Kristoffer Petersson, Kristoffer Petersson   +10 more
doaj   +3 more sources

Preliminary mechanistic study of mitochondrial function in intestinal protection mediated by high-energy X-ray FLASH radiotherapy [PDF]

Radiation Oncology
Purpose Ultra-high dose rate (UHDR) radiation retains tumor-killing efficacy while mitigating toxicity to normal tissues, holding a promising transformative radiotherapy paradigm.
Xiaofei Hao, Huan Du, Binwei Lin, Decai Wang, Wei Wu, Mingming Tang, Huayan Zhang, Yihan Zhu, Yu Zhang, Yiwei Yang, Xiaobo Du   +10 more
doaj   +2 more sources

Mechanisms underlying FLASH radiotherapy, a novel way to enlarge the differential responses to ionizing radiation between normal and tumor tissues

Radiation Medicine and Protection, 2020
Different from conventional radiotherapy (CONV-RT), FLASH radiotherapy (FLASH-RT) delivers a single high dose at a mean dose rate ≥40 ​Gy/s in milliseconds to achieve similar tumor control to CONV-RT while sparing normal tissues from detrimental injury ...
Guangming Zhou
doaj   +3 more sources

FLASH radiotherapy at a crossroads: a bibliometric perspective on progress and challenges [PDF]

Discover Oncology
Background Flash radiotherapy (FLASH-RT), an emerging modality utilizing ultra-high dose-rate (UHDR) irradiation (typically > 40 Gy/s), has demonstrated a unique capacity to preserve normal tissue integrity while maintaining tumor control efficacy ...
Peng Wang, Yugeng Gao, Can Chen, Xiaoxin Zhao, Yuying Zhang, Taorui Liu, Haoran Jiang, Zhe Wang, Xiang Zhao, Jianjun Li   +9 more
doaj   +2 more sources

Comparable survival in rats with intracranial glioblastoma irradiated with single-fraction conventional radiotherapy or FLASH radiotherapy [PDF]

Frontiers in Oncology, 2023
BackgroundRadiotherapy increases survival in patients with glioblastoma. However, the prescribed dose is limited by unwanted side effects on normal tissue.
Emma Liljedahl, Elise Konradsson, Karin Linderfalk, Emma Gustafsson, Kristoffer Petersson, Kristoffer Petersson, Crister Ceberg, Henrietta Nittby Redebrandt, Henrietta Nittby Redebrandt   +8 more
doaj   +4 more sources

Exploring the role of intestinal microbiota in mitigating acute radiation-induced intestinal injury through high-energy X-ray FLASH radiotherapy via metagenomic analysis [PDF]

Frontiers in Microbiology
ObjectivesThis study preliminarily examines the potential correlation between the gut microbiome and the protective effects of FLASH radiotherapy (FLASH-RT) on intestinal tissue using metagenomic analysis.MethodsCompact single high-energy X-ray source ...
Huan Du, Xiaofei Hao, Binwei Lin, Binwei Lin, Binwei Lin, Yihan Zhu, Yihan Zhu, Yihan Zhu, Yiwei Yang, Mingming Tang, Wei Wu, Decai Wang, Decai Wang, Decai Wang, Bo Lin, Bo Lin, Bo Lin, Yuwen Liang, Wenqiang Tang, Haonan Xu, Jie Li, Jie Li, Jie Li, Feng Gao, Feng Gao, Xiaobo Du, Xiaobo Du, Xiaobo Du   +27 more
doaj   +2 more sources

Consensus statement on the exploration of clinical translation and application of electron ultra‐high dose rate FLASH radiotherapy [PDF]

Precision Radiation Oncology
Ultra‐high dose rate FLASH Radiotherapy (FLASH‐RT) has attracted wide attention because the well‐known FLASH effect and the extremely short irradiation time.
Hui Luo, Chengliang Yang, Jinbo Yue, Hong Ge   +3 more
doaj   +2 more sources

A safety study of ultra‐high dose rate FLASH radiotherapy in the treatment of superficial skin tumors: study protocol of a phase I trial (ChiCTR2400080935) [PDF]

Precision Radiation Oncology
Objective Ultra‐high dose rate FLASH radiotherapy (FLASH‐RT) is emerging as a novel technique to improve the normal tissue tolerance by delivering ultra‐high dose rate radiation several orders of magnitude higher than convention radiotherapy. It has been
Chengliang Yang, Hui Luo, Ma Leijie, Ronghu Mao, Hongchang Lei, Yanping Zhang, Meng Xu, Yiwu Wang, Mingxia Wu, Han Liu, Peng Chen, Hong Ge   +11 more
doaj   +2 more sources