Results 41 to 50 of about 7,738 (191)

Realization and dosimetric characterization of a mini-beam/flash electron beam

Frontiers in Physics, 2023
The use of the flash effect and mini-beams have demonstrated the ability to spare healthy tissue while maintaining the same effectiveness in controlling tumors. In this study, we present the implementation and comprehensive dosimetric characterization of
Jake Harold Pensavalle, Jake Harold Pensavalle, Jake Harold Pensavalle, Francesco Romano, Francesco Romano, Mariagrazia Celentano, Mariagrazia Celentano, Damiano Del Sarto, Damiano Del Sarto, Giuseppe Felici, Gaia Franciosini, Luigi Masturzo, Luigi Masturzo, Luigi Masturzo, Giuliana Milluzzo, Vincenzo Patera, Yolanda Prezado, Fabio Di Martino, Fabio Di Martino, Fabio Di Martino, Fabio Di Martino   +20 more
doaj   +1 more source

Key changes in the future clinical application of ultra-high dose rate radiotherapy

Frontiers in Oncology, 2023
Ultra-high dose rate radiotherapy (FLASH-RT) is an external beam radiotherapy strategy that uses an extremely high dose rate (≥40 Gy/s). Compared with conventional dose rate radiotherapy (≤0.1 Gy/s), the main advantage of FLASH-RT is that it can reduce ...
Binwei Lin, Mi Fan, Tingting Niu, Yuwen Liang, Haonan Xu, Wenqiang Tang, Xiaobo Du   +6 more
doaj   +1 more source

FLASH radiotherapy: A promising new method for radiotherapy.

Oncology letters, 2022
Among the treatments for malignant tumors, radiotherapy is of great significance both as a main treatment and as an adjuvant treatment. Radiation therapy damages cancer cells with ionizing radiation, leading to their death. However, radiation-induced toxicity limits the dose delivered to the tumor, thereby constraining the control effect of ...
Lv, Yinghao, Lv, Yue, Wang, Zhen, Lan, Tian, Feng, Xuping, Chen, Hao, Zhu, Jiang, Ma, Xiao, Du, Jinpeng, Hou, Guimin, Liao, Wenwei, Yuan, Kefei, Wu, Hong   +12 more
openaire   +3 more sources

FLASH Radiotherapy: A FLASHing Idea to Preserve Neurocognitive Function

Brain Tumor Research and Treatment, 2023
FLASH radiotherapy (FLASH RT) is a technique to deliver ultra-high dose rate in a fraction of a second. Evidence from experimental animal models suggest that FLASH RT spares various normal tissues including the lung, gastrointestinal track, and brain from radiation-induced toxicity (a phenomenon known as FLASH effect), which is otherwise commonly ...
Hye-Ju Jo, Taerim Oh, Ye-Rim Lee, Gi-Sue Kang, Hye-Joon Park, G-One Ahn   +5 more
openaire   +2 more sources

FLASH radiotherapy: Newsflash or flash in the pan? [PDF]

Medical Physics, 2019
No abstract. A point / counterpoint article on the merits of ultra-high dose rate radiation therapy.
Maxim, P, Keall, P, Cai, J
openaire   +4 more sources

Long-term anti-tumor effects following both conventional radiotherapy and FLASH in fully immunocompetent animals with glioblastoma

Scientific Reports, 2022
Radiotherapy can induce an immunological response. One limiting factor is side effects on normal tissue. Using FLASH radiotherapy, side effects could possibly be reduced.
Emma Liljedahl, Elise Konradsson, Emma Gustafsson, Karolina Förnvik Jonsson, Jill K. Olofsson, Crister Ceberg, Henrietta Nittby Redebrandt   +6 more
doaj   +1 more source

Proposal of a VHEE Linac for FLASH radiotherapy

Journal of Physics: Conference Series, 2023
Abstract Translation of electron FLASH radiotherapy in clinical practice requires the use of high energy accelerators to treat deep tumours and Very High Electron Energy (VHEE) could represent a valid technique to achieve this goal. In this scenario, a VHEE FLASH linac is under study at the University La Sapienza of Rome (Italy) in ...
Giuliano, L, Bosco, F, Carillo, M, Arcangelis, D De, Ficcadenti, L, Francescone, D, Gregorio, A De, Franciosini, G, Migliorati, M, Mostacci, A, Palumbo, L, Patera, V, Sarti, A, Alesini, D, Behtouei, M, Faillace, L, Gallo, A, Spataro, B, Vannozzi, A, Cirrone, P, Cuttone, G, Torrisi, G, Bisogni, M G, Pensavalle, J H, Martino, F Di, Favaudon, V, Heinrich, S, Patriarca, A   +27 more
openaire   +3 more sources

Technology-driven research for radiotherapy innovation [PDF]

, 2020
Technology has a pivotal role in the continuous development of radiotherapy. The long road toward modern 'high-tech' radiation oncology has been studded with discoveries and technological innovations that resulted from the interaction of various ...
Heijmen, B.J.M. (Ben), Uulke A van der Heide, Heide, U.A. van der, Schwarz, M, Heijmen, B., van der Heide, UA, Schwarz, M., Guckemberger, M., Fiorino, C., Guckemberger, M, Matthias Guckenberger, Ben Heijmen, Heijmen, Ben, Schwarz, M. (Michael), Fiorino, C, Marco Schwarz, Claudio Fiorino   +16 more
core   +1 more source

FLASH radiotherapy treatment planning and models for electron beams

, 2022
: The FLASH effect designates normal tissue sparing at ultra-high dose rate (UHDR, >40 Gy/s) compared to conventional dose rate (∼0.1 Gy/s) irradiation while maintaining tumour control and has the potential to improve the therapeutic ratio ...
Zhang, Rongxiao, Moeckli, R., Rahman, Mahbubur, Böhlen, Till Tobias, Böhlen, T.T., Antonio Trigilio, Till Tobias Böhlen, Franciosini, Gaia, Trigilio, A., Zhang, R., Rahman, M., Moeckli, Raphaël, Gaia Franciosini, Raphaël Moeckli, Rongxiao Zhang, Trigilio, Antonio, Mahbubur Rahman, Franciosini, G.   +17 more
core   +1 more source

FLASH Radiotherapy and the Use of Radiation Dosimeters

Cancers, 2023
Radiotherapy (RT) using ultra-high dose rate (UHDR) radiation, known as FLASH RT, has shown promising results in reducing normal tissue toxicity while maintaining tumor control. However, implementing FLASH RT in clinical settings presents technical challenges, including limited depth penetration and complex treatment planning.
Sarkar Siddique, Harry E. Ruda, James C. L. Chow   +2 more
openaire   +2 more sources