Results 11 to 20 of about 7,738 (191)

The FLASH effect—an evaluation of preclinical studies of ultra-high dose rate radiotherapy

Frontiers in Oncology
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy approach based on the use of ultra-high dose radiation to treat malignant cells. Although tumours can be reduced or eradicated using radiotherapy, toxicities induced by radiation can compromise ...
Josie May McGarrigle, Kenneth Richard Long, Kenneth Richard Long, Yolanda Prezado, Yolanda Prezado   +4 more
doaj   +4 more sources

Radiobiology and treatment plan progress of FLASH radiotherapy

Fushe yanjiu yu fushe gongyi xuebao, 2023
FLASH radiotherapy is a novel method that has the potential to improve the therapeutic gain ratio to a new level. FLASH radiotherapy technology is mainly characterized by irradiation at ultra-high dose rate, which can reduce radiation-induced injury to ...
WU Xun, LIU Ruifeng, ZHANG Qiuning, WANG Xiaohu   +3 more
doaj   +2 more sources

Radiobiological Aspects of FLASH Radiotherapy

Biomolecules, 2022
Radiotherapy (RT) is one of the primary treatment modalities for cancer patients. The clinical use of RT requires a balance to be struck between tumor effect and the risk of toxicity. Sparing normal tissue is the cornerstone of reducing toxicity. Advances in physical targeting and dose-shaping technology have helped to achieve this.
Eline Hageman, Pei-Pei Che, Max Dahele, Ben J. Slotman, Peter Sminia   +4 more
openaire   +5 more sources

FLASH Radiotherapy: a Promising Direction in the Fight Against Cancer

Вестник рентгенологии и радиологии, 2021
At the present stage of scientific and technological progress, high-dose radiotherapy has become a common way to combat severe cancers. However, this treatment option is limited by normal tissues radiosensitivity.
А. V. Каrtashev, Т. N. Bochkareva, А. S. Anokhina   +2 more
doaj   +3 more sources

Democratizing FLASH Radiotherapy. [PDF]

Semin Radiat Oncol
FLASH radiotherapy (RT) is emerging as a potentially revolutionary advancement in cancer treatment, offering the potential to deliver RT at ultra-high dose rates (>40 Gy/s) while significantly reducing damage to healthy tissues. Democratizing FLASH RT by making this cutting-edge approach more accessible and affordable for healthcare systems worldwide ...
Moreau M, Mao S, Ngwa U, Yasmin-Karim S, China D, Hooshangnejad H, Sforza D, Ding K, Li H, Rezaee M, Narang AK, Ngwa W.   +11 more
europepmc   +3 more sources

Electron FLASH radiotherapy in vivo studies. A systematic review [PDF]

Frontiers in Oncology
FLASH-radiotherapy delivers a radiation beam a thousand times faster compared to conventional radiotherapy, reducing radiation damage in healthy tissues with an equivalent tumor response.
Noemi Giannini, Noemi Giannini, Giovanni Gadducci, Giovanni Gadducci, Taiusha Fuentes, Taiusha Fuentes, Alessandra Gonnelli, Alessandra Gonnelli, Fabio Di Martino, Fabio Di Martino, Fabio Di Martino, Paola Puccini, Monica Naso, Francesco Pasqualetti, Simone Capaccioli, Simone Capaccioli, Fabiola Paiar, Fabiola Paiar, Fabiola Paiar   +18 more
doaj   +3 more sources

Phenomenological insights into the FLASH radiotherapy-induced abscopal effect [PDF]

Frontiers in Oncology
BackgroundThe abscopal effect suggests that the impact of radiotherapy extends beyond the direct tumor local regression, due to activation of the immune response. Its effectiveness may vary depending on whether high- or low-radiation doses are used.
Paolo Castorina, Paolo Castorina, Paolo Castorina, Gianluca Ferini, Gianluca Ferini, Francesco Romano   +5 more
doaj   +2 more sources

Architecture, flexibility and performance of a special electron linac dedicated to Flash radiotherapy research: electronFlash with a triode gun of the centro pisano flash radiotherapy (CPFR) [PDF]

Frontiers in Physics, 2023
The FLASH effect is a radiobiological phenomenon that has garnered considerable interest in the clinical field. Pre-clinical experimental studies have highlighted its potential to reduce side effects on healthy tissues while maintaining isoeffectiveness ...
F. Di Martino, F. Di Martino, F. Di Martino, D. Del Sarto, D. Del Sarto, D. Del Sarto, G. Bass, S. Capaccioli, S. Capaccioli, M. Celentano, M. Celentano, D. Coves, A. Douralis, M. Marinelli, M. Marrale, M. Marrale, M. Marrale, L. Masturzo, L. Masturzo, G. Milluzzo, M. Montefiori, M. Montefiori, F. Paiar, F. Paiar, J. H. Pensavalle, J. H. Pensavalle, L. Raffaele, F. Romano, A. Subiel, E. Touzain, G. Verona Rinati, G. Felici   +31 more
doaj   +5 more sources

The Biophysics of Flash Radiotherapy: Tools for Measuring Tumor and Normal Tissues Microenvironment [PDF]

Antioxidants
Ultra-high dose rate radiotherapy known as Flash radiotherapy (FLASH-RT) offers tremendous opportunities to improve the therapeutic ratio of radiotherapy by sparing the normal tissue while maintaining similar tumoricidal efficacy. However, the underlying
Islam G. Ali, Issam El Naqa
doaj   +2 more sources

Absolute dosimetry for FLASH proton pencil beam scanning radiotherapy [PDF]

Scientific Reports, 2023
A paradigm shift is occurring in clinical oncology exploiting the recent discovery that short pulses of ultra-high dose rate (UHDR) radiation—FLASH radiotherapy—can significantly spare healthy tissues whilst still being at least as effective in curing ...
Ana Lourenço, Anna Subiel, Nigel Lee, Sam Flynn, John Cotterill, David Shipley, Francesco Romano, Joe Speth, Eunsin Lee, Yongbin Zhang, Zhiyan Xiao, Anthony Mascia, Richard A. Amos, Hugo Palmans, Russell Thomas   +14 more
doaj   +2 more sources