Results 61 to 70 of about 422,772 (173)

Identification of Novel CD52+ Fibroblasts in Nodular Prostatic Hyperplasia

The Prostate, EarlyView.
ABSTRACT Background Benign prostatic hyperplasia (BPH) and lower urinary tract symptoms are strongly associated with chronic prostate inflammation and stromal remodeling, yet the stromal cell programs that emerge during inflammatory, nodular remodeling remain incompletely defined. A Toxoplasma gondii infection model produces persistent inflammation and
Oliver R. Strobel, Hanyu Xia, James P. Ropa, Douglas W. Strand, Travis J. Jerde, Gustavo Arrizabalaga   +5 more
wiley   +1 more source

Context‐Dependent Radioenhancement by Platinum Nanoparticles Under Conventional and Ultra‐High Dose‐Rate “FLASH” Radiotherapy

Small, EarlyView.
Overview of the experimental workflow and main findings of the study investigating Pt‐NPs‐mediated radioenhancement under conventional 134 dose‐rate (CONV) and ultrahigh dose‐rate (UHDR) 9 MeV electron irradiation. Pt‐NP distribution and uptake were characterized in 4T1 spheroids and syngeneic tumor models.
Cathyanne Schott, Foutina Feghali, Marine Gerbé de Thoré, Amina Joudat, Lydia Meziani, Aashini Rajpal, Winchygn Liu, Tudor Manoliu, Farah Savina, Sandrine Lacombe, Eric Deutsch, Julie Colnot, Charlotte Robert, Erika Porcel, Pauline Maury   +14 more
wiley   +1 more source

Exploring the Metabolic Impact of FLASH Radiotherapy. [PDF]

Cancers (Basel)
FLASH radiotherapy (FLASH RT) is an innovative modality in cancer treatment that delivers ultrahigh dose rates (UHDRs), distinguishing it from conventional radiotherapy (CRT).
Geirnaert F, Kerkhove L, Montay-Gruel P, Gevaert T, Dufait I, De Ridder M.   +5 more
europepmc   +3 more sources

FLASH reduces radiation-induced oral mucositis in a mouse model of Fanconi anemia

Clinical and Translational Radiation Oncology
This study demonstrates that FLASH radiotherapy reduces oral mucositis in both wild-type and Fanca -deficient mice. At the cellular level, FLASH attenuated radiation-induced inflammation in the tongue relative to conventional irradiation in both ...
Phoebe Loo, Margaret Pan, Man Zhao, Stavros Melemenidis, Joseph B. Schulz, Dixin Chen, Lucy Whitmore, Sara Richter, Frederick M. Dirbas, Kerriann M. Casey, Edward E. Graves, Michael W. Epperly, Joel Greenberger, Billy W. Loo, Jr., Erinn B. Rankin   +14 more
doaj   +1 more source

Biopolymer‐Based Polyelectrolyte Nanoplatforms for Targeted Photodynamic Therapy of Breast Cancer

VIEW, EarlyView.
Illustration of the synthesis of 5‐aminolevulinic acid loaded chitosan‐sericin polyelectrolyte nanoparticles (CSSN/ALA NPs) using the Flash nanocomplexation (FNC) technique and their potential in photodynamic therapy (PDT) against breast cancer (BC). Abstract Nanomedicine has reshaped healthcare, especially in targeted drug delivery systems (DDSs) and ...
Athira Narayanan, Benedetta di Chiara Stanca, Daniela Pinheiro, Laura Giannotti, Fabrizio Damiano, André Ferreira Moreira, Sónia Miguel, Leonardo Lamanna, Eleonora Stanca, Maria Grazia Raucci, Gianpiero Colangelo, Luisa Siculella, Alessandro Sannino, Paula Coutinho, Christian Demitri   +14 more
wiley   +1 more source

No differences in therapeutic efficacy while sparing healthy tissue for orthotopic glioblastoma patient-derived xenografts in context of proton FLASH

Clinical and Translational Radiation Oncology
Ultra-high dose rate (FLASH-RT) and conventional proton beam radiotherapy to intracranial glioblastoma PDX were compared for tumor control and normal tissue toxicity via DNA and RNA damage response markers.
Taylor L. Schanel, Manoj Kumar, Lauren C. Nassour-Caswell, Sreelakshmi Cherakara, Rhea Pandit, Andee M. Beierle, Joshua C. Anderson, Patrica H. Hicks, Rex Cardan, Anita B. Hjelmeland, Christopher D. Willey   +10 more
doaj   +1 more source

Mechanisms underlying FLASH radiotherapy, a novel way to enlarge the differential responses to ionizing radiation between normal and tumor tissues

Radiation Medicine and Protection, 2020
Different from conventional radiotherapy (CONV-RT), FLASH radiotherapy (FLASH-RT) delivers a single high dose at a mean dose rate ≥40 ​Gy/s in milliseconds to achieve similar tumor control to CONV-RT while sparing normal tissues from detrimental injury ...
Guangming Zhou
doaj   +1 more source

Epiphora: A Structured Diagnostic Approach for the Otolaryngologist

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Introduction Epiphora, or excessive tearing, has historically been predominantly managed by ophthalmologists. However, as there is substantial overlap between ophthalmic and otolaryngologic anatomy and pathology that may contribute to epiphora, patients with this symptom often present to otolaryngologists as well.
Luke M. O'Neil, Sam Kushner‐Lenhoff, Alexandra Van Brummen, Christopher Chambers, Hector Perez, Ashton E. Lehmann, Matthew M. Zhang, Aria Jafari   +7 more
wiley   +1 more source

Comparative Effects of Clinical Pilates Training and Aerobic Exercise on Menopausal Symptoms, Quality of Life, Sleep and Depression: A Randomised Controlled Trial

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To examine the effects of Clinical Pilates (CP) training and aerobic exercise (AE) on menopausal symptoms, depressive symptoms, quality of life (QoL), and sleep quality in postmenopausal women. Design Parallel‐group randomised controlled trial. Setting A Healthy Life Center in Bitlis, Turkey.
Başak Can, Serkan Usgu, Günseli Usgu
wiley   +1 more source

Systemic Therapy Management Strategies for Early‐Stage Breast Cancer in Australia

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Advances in systemic therapy for early‐stage breast cancer in Australia highlight genomic‐guided decisions, subtype‐specific strategies, and emerging targeted and immunotherapies, shaping personalized and de‐escalated treatment approaches. ABSTRACT Breast cancer is the most common cancer among Australian women, with early‐stage disease (Stages I, II ...
Nicholas Zdenkowski, Rachel Dear, Sanjeev Kumar, Hilary Martin, Dhanusha Sabanathan, Stephen J. Luen, Belinda Yeo   +6 more
wiley   +1 more source