Results 31 to 40 of about 7,738 (191)

The oxygen puzzle in FLASH radiotherapy: A comprehensive review and experimental outlook [PDF]

Clinical and Translational Radiation Oncology
FLASH radiotherapy is attracting increasing interest because it maintains tumor control while inflicting less damage to normal tissues compared to conventional radiotherapy.
Andrea Scarmelotto, Victor Delprat, Carine Michiels, Stéphane Lucas, Anne-Catherine Heuskin   +4 more
doaj   +2 more sources

Mechanisms, challenges and opportunities for FLASH radiotherapy in cancer [PDF]

Nature Reviews Cancer
Marie-Catherine Vozenin, Pierre Montay-Gruel, Charles L Limoli   +2 more
exaly   +2 more sources

Non-conventional Ultra-High Dose Rate (FLASH) Microbeam Radiotherapy Provides Superior Normal Tissue Sparing in Rat Lung Compared to Non-conventional Ultra-High Dose Rate (FLASH) Radiotherapy [PDF]

, 2021
Conventional radiotherapy is a widely used non-invasive form of treatment for many types of cancer. However, due to a low threshold in the lung for radiation-induced normal tissue damage, it is of less utility in treating lung cancer.
Bravin, A., Wright, M.D., Wright, Michael D., Requardt, Herwig, Hlushchuk, R., Romanelli, Pantaleo, Romanelli, P., Bartzsch, S., Bartzsch, Stefan, Le Duc, G., Djonov, Valentin, Laissue, Jean-Albert, Requardt, H., Bravin, Alberto, Hlushchuk, Ruslan, Brauer-Krisch, Elke, Bräuer-Krisch, E., Le Duc, Geraldine, Djonov, V., Laissue, J.A.   +19 more
core   +1 more source

New insights on clinical perspectives of FLASH radiotherapy: from low- to very high electron energy

Frontiers in Oncology, 2023
Radiotherapy (RT) is performed in approximately 75% of patients with cancer, and its efficacy is often hampered by the low tolerance of the surrounding normal tissues.
Stefano Ursino, Stefano Ursino, Stefano Ursino, Giovanni Gadducci, Giovanni Gadducci, Noemi Giannini, Noemi Giannini, Alessandra Gonnelli, Alessandra Gonnelli, Taiushia Fuentes, Taiushia Fuentes, Fabio Di Martino, Fabio Di Martino, Fabiola Paiar, Fabiola Paiar, Fabiola Paiar   +15 more
doaj   +1 more source

Conditional sparing in FLASH radiotherapy: Conformal dosimetry and ALARA remain essential. [PDF]

J Appl Clin Med Phys
Abstract FLASH radiotherapy shows promise in reducing normal tissue toxicity while maintaining tumor control. However, preclinical and early clinical evidence reveal biological and technical uncertainties. We review preclinical and veterinary studies, highlight unexpected toxicities, and argue that the fundamental principles of precision and safety in ...
Chang CC, Ma Y, Kang M, Paliwal B, Morris Z, Durkee B, Cheng C.   +6 more
europepmc   +2 more sources

The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation [PDF]

, 2023
Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 
Baulch, Janet, Limoli, Charles, Petit, Benoit, Baulch, J.E., Eniko A. Kramár, Kramár, Eniko, Wood, Marcelo, Loo, Billy, Billy W Loo, Vozenin, Marie-Catherine, Janet E. Baulch, Wood, M.A., Charles L. Limoli, Almeida, A., Vozenin, M.C., Ballesteros-Zebadua, P., Veljko Grilj, Ballesteros-Zebadua, Paola, Grilj, V., Almeida, Aymeric, Grilj, Veljko, Kramár, E.A., Aymeric Almeida, Marie-Catherine Vozenin, Petit, B., Benoit Petit, Paola Ballesteros-Zebadua, Limoli, C.L., Loo, B.W., Marcelo A. Wood   +29 more
core   +1 more source

Mechanisms of FLASH effect

Frontiers in Oncology, 2022
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high dose rate (≥ 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects: first, compared with conventional dose rate radiotherapy, FLASH-RT can ...
Binwei Lin, Binwei Lin, Dan Huang, Feng Gao, Yiwei Yang, Dai Wu, Yu Zhang, Gang Feng, Tangzhi Dai, Xiaobo Du   +9 more
doaj   +1 more source

An insight into hypothesized biological mechanisms contributing to the Flash effect

Frontiers in Physics, 2023
In recent years, FLASH radiotherapy (FLASH RT) has gained attention in preclinical studies as a potential advancement in cancer treatment. The great advantage of FLASH RT is the ultra-fast, high doses delivery that have a similar or greater effect on ...
Francesca Del Debbio, Maria Sofia Bertilacchi, Alessandra Gonnelli, Alessandra Gonnelli, Eleonora Da Pozzo, Eleonora Da Pozzo, Eleonora Da Pozzo, Valentina Tozzini, Valentina Tozzini, Claudia Martini, Claudia Martini, Claudia Martini, Simone Capaccioli, Simone Capaccioli, Simone Capaccioli, Barbara Costa, Barbara Costa   +16 more
doaj   +1 more source

Towards photon FLASH radiotherapy

FLASH radiotherapy is a promising treatment modality that employs ultra-high dose rates (>=40 Gy/s) and short delivery times (<1 s) to achieve enhanced normal tissue sparing while maintaining equivalent tumour control compared to conventional radiotherapy.
Taylor, Edward Rupert James Finbow
openaire   +3 more sources

FLASH radiotherapy with carbon ion beams [PDF]

Medical Physics, 2021
AbstractFLASH radiotherapy is considered a new potential breakthrough in cancer treatment. Ultra‐high dose rates (>40 Gy/s) have been shown to reduce toxicity in the normal tissue without compromising tumor control, resulting in a widened therapeutic window.
Weber U. A., Scifoni E., Durante M.
openaire   +6 more sources