Results 71 to 80 of about 422,772 (173)

FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy. [PDF]

, 2020
FLASH radiotherapy is the delivery of ultra-high dose rate radiation several orders of magnitude higher than what is currently used in conventional clinical radiotherapy, and has the potential to revolutionize the future of cancer treatment.
Parsons, Jason L, Jason L. Parsons, Hughes, Jonathan R.; id_orcid, Hughes, Jonathan R, Jonathan R. Hughes, Parsons, Jason L.; id_orcid   +5 more
core   +1 more source

Peri‐operative management of patients having day surgery: a consensus statement from the Association of Anaesthetists, British Association for Day Surgery and the Association of Paediatric Anaesthetists, Great Britain and Ireland

Anaesthesia, EarlyView.
Summary Introduction Day surgery is now recognised widely as being a vital component of modern healthcare delivery with overall day surgery rates in the UK now > 85%. Day surgery offers an enhanced experience for patients with reduced risk of postoperative complications (e.g.
Craig R. Bailey, David Bunting, Lindsay Hudman, Shivan Kanani, Kirstin May, Catalina Stendall, Rachel Tibble, Allan Xu, Matthew D. Wiles   +8 more
wiley   +1 more source

FLARE: A design environment for FLASH-based space applications [PDF]

, 2009
Designing a mass-memory device (i.e., a solid-state recorder) is one of the typical issues of mission-critical space system applications. Flash-memories could be used for this goal: a huge number of parameters and trade-offs need to be explored.
Stefano Di Carlo, Caramia, M., Michele Fabiano, Caramia M., Fabiano, Michele, Paolo Prinetto, Prinetto, Paolo Ernesto, Di Carlo, Stefano, Maurizio Caramia   +8 more
core   +1 more source

Factors Influencing the Biological Effects of FLASH Irradiation

Antioxidants
Among the methods for increasing the specificity of tumor radiotherapy, FLASH radiotherapy (FLASH-RT) stands out, having recently entered clinical trials.
Sergey Igorevich Glukhov, Elena Ananievna Kuznetsova, Sergey Vsevolodovich Akulinichev   +2 more
doaj   +1 more source

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

A multi-institutional study to investigate the sparing effect after whole brain electron FLASH in mice: Reproducibility and temporal evolution of functional, electrophysiological, and neurogenic endpoints [PDF]

BACKGROUND AND PURPOSE: Ultra-high dose-rate radiotherapy (FLASH) has been shown to mitigate normal tissue toxicities associated with conventional dose rate radiotherapy (CONV) without compromising tumor killing in preclinical models.
Kramár, Enikö A, Ru, N., Baulch, J.E., Surucu, Murat, Melemenidis, Stavros, Ashraf, M Ramish, Kim, R., Viswanathan, Vignesh, Kim, Rachel, Maxim, P.G., Lau, Brianna, Vozenin, Marie-Catherine, Loo, Billy W, Ramish Ashraf, M., Drayson, Olivia GG, Vozenin, M.C., Montay-Gruel, Pierre, Limoli, Charles L, Katila, N., Manjappa, Rakesh, Wood, Marcelo A, Montay-Gruel, P., Zebadua-Ballasteros, Paola, Baulch, Janet E, Soto, L., Petit, B., Ru, Ning, Loo, B.W., Yu, A.S., Yu, Amu S, Lau, B., Petit, Benoit, Skinner, Lawrie, Zebadua-Ballasteros, P., Melemenidis, S., Maxim, Peter G, Drayson, OGG, Viswanathan, V., Dutt, S., Zhang, Richard, Katila, Nikita, Wood, M.A., Zhang, R., Surucu, M., Soto, Luis, Kramár, E.A., Manjappa, R., Skinner, L., Limoli, C.L., Dutt, Suparna, Maxim, Peter G., Wood, Marcelo A., Yu, Amu S., Baulch, Janet E., Drayson, Olivia G.G., Loo, Billy W., Limoli, Charles L., Ashraf, M. Ramish, Kramár, Enikö A., Loo Jr, Billy W.   +59 more
core   +1 more source

Ultra-high dose rate effect on circulating immune cells: A potential mechanism for FLASH effect?

, 2020
Purpose “FLASH” radiotherapy (RT) is a potential paradigm-changing RT technology with marked tumor killing and normal tissue sparing. However, the mechanism of the FLASH effect is not well understood.
Kong, FMS, Gu, A, Wang, W, Machtay, M, Oleinick, NL, Jin, JY   +5 more
core   +1 more source

Prediction of the treatment effect of FLASH radiotherapy with synchrotron radiation from the Circular Electron–Positron Collider (CEPC)

Journal of Synchrotron Radiation
The Circular Electron–Positron Collider (CEPC) in China can also work as an excellent powerful synchrotron light source, which can generate high-quality synchrotron radiation. This synchrotron radiation has potential advantages in the medical field as it
Junyu Zhang, Xiangyu Wu, Pengyuan Qi, Jike Wang   +3 more
doaj   +1 more source

A20 Inhibits IFN‐γ Signaling in Hepatocellular Carcinoma Cells by Binding to STAT1, Compromising Anti‐Tumor Immunity

Cancer Science, EarlyView.
A20 suppresses IFN‐γ signaling in HCC cells by binding to STAT1 through its ZnF7 domain, thereby reducing CXCL9, CXCL10, and HLA‐ABC expression, ultimately impairing CD8+ T‐cell‐mediated anti‐tumor immunity. ABSTRACT Immune checkpoint blockade (ICB) has demonstrated efficacy in clinical cancer therapy; however, a significant proportion of cancer ...
Yanlei Dong, Jing Yi, Ruoxuan Yang, Yingyue Wang, Zelong Ma, Hong Yuan, Meichen Song, Ying Xiao, Chun Guo, Jianing Wang, Xiaoyan Wang, Faliang Zhu, Lining Zhang, Yuchen Fan, Yongyu Shi   +14 more
wiley   +1 more source

Possible mechanisms and simulation modeling of FLASH radiotherapy

FLASH radiotherapy (FLASH-RT) has great potential to improve patient outcomes. It delivers radiation doses at an ultra-high dose rate (UHDR: ≥ 40 Gy/s) in a single instant or a few pulses.
Fukunaga, Hisanori, Matsuya, Yusuke, Shiraishi, Yuta   +2 more
core   +1 more source