Results 31 to 40 of about 381 (150)

SAFEST: a compact C-band linear accelerator for VHEE-FLASH radiotherapy [PDF]

, 2023
FLASH Radiotherapy is a revolutionary new technique in the cancer cure. Several pre-clinical studies have demonstrated that treatment with electron radiation delivered with mean dose rates above 100Gy/s, an ultra-high instantaneous dose rate > 106Gy/s, and total irradiation time < 100ms, significantly decreases the toxicity in the healthy tissue while ...
L. Palumbo, A. Sarti, A. Mostacci, A. De Gregorio, D. De Arcangelis, D. Francescone, E. Chiadroni, G. Franciosini, L. Ficcadenti, M. Magi, M. Carillo, V. Patera, A. Gallo, A. Vannozzi, B. Spataro, D. Alesini, F. Cardelli, F. Romano, G. Cuttone, G. Mauro, G. Franzini, G. Milluzzo, G. Cirrone, G. Torrisi, L. Piersanti, L. Giuliano, L. Faillace, R. Di Raddo, F. Bosco, F. Di Martino, M. Bisogni, G. Silvi, M. Migliorati, G. Sorbello   +33 more
openaire   +3 more sources

Playing Hard with Si: Challenges and Opportunities for New Materials in Radiation Therapy Dosimetry. [PDF]

Adv Mater
Silicon has been a cornerstone material of radiation therapy dosimetry for many decades, providing somewhat unchallenged performance. However, there are caveats to its use, requiring complex designs and, often, correction factors to provide accurate measurements.
Cayley J, Filipev I, Davis JA, de Rover V, Cutajar D, Li E, Oborn BM, Petasecca M, Rosenfeld A, Lerch MLF.   +9 more
europepmc   +2 more sources

Standard requirements for clinical very high energy electron and ultra high dose rate medical devices [PDF]

Frontiers in Physics
Very High-Energy Electrons (VHEE) present a promising innovation in radiation therapy (RT), particularly for the treatment of deep-seated tumors using Ultra High Dose Rate (UHDR) within the framework of FLASH-RT.
J. H. Pensavalle, F. Di Martino, F. Di Martino, F. Di Martino, A. Cavalieri, M. Celentano, M. Celentano, A. De Gregorio, A. De Gregorio, M. Di Francesco, G. Franciosini, G. Franciosini, L. Galluzzo, L. Masturzo, L. Masturzo, G. Milluzzo, P. Montay-Gruel, P. Montay-Gruel, F. Paiar, F. Paiar, F. Paiar, M. Pantaleoni, V. Patera, V. Patera, S. Pioli, P. Poortmans, P. Poortmans, F. Romano, F. Romano, A. Sarti, A. Sarti, A. Subiel, A. Subiel, A. Vannozzi, G. Felici   +34 more
doaj   +7 more sources

Characterization of Titanium Effects on Very High Energy Electron (VHEE) Beams [PDF]

E3S Web of Conferences
Very High Energy Electron (VHEE) therapy is gaining attention as an innovative approach for treating deep-seated tumors, combining favorable dose deposition, sharp lateral penumbra, and compatibility with ultra-high dose rate (FLASH) delivery. A critical
Essaidi El Mehdi, Krim Mustapha, Didi Abdessamad, Tantaoui Meriem, Kaanouch Othmane   +4 more
doaj   +2 more sources

First theoretical determination of relative biological effectiveness of very high energy electrons [PDF]

Scientific Reports, 2021
Very high energy electrons (VHEEs, E > 70 MeV) present promising clinical advantages over conventional beams due to their increased range, improved penumbra and relative insensitivity to tissue heterogeneities.
Rachel Delorme, Thongchai A. M. Masilela, Camille Etoh, François Smekens, Yolanda Prezado   +4 more
doaj   +2 more sources

Extending deterministic transport capabilities for very-high and ultra-high energy electron beams [PDF]

Scientific Reports
Focused Very-High Energy Electron (VHEE, 50–300 MeV) and Ultra-High Energy Electron (UHEE, > 300 MeV) beams can accurately target both large and deeply seated human tumors with high sparing properties, while avoiding the spatial requirements and cost of ...
Ahmed Naceur, Charles Bienvenue, Paul Romano, Cornelia Chilian, Jean-François Carrier   +4 more
doaj   +2 more sources

Design, construction, and test of compact, distributed-charge, X-band accelerator systems that enable image-guided, VHEE FLASH radiotherapy

Frontiers in Physics
The design and optimization of laser-Compton x-ray systems based on compact distributed charge accelerator structures can enable micron-scale imaging of disease and the concomitant production of beams of Very High Energy Electrons (VHEEs) capable of ...
Christopher P J Barty, Frédéric V Hartemann, Luis E Zapata   +2 more
exaly   +3 more sources

Optics Design and Beam Dynamics simulation for a VHEE Radiobiology beam line at PRAE accelerator [PDF]

Journal of Physics: Conference Series, 2019
Abstract The Platform for Research and Applications with Electrons (PRAE) is a multidisciplinary R&D facility gathering subatomic physics, instrumentation, radiobiology and clinical research around a high-performance electron accelerator with beam energies up to 70 MeV.
Faus-Golfe, Angeles, Bai, Bowen, Delorme, Rachel, Dosanjh, Manjit, Duchesne, Patricia, Favaudon, Vincent, Fouillade, Charles, Han, Yanliang, Poortmans, Philip, Pouzoulet, Frederic, Prezado, Yolanda, Vallerand, Cynthia   +11 more
openaire   +2 more sources

Active dosimetry for VHEE FLASH radiotherapy using beam profile monitors and charge measurements

Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
The discovery of the FLASH effect has revealed a high potential for treating cancer more efficiently by sparing healthy tissue. The surge in related medical research activities over the last couple of years has triggered a demand for technology with the capability of generating and measuring ionizing radiation at ultra-high dose-rates (UHDR).
Wilfrid Farabolini, Vilde Rieker, Roberto Corsini   +2 more
exaly   +3 more sources

Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage

Scientific Reports, 2021
This paper presents the first plasmid DNA irradiations carried out with Very High Energy Electrons (VHEE) over 100–200 MeV at the CLEAR user facility at CERN to determine the Relative Biological Effectiveness (RBE) of VHEE.
K. L. Small, N. T. Henthorn, D. Angal-Kalinin, A. L. Chadwick, E. Santina, A. Aitkenhead, K. J. Kirkby, R. J. Smith, M. Surman, J. Jones, W. Farabolini, R. Corsini, D. Gamba, A. Gilardi, M. J. Merchant, R. M. Jones   +15 more
doaj   +1 more source