Results 91 to 100 of about 7,738 (191)

Unraveling the effects of FLASH and conventional irradiation on retinal pigment epithelial cells: in vitro and in vivo studies

Scientific Reports
The retinal pigment epithelium (RPE) is a fundamental monolayer of pigmented cells that supports visual function, situated between the neural retina and choroidal blood vessels. Radiotherapy is a common treatment for ocular tumors such as uveal melanoma;
Beatrice Di Marco, Gabriele Sansevero, Beatrice D’Orsi, Elisa De Santis, Giulia Salamone, Andrea Cavalieri, Luigi Masturzo, Mariagrazia Celentano, Fabio Di Martino, Simone Capaccioli, Daniele Panetta, Fabiola Paiar, Alessandra Gonnelli, Giovanni Gadducci, Mario Costa, Enrica Strettoi   +15 more
doaj   +1 more source

Factors Influencing the Biological Effects of FLASH Irradiation

Antioxidants
Among the methods for increasing the specificity of tumor radiotherapy, FLASH radiotherapy (FLASH-RT) stands out, having recently entered clinical trials.
Sergey Igorevich Glukhov, Elena Ananievna Kuznetsova, Sergey Vsevolodovich Akulinichev   +2 more
doaj   +1 more source

Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism

Cell Proliferation, EarlyView.
Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang, Yuan‐Tao Qiu, Jing‐Yue Cao, Yi‐Feng Huang, Ye‐Lin Lan, Yu‐Li Zhao, Fu Wu, Chen‐Long Wang, Guo‐Run Tang, Jing‐Yun Ji, Zhang Zhang, Guan‐Zheng Luo   +11 more
wiley   +1 more source

The influence of beam parameters on FLASH effect

Frontiers in Oncology
Ultra-high dose rate radiotherapy (FLASH-RT) is typically defined as an external beam radiotherapy that utilizes a dose rate of 40 Gy/s or higher, compared with conventional dose rate radiotherapy (≤0.1 Gy/s).
Binwei Lin, Binwei Lin, Huan Du, Huan Du, Xiaofei Hao, Xiaofei Hao, Yuwen Liang, Haonan Xu, Wenqiang Tang, Jie Li, Jie Li, Yu Zhang, Yu Zhang, Xiao Bo Du, Xiao Bo Du, Xiao Bo Du   +15 more
doaj   +1 more source

Suppression of Retinal Neovascularisation by Tetrahedral Framework Nucleic Acids‐Resveratrol Via Dual Anti‐Angiogenesis and Anti‐Inflammation

Cell Proliferation, EarlyView.
Resveratrol‐loaded tetrahedral framework nucleic acids (tFNAs‐RSV) enable concurrent anti‐angiogenic and anti‐inflammatory therapy, enhancing ocular delivery and bioactivity. In hypoxia‐induced retinal neovascularisation, tFNAs‐RSV reduce neovascular lesions, vascular leakage and inflammatory infiltration by suppressing HIF‐1, p38 MAPK and NF‐κB p65 ...
Yili Jin, Tao Cai, Junyang Huang, Li Chen, Yi Lin, Jingying Liu, You Wang, Xiaoyan Ding   +7 more
wiley   +1 more source

Design of synchrotron for proton FLASH radiotherapy

Journal of Physics: Conference Series
Abstract Proton FLASH, which combines the advantages of a better spatial dose distribution of protons with the unique temporal effect of FLASH radiotherapy, is currently a hot topic of international research. In this study, a series of innovative methods are proposed to manipulate the beam with the longitudinal dynamics and to extract ...
Zheng,Shu-xin, Xiong,Yang, Yao,Hongjuan, Wang,Xuewu, Liu,Xiaoyu, Li,Yan, Wang,Zejiang, Xing,Qingzi   +7 more
openaire   +1 more source

A Multicellular Coordinated Network Driving Lymphovascular Space Invasion in Endometrioid Endometrial Carcinoma

Cell Proliferation, EarlyView.
Single‐cell and spatial profiling reveal that lymphovascular space invasion in endometrioid endometrial carcinoma is driven by coordinated interactions among metastatic epithelium, fibroblasts, immune cells, and endothelium. This multicellular network promotes matrix remodelling, angiogenesis, and immune evasion, forming a pro‐metastatic niche that ...
Wendi Guo, Tianxiang Liu, Runling Ren, Na Li, Wenwen Zhang, Jingwen Si, Yongjun Piao, Yuanjing Hu   +7 more
wiley   +1 more source

Characterization of the Intestinal Metabolic Profiles Following Photon FLASH Irradiation

Dose-Response
Objective Ultra-high dose rate radiotherapy, commonly referred to as FLASH radiotherapy, is a transformative focus in radiotherapeutic research. This study aimed to identify intestinal contents based metabolic biomarkers of photon FLASH. Methods C57BL/6J
Siqian Zhang, Qiliang Peng, Jun Zhang, Zhiming Wang, Xinyang Cheng, Yongsheng Zhang, Zhifei Cao   +6 more
doaj   +1 more source

Identifying Out‐of‐the‐Box Virtual Reality Applications With Geriatric Applicability and Value

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Virtual reality (VR) has the potential to improve the quality of life for older adults. Most studies use proprietary VR programs, specifically designed for one goal, which vastly limits the generalizability and use by the older adult population.
Alexandra Petrakos, Diana Medved, Amber Winder, Leo L. Nelson, Lexi N. Lindquist, Lee A. Lindquist   +5 more
wiley   +1 more source

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Central role of pericytes across major pulmonary diseases. Conceptual wheel diagram illustrating the central role of lung pericytes across diverse pulmonary disease states. A pericyte positioned at the center expresses canonical markers, including PDGFRβ, CD146, and NG2, and connects radially to five major disease contexts.
Stuti Agarwal, Anuradha Bankar, Vinicio A. de Jesus Perez   +2 more
wiley   +1 more source