Results 51 to 60 of about 7,738 (191)

FLASH radiotherapy: an emerging approach in radiation therapy

, 2022
FLASH radiotherapy (RT) is a technique involving the delivery of ultra-high dose rate radiation to the target. FLASH-RT has been shown to reduce radiation-induced toxicity in healthy tissues without compromising the anti-cancer effects of treatment ...
Kruszyna-Mochalska, Marta; Electroradiology Department, Poznan University of Medical Sciences, Poznan, Poland; Medical Physics Department, The Greater Poland Cancer Centre, Poznan, Poland, Milecki, Piotr; Electroradiology Department, Poznan University of Medical Sciences, Poznan, Poland; Department of Radiotherapy I, The Greater Poland Cancer Centre, Poznan, Poland, Malicki, Julian; Electroradiology Department, Poznan University of Medical Sciences, Poznan, Poland; Department of Medical Physics, Greater Poland Cancer Centre, Poznan, Poland, Suchorska, Wiktoria Maria; Electroradiology Department, Poznan University of Medical Sciences, Poznan, Poland; Radiobiology Lab. Medical Physics Department, The Greater Poland Cancer Centre, Poznan, Poland, Misiarz, Agnieszka; Centre of High Technology HITEC, Swierk, Otwock, Poland, Otwock, Poland, Pracz, Jacek; Centre of High Technology HITEC, Swierk, Otwock, Poland, Otwock, Poland, Matuszak, Natalia; Electroradiology Department, Poznan University of Medical Sciences, Poznan, Poland; Radiobiology Lab. Medical Physics Department, The Greater Poland Cancer Centre, Poznan, Poland   +6 more
core   +1 more source

FLASH Irradiation Spares Lung Progenitor Cells and Limits the Incidence of Radio-induced Senescence

, 2020
PURPOSE: One of the main limitations to anticancer radiotherapy lies in irreversible damage to healthy tissues located within the radiation field.
Heinrich, Sophie, Leboucher, Sophie, Curras-Alonso, Sandra, Bohec, Mylène, Beddok, Arnaud, Karakurt, Hamza Umut, Verrelle, Pierre, Fouillade, Charles, Vooijs, Marc, Dutreix, Marie, Quelennec, Eddy, Bonnet-Boissinot, Sarah, Favaudon, Vincent, Baulande, Sylvain, Londoño-Vallejo, Arturo, Giuranno, Lorena   +15 more
core   +1 more source

Flash radiotherapy - window of opportunity at an embryonic stage [PDF]

, 2023
No tumor group can be irresponsive to chemotherapy, especially radiotherapy, when applied in sufficient doses. However, in most cases, it is not possible to give effective doses that can destroy the tumor due to side effects and damage that may occur in ...
Uslu, Gonca Hanedan, Yavuz, Aydın
core   +1 more source

Characterization of a diode dosimeter for UHDR FLASH radiotherapy

Medical Physics, 2023
AbstractBackgroundUltra‐high dose rate (UHDR) FLASH beams typically deliver dose at rates of  >40 Gy/sec. Characterization of these beams with respect to dose, mean dose rate, and dose per pulse requires dosimeters which exhibit high temporal resolution and fast readout capabilities.PurposeA diode EDGE Detector with a newly designed electrometer has
Rahman, Mahbubur, Kozelka, Jakub, Hildreth, Jeff, Schonfeld, Andreas, Sloop, Austin M., Ashraf, M. Ramish, Bruza, Petr, Gladstone, David J., Pogue, Brian W., Simon, William E., Zhang, Rongxiao   +10 more
openaire   +3 more sources

FLASH-RT does not affect chromosome translocations and junction structures beyond that of CONV-RT dose-rates [PDF]

, 2023
BACKGROUND AND PURPOSE: The impact of radiotherapy (RT) at ultra high vs conventional dose rate (FLASH vs CONV) on the generation and repair of DNA double strand breaks (DSBs) is an important question that remains to be investigated.
Baulch, Janet, Edlabadkar, A., Limoli, Charles, Barghouth, P.G., Ru, N., Baulch, J.E., Surucu, Murat, Melemenidis, Stavros, Wang, J., Loo, Billy, Viswanathan, Vignesh, Maxim, P.G., Lau, Brianna, Brianna C. Lau, Jinghui Wang, Patrik G. Jorge, Edlabadkar, Anushka, Sadeghi, C., Vozenin, Marie-Catherine, Vozenin, M.C., Montay-Gruel, Pierre, Jorge, Patrik, Maxim, Peter, Vignesh Viswanathan, Amy Yu, Manjappa, Rakesh, Montay-Gruel, P., Ollivier, Jonathan, Anushka Edlabadkar, Sadeghi, Cheyenne, Murat Surucu, Frock, Richard, Marie Le Bouteiller, Lau, B.C., Ollivier, J., Richard Zhang, Ru, Ning, Luis A. Soto, Loo, B.W., Ning Ru, Paul G. Barghouth, Jonathan Ollivier, Billy W. Loo Jr., Skinner, Lawrie, Melemenidis, S., Rakesh Manjappa, Barghouth, Paul, Soto, L.A., Bush, Karl, Yu, Amy, Viswanathan, V., Peter G. Maxim, Le Bouteiller, Marie, Yu, A., Zhang, Richard, Janet E. Baulch, Charles L. Limoli, Wang, Jinghui, Zhang, R., Surucu, M., Richard L. Frock, Soto, Luis, Karl Bush, Frock, R.L., Bush, K., Lawrie Skinner, Le Bouteiller, M., Stavros Melemenidis, Manjappa, R., Pierre Montay-Gruel, Marie-Catherine Vozenin, Skinner, L., Cheyenne Sadeghi, Jorge, P.G., Limoli, C.L.   +74 more
core   +1 more source

Infrared microspectroscopy to elucidate the underlying biomolecular mechanisms of FLASH radiotherapy [PDF]

Altres ajuts: acords transformatius de la UABFLASH-radiotherapy (FLASH-RT) is an emerging modality that uses ultra-high dose rates of radiation to enable curative doses to the tumor while preserving normal tissue.
Petit, Benoît, Froidevaux, Pascal, Prezado, Yolanda, Vozenin, M.C., Montay-Gruel, Pierre, Martínez-Rovira, I., Leavitt, R.J., Juchaux, Marjorie, González Vegas, Roberto, Yousef, Ibraheem, Montay-Gruel, P., González-Vegas, R., Prezado, Y., Martínez-Rovira, Immaculada, Froidevaux, P., Juchaux, M., Petit, B., Leavitt, Ron J., Vozenin, Marie-Catherine, Yousef, I.   +19 more
core   +1 more source

Dosimetry for FLASH Radiotherapy: A review of dosimetric systems

Brazilian Journal of Radiation Sciences
FLASH radiotherapy (FLASH-RT) is a promising approach to cancer treatment, characterized by the delivery of high doses of radiation in a short period of time, within fractions of seconds.
Karoline Feitoza Suzart, Maria da Penha Albuquerque Potiens   +1 more
doaj   +1 more source

FLASH Radiotherapy Enhances the Therapeutic Ratio in an Embryonic In Vivo Model of Pancreatic Carcinoma. [PDF]

ACS Appl Mater Interfaces
Radiotherapy (RT) is a commonly employed treatment in oncological setting. Unfortunately, the therapeutic dose required for tumor control often induces significant side effects in normal tissues, leading to suboptimal outcomes and reduced patient quality
Giannini N, Gonnelli A, Gadducci G, Puccini P, Cavalieri A, Masturzo L, Pensavalle JH, Celentano M, Di Martino F, Di Cocco F, Scatena C, Naccarato AG, Menicagli M, Sarogni P, Frusca V, Cioni D, Aquaro GD, Voliani V, Paiar F.   +18 more
europepmc   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source