Results 81 to 90 of about 422,772 (173)

Unraveling the effects of FLASH and conventional irradiation on retinal pigment epithelial cells: in vitro and in vivo studies

Scientific Reports
The retinal pigment epithelium (RPE) is a fundamental monolayer of pigmented cells that supports visual function, situated between the neural retina and choroidal blood vessels. Radiotherapy is a common treatment for ocular tumors such as uveal melanoma;
Beatrice Di Marco, Gabriele Sansevero, Beatrice D’Orsi, Elisa De Santis, Giulia Salamone, Andrea Cavalieri, Luigi Masturzo, Mariagrazia Celentano, Fabio Di Martino, Simone Capaccioli, Daniele Panetta, Fabiola Paiar, Alessandra Gonnelli, Giovanni Gadducci, Mario Costa, Enrica Strettoi   +15 more
doaj   +1 more source

A Multicellular Coordinated Network Driving Lymphovascular Space Invasion in Endometrioid Endometrial Carcinoma

Cell Proliferation, EarlyView.
Single‐cell and spatial profiling reveal that lymphovascular space invasion in endometrioid endometrial carcinoma is driven by coordinated interactions among metastatic epithelium, fibroblasts, immune cells, and endothelium. This multicellular network promotes matrix remodelling, angiogenesis, and immune evasion, forming a pro‐metastatic niche that ...
Wendi Guo, Tianxiang Liu, Runling Ren, Na Li, Wenwen Zhang, Jingwen Si, Yongjun Piao, Yuanjing Hu   +7 more
wiley   +1 more source

Faster and safer? FLASH ultra-high dose rate in radiotherapy [PDF]

, 2017
Recent results from the Franco-Swiss team of Institute Curie and Centre Hospitalier Universitaire Vaudois demonstrate a remarkable sparing of normal tissue after irradiation at ultra-high dose rate (>40 Gy/s).
Marco Durante, BräUer-Krisch, Elke, Hill, Mark, Durante, Marco, Elke Brauer-Krisch, Mark Hill   +5 more
core   +1 more source

The influence of beam parameters on FLASH effect

Frontiers in Oncology
Ultra-high dose rate radiotherapy (FLASH-RT) is typically defined as an external beam radiotherapy that utilizes a dose rate of 40 Gy/s or higher, compared with conventional dose rate radiotherapy (≤0.1 Gy/s).
Binwei Lin, Binwei Lin, Huan Du, Huan Du, Xiaofei Hao, Xiaofei Hao, Yuwen Liang, Haonan Xu, Wenqiang Tang, Jie Li, Jie Li, Yu Zhang, Yu Zhang, Xiao Bo Du, Xiao Bo Du, Xiao Bo Du   +15 more
doaj   +1 more source

Psychosocial Repercussions and Challenges in Accessing Healthcare for Young Women With Breast Cancer in Brazil: A Qualitative Thematic Analysis

Journal of Clinical Nursing, EarlyView.
ABSTRACT Background Breast cancer in young women is a complex experience that goes beyond biomedical treatment, involves challenges in accessing healthcare, and has psychosocial and relational repercussions. Despite the growing recognition of these dimensions, qualitative studies exploring these experiences in the Brazilian context are still scarce ...
Helena Fiats Ribeiro, Carlos Laranjeira, Sahar Obeid, Feten Fekih‐Romdhane, Camila Wohlenberg Camparoto, Fernando Castilho Pelloso, Lander dos Santos, Maria Dalva de Barros Carvalho, Sandra Marisa Pelloso   +8 more
wiley   +1 more source

Spatially Resolved Metabolomics of Optimal Cutting Temperature (OCT) Compound‐Embedded Tumors

International Journal of Cancer, Volume 159, Issue 12, Page 3038-3048, 15 December 2026.
ABSTRACT Mass spectrometry imaging (MSI) is emerging as a powerful tool for uncovering the distribution of metabolites in the tumor microenvironment and studying tumor metabolism in vivo. To date, MSI of biobanked tissues contextualized by patient data has been limited to peptides, proteins, and glycans—with few examples for metabolites.
Joseph Monaghan, Nicholas Woytowich, Tian Zhao, Kiera Nguyen, Emily Mahony, Julian J. Lum, Kyle D. Duncan   +6 more
wiley   +1 more source

Radiation‐Induced Skin Injury in Cancer Radiotherapy: From Mechanisms to Management

Advanced Oncology, Volume 1, Issue 1, December 2026.
Radiation‐induced skin injuries (RISI) remain a significant challenge faced by cancer patients receiving radiotherapy (RT). This perspective article examines the pathophysiology of RISI and evaluates the currently existing and emerging therapeutic strategies, including stem cell‐derived exosomes and advanced hydrogels.
Zeynep Meral Toutoungi, Nukhet Aykin‐Burns, Jingyi Chen, Younghye Song   +3 more
wiley   +1 more source

Development of Radioiodinated Tetrahydropyrazolopyridine Inhibitors Targeting mIDH

Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 13-14, November-December 2026.
Iodinated tetrahydropyrazolopyridine ligands show enhanced potency and selectivity for mutant IDH1 compared with their fluorinated counterparts and can be efficiently radiolabeled with I‐125, supporting the basis for further evaluation as mIDH1‐targeting radiotheranostic candidates.
Sarandeep Kaur, Sladjana Dukic‐Stefanovic, Lucie Arnaud, Jean‐Michel Chezal, Barbara Wenzel, Rareş‐Petru Moldovan, Klaus Kopka, Aurélie Maisonial‐Besset   +7 more
wiley   +1 more source

Characterization of the Intestinal Metabolic Profiles Following Photon FLASH Irradiation

Dose-Response
Objective Ultra-high dose rate radiotherapy, commonly referred to as FLASH radiotherapy, is a transformative focus in radiotherapeutic research. This study aimed to identify intestinal contents based metabolic biomarkers of photon FLASH. Methods C57BL/6J
Siqian Zhang, Qiliang Peng, Jun Zhang, Zhiming Wang, Xinyang Cheng, Yongsheng Zhang, Zhifei Cao   +6 more
doaj   +1 more source

Dynamic control of carbon‐ion radiation dose distribution amid respiratory motion challenges: A review of prediction research using geant4 and deep learning physics‐constrained models

Journal of Applied Clinical Medical Physics, Volume 27, Issue 11, November 2026.
Abstract Background Carbon ion radiotherapy (CIRT) offers superior dose conformity and biological effectiveness; however, its precision is highly sensitive to respiratory motion, leading to dose uncertainty and interplay effects that compromise treatment accuracy.
Jianhua Ding, Peng Li, Chai Hong Yeong
wiley   +1 more source