Results 71 to 80 of about 7,738 (191)

Smoldering Systemic Mastocytosis Without Detectable KIT Mutation: A Debilitating Course and Therapeutic Challenge

Cancer Nexus, EarlyView.
Graphical abstract illustrating the clinical course and treatment response. ABSTRACT Systemic mastocytosis (SM) is a clonal hematologic neoplasm driven by activating KIT mutations, particularly D816V. Indolent SM typically follows a stable course, progression to higher‐burden subtypes is uncommon.
Homeniuk Anna, Medina Esenbekova, Micheal Bishara, Layo Akinrinwoye, Leila Metellus, Joane Titus   +5 more
wiley   +1 more source

A multi-institutional study to investigate the sparing effect after whole brain electron FLASH in mice: Reproducibility and temporal evolution of functional, electrophysiological, and neurogenic endpoints [PDF]

BACKGROUND AND PURPOSE: Ultra-high dose-rate radiotherapy (FLASH) has been shown to mitigate normal tissue toxicities associated with conventional dose rate radiotherapy (CONV) without compromising tumor killing in preclinical models.
Kramár, Enikö A, Ru, N., Baulch, J.E., Surucu, Murat, Melemenidis, Stavros, Ashraf, M Ramish, Kim, R., Viswanathan, Vignesh, Kim, Rachel, Maxim, P.G., Lau, Brianna, Vozenin, Marie-Catherine, Loo, Billy W, Ramish Ashraf, M., Drayson, Olivia GG, Vozenin, M.C., Montay-Gruel, Pierre, Limoli, Charles L, Katila, N., Manjappa, Rakesh, Wood, Marcelo A, Montay-Gruel, P., Zebadua-Ballasteros, Paola, Baulch, Janet E, Soto, L., Petit, B., Ru, Ning, Loo, B.W., Yu, A.S., Yu, Amu S, Lau, B., Petit, Benoit, Skinner, Lawrie, Zebadua-Ballasteros, P., Melemenidis, S., Maxim, Peter G, Drayson, OGG, Viswanathan, V., Dutt, S., Zhang, Richard, Katila, Nikita, Wood, M.A., Zhang, R., Surucu, M., Soto, Luis, Kramár, E.A., Manjappa, R., Skinner, L., Limoli, C.L., Dutt, Suparna   +49 more
core   +1 more source

Risk of Head and Neck Cancer in Former Smokers by Subsite: A Multicenter Analysis From the INHANCE Consortium

International Journal of Cancer, EarlyView.
Tobacco use and alcohol consumption are primary risk factors for head and neck squamous cell carcinoma, with combined use occurring in three‐quarters of cases. This large international study of former smokers shows that the risk reduction effect of smoking cessation occurs more slowly for laryngeal cancer than for other head and neck cancer subsites ...
Matheus de Abreu, Luiz Paulo Kowalski, Rossana Mendoza López, Christine Barul, Loredana Radoi, Ettore Bidoli, Jerry Polesel, Victor Wunsch‐Filho, Andrew F. Olshan, Jose Zevallos, Eva Negri, Valeria Edefonti, Beata Świątkowska, Dana Mates, Eleonora Fabianova, Jolanta Lissowska, Oxana Shangina, Paul Brennan, Tamas Pandics, Luigino Dal Maso, Hal Morgenstern, Zuo‐Feng Zhang, Karl Kelsey, Michael McClean, Carlo La Vecchia, Werner Garavello, Chu Chen, Stephen M. Schwartz, Heribert Ramroth, Volker Winkler, Gabriella Cadoni, Stefania Boccia, Hermann Brenner, Gypsyamber D'Souza, Neil Gross, Joshua Muscat, Mahsa Abedini, Michele Sassano, Paolo Boffetta, Mia Hashibe, Yuan‐Chin Amy Lee, Maria Paula Curado   +41 more
wiley   +1 more source

Generation of Allogeneic CAR‐T Circumvents Functional Deficits in Patient‐Derived Autologous Product for Glioblastoma

International Journal of Cancer, EarlyView.
Clinical trials of chimeric antigen receptor T‐cell (CAR‐T) therapies in glioblastoma have shown limited clinical benefits. Whether this may be explained by the basal quality of CAR‐T products, which are currently generated using patient, autologous T‐cells, has been little explored.
Sabra K. Salim, Muhammad Vaseem Shaikh, Jeffrey Wei, William T. Maich, Alisha Anand, Oliver Y. Tang, Minomi K. Subapanditha, Zahra Alizada, Yujin Suk, Manoj Singh, Kui Zhai, Aapti Khanna, Benjamin Brakel, Vassil Dimitrov, Zoya Tabunshchyk, Katie Chan, Kevin R. Brown, Parvez Vora, Donald M. O'Rourke, Zev A. Binder, Chitra Venugopal, Jason Moffat, Sheila K. Singh   +22 more
wiley   +1 more source

Mitigating the side effects of conventional radiotherapy: deep examination of the FLASH effect on human healthy bronchial epithelial cell line

Cancer Treatment and Research Communications
Lung cancer is the second leading cause of cancer-related deaths. Treatment based on conventional radiotherapy often results in severe side effects, such as pulmonary fibrosis, a fatal and untreatable condition.
Francesca Del Debbio, Maria Sofia Bertilacchi, Andrea Cavalieri, Giovanni Gadducci, Noemi Giannini, Alessandra Gonnelli, Francesca Cella Zanacchi, Benedetta Noferi, Antonella Catanzariti, Martina De Felice, Chiara Giacomelli, Fabio Di Martino, Claudia Martini, Eleonora Da Pozzo, Fabiola Paiar, Simone Capaccioli   +15 more
doaj   +1 more source

Morphological patterns of buccal bone plate in the maxillary esthetic zone: A cross‐sectional study

Journal of Periodontology, EarlyView.
Abstract Background This cross‐sectional study aimed to characterize buccal bone plate (BBP) morphological patterns in anterior maxillary teeth and to evaluate their association with other phenotypical and local anatomical characteristics. Methods Two examiners conducted a qualitative assessment of BBP morphological patterns using cone‐beam computed ...
Danijel Domic, Diogo Moreira Rodrigues, Emilio Couso‐Queiruga, Eliane Porto Barboza, Mariano Sanz, Christian Ulm, Gustavo Avila‐Ortiz   +6 more
wiley   +1 more source

BART Streams: Real‐Time Reconstruction Using a Modular Framework for Pipeline Processing

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To create modular solutions for interactive real‐time MRI using reconstruction algorithms implemented in BART. Methods A new protocol for streaming of multidimensional arrays is presented and integrated into BART. The new functionality is demonstrated using examples for cardiac interactive real‐time MRI based on radial FLASH, where ...
Philip Schaten, Moritz Blumenthal, Bernhard Rapp, Christina Unterberg‐Buchwald, Martin Uecker   +4 more
wiley   +1 more source

Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis

The Journal of Pathology, EarlyView.
Abstract Acquired lipodystrophy in the dermal white adipose tissue (DWAT) is an early phenotype of skin fibrosis, followed by the accumulation of extracellular matrix (ECM). Lipodystrophy syndromes are estimated to affect 1 in 20,000 people and are associated with metabolic comorbidities.
Suneeti R Madhavan, Piper Moore, Rohan Varshney, Miles Montegut, Qiannan Ma, Kayla Klatt, Reshmi Parameswaran, Elif G Ertugral, Chandrasekhar R Kothapalli, Michael C Rudolph, Radhika P Atit   +10 more
wiley   +1 more source

Main‐chain polyfullerenes: Taking fullerene to the next dimension

Polymer International, EarlyView.
This short review appraises main‐chain polyfullerenes. Their slow development over 30 years has suddenly boomed with a rapid growth due to exciting developments in solar energy. Abstract This mini‐review gives an overview of the development, chemistry, properties and applications of main‐chain polyfullerenes.
Marco Antônio GB Gomes, Orisson Ponce Gomes, Patricia Targon Campana, Didier Bégué, Roger C Hiorns   +4 more
wiley   +1 more source

Endocrine therapy‐induced cancer‐related fatigue in hormone‐dependent malignancies: Mechanisms, impact, and management strategies

Precision Medical Sciences, EarlyView.
Multipathway schematic of endocrine therapy–induced cancer‐related fatigue. Endocrine interventions trigger four interacting mechanisms—neuroendocrine dysregulation, systemic inflammation, energy‐metabolic failure, and psycho‐behavioral amplification—that culminate in the multidimensional CRF phenotype.
Jiajing Jiang, Jun Lu, Sen Qin, Ruzhou Chen, Qiuchen Zhang, Lvqi He, Yubei Li, Jingyao Yan   +7 more
wiley   +1 more source