Results 81 to 90 of about 7,738 (191)

Design and commissioning of a new synchrotron beamline dedicated to X‐ray footprinting mass spectrometry

Journal of Synchrotron Radiation, EarlyView.
A dedicated beamline at the Advanced Light Source synchrotron has been opened and commissioned for X‐ray footprinting mass spectrometry.The structural biology method of X‐ray footprinting mass spectrometry (XFMS) is available at two national synchrotron beamlines in the USA: one at the Advanced Light Source (ALS) on the West Coast and the other at the ...
Sayan Gupta, Brandon Russell, Line G. Kristensen, Jared de Chant, Anthony Lu, Lieselotte Obst-Huebl, Behzad Rad, James Tyler, Simruthi Subramanian, Savannah Kidd, Sathi Paul, Yan Chen, Christopher J. Petzold, Darren N. Kahan, Shawn M. Costello, Kei Nakamura, Jamie L. Inman, Alastair A. MacDowell, Adrian Spucces, Corie Y. Ralston   +19 more
wiley   +1 more source

No differences in therapeutic efficacy while sparing healthy tissue for orthotopic glioblastoma patient-derived xenografts in context of proton FLASH

Clinical and Translational Radiation Oncology
Ultra-high dose rate (FLASH-RT) and conventional proton beam radiotherapy to intracranial glioblastoma PDX were compared for tumor control and normal tissue toxicity via DNA and RNA damage response markers.
Taylor L. Schanel, Manoj Kumar, Lauren C. Nassour-Caswell, Sreelakshmi Cherakara, Rhea Pandit, Andee M. Beierle, Joshua C. Anderson, Patrica H. Hicks, Rex Cardan, Anita B. Hjelmeland, Christopher D. Willey   +10 more
doaj   +1 more source

Effect of oxygen and nanoparticles on human skin and colon cells exposed to synchrotron‐based X‐ray FLASH beams

Journal of Synchrotron Radiation, EarlyView.
Most cancer patients will be treated by radiotherapy, and recent findings suggest that delivering radiation at `FLASH' ultra‐high dose rates reduces damage to healthy tissues while still damaging the tumour. This project experimentally validates the reduced healthy tissue damage of FLASH radiotherapy on cells using synchrotron‐based beams, which will ...
Moshi Geso, Matthew Cameron, Tom Ffrench, Helen Forrester, Rod Lynch, Masao Nakayama, William Patterson, Wan Nordiana Rahman, Duncan Butler, Terrence J. Piva   +9 more
wiley   +1 more source

Comparative Effects of Clinical Pilates Training and Aerobic Exercise on Menopausal Symptoms, Quality of Life, Sleep and Depression: A Randomised Controlled Trial

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To examine the effects of Clinical Pilates (CP) training and aerobic exercise (AE) on menopausal symptoms, depressive symptoms, quality of life (QoL), and sleep quality in postmenopausal women. Design Parallel‐group randomised controlled trial. Setting A Healthy Life Center in Bitlis, Turkey.
Başak Can, Serkan Usgu, Günseli Usgu
wiley   +1 more source

DataSheet1_Architecture, flexibility and performance of a special electron linac dedicated to Flash radiotherapy research: electronFlash with a triode gun of the centro pisano flash radiotherapy (CPFR).docx

, 2023
The FLASH effect is a radiobiological phenomenon that has garnered considerable interest in the clinical field. Pre-clinical experimental studies have highlighted its potential to reduce side effects on healthy tissues while maintaining isoeffectiveness ...
M. Marinelli (4927774), D. Del Sarto (17398921), A. Douralis (17398933), G. Milluzzo (17398942), M. Marrale (17398936), J. H. Pensavalle (17398951), L. Raffaele (17398954), S. Capaccioli (1524481), F. Romano (9905838), F. Paiar (17398948), M. Celentano (17398927), A. Subiel (17398957), G. Bass (17398924), D. Coves (17398930), G. Felici (17398966), G. Verona Rinati (17398963), E. Touzain (17398960), M. Montefiori (17398945), F. Di Martino (17398918), L. Masturzo (17398939)   +19 more
core   +1 more source

Systemic Therapy Management Strategies for Early‐Stage Breast Cancer in Australia

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Advances in systemic therapy for early‐stage breast cancer in Australia highlight genomic‐guided decisions, subtype‐specific strategies, and emerging targeted and immunotherapies, shaping personalized and de‐escalated treatment approaches. ABSTRACT Breast cancer is the most common cancer among Australian women, with early‐stage disease (Stages I, II ...
Nicholas Zdenkowski, Rachel Dear, Sanjeev Kumar, Hilary Martin, Dhanusha Sabanathan, Stephen J. Luen, Belinda Yeo   +6 more
wiley   +1 more source

Prediction of the treatment effect of FLASH radiotherapy with synchrotron radiation from the Circular Electron–Positron Collider (CEPC)

Journal of Synchrotron Radiation
The Circular Electron–Positron Collider (CEPC) in China can also work as an excellent powerful synchrotron light source, which can generate high-quality synchrotron radiation. This synchrotron radiation has potential advantages in the medical field as it
Junyu Zhang, Xiangyu Wu, Pengyuan Qi, Jike Wang   +3 more
doaj   +1 more source

FLASH Radiotherapy

RADIOISOTOPES, 2021
Iwata, Hiromitsu, Shibamoto, Yuta
openaire   +2 more sources

ITGA5 as a Dual Regulator of Epithelial‐Mesenchymal Transition and Epithelial Cell Anoikis Resistance: Functional Validation and Drug Prediction

Cell Proliferation, EarlyView.
Proteomics and functional validation reveal ITGA5 as a dual promoter of epithelial‐mesenchymal transition and anoikis resistance in human bronchial epithelium: targeting ITGA5 represents a novel therapeutic strategy for asthma airway remodelling. ABSTRACT Airway remodelling is a major contributor to persistent airflow limitation and irreversible lung ...
Ting Wang, Ling Rao, Xiaofang Li, Miaofen Zhang, Huiting Huang, Zhiyan Luo, Gang Liao, Yong Jiang, Shaofeng Zhan, Qiong Liu, Xiufang Huang   +10 more
wiley   +1 more source

Decrease in dose per fraction impairs the FLASH sparing effect in murine intestine model

FLASH radiotherapy (FLASH) can ease radiation-induced normal tissue toxicities; however, its benefit in clinically relevant fractionation protocols remains insufficiently explored.
Geyer, R, Devanand, P, Bailat, C, Sesink, A, Böhlen, T T, Soutter, L, Moeckli, R, Herrera, F G, Grilj, V   +8 more
core   +1 more source