Results 31 to 40 of about 480 (154)

Design, Construction, and Test of Compact, Distributed-Charge, X-Band Accelerator Systems That Enable Image-Guided, VHEE FLASH Radiotherapy

Frontiers in Physics
The design and optimization of laser-Compton x-ray systems based on compact distributed charge accelerator structures can enable micron-scale imaging of disease and the concomitant production of beams of Very High Energy Electrons (VHEEs) capable of ...
Christopher P. J. Barty, Christopher P. J. Barty, Christopher P. J. Barty, J. Martin Algots, Alexander J. Amador, James C. R. Barty, Shawn M. Betts, Marcelo A. Castañeda, Matthew M. Chu, Michael E. Daley, Ricardo A. De Luna Lopez, Derek A. Diviak, Haytham H. Effarah, Haytham H. Effarah, Haytham H. Effarah, Roberto Feliciano, Adan Garcia, Keith J. Grabiel, Alex S. Griffin, Frederic V. Hartemann, Leslie Heid, Leslie Heid, Yoonwoo Hwang, Gennady Imeshev, Michael Jentschel, Christopher A. Johnson, Kenneth W. Kinosian, Agnese Lagzda, Russell J. Lochrie, Michael W. May, Everardo Molina, Christopher L. Nagel, Henry J. Nagel, Kyle R. Peirce, Zachary R. Peirce, Mauricio E. Quiñonez, Ferenc Raksi, Kelanu Ranganath, Trevor Reutershan, Trevor Reutershan, Trevor Reutershan, Jimmie Salazar, Mitchell E. Schneider, Michael W. L. Seggebruch, Michael W. L. Seggebruch, Joy Y. Yang, Nathan H. Yeung, Collette B. Zapata, Luis E. Zapata, Eric J. Zepeda, Jingyuan Zhang   +50 more
exaly   +3 more sources

Very-High Energy Electron (VHEE) Studies at CERN's CLEAR User Facility

, 2018
Here we investigate how inserts of various densities (0.001-2.2 g/cm³) affect the dose distribution properties of VHEE beams at ~150 MeV. A range variation comparison was also made with clinical proton beams using TOPAS/GEANT4 Monte Carlo simulations. In
Jones, Roger, Farabolini, Wilfrid, Corsini, Roberto, Kirkby, Karen, Van Herk, Marcel, Lagzda, Agnese, Aitkenhead, Adam, MacKay, Ranald   +7 more
core   +2 more sources

Optics design and beam dynamics simulation for a VHEE radiobiology beam line at PRAE accelerator

Journal of Physics: Conference Series, 2019
The Platform for Research and Applications with Electrons (PRAE) is a multidisciplinary R&D; facility gathering subatomic physics, instrumentation, radiobiology and clinical research around a high-performance electron accelerator with beam energies up to
Dosanjh, Manjit, Prezado, Yolanda, Vallerand, Cynthia, Fouillade, Charles, Pouzoulet, Frederic, Delorme, Rachel, Favaudon, Vincent, Han, Yanliang, Bai, Bowen, Poortmans, Philip, Duchesne, Patricia, Faus-Golfe, Angeles   +11 more
core   +2 more sources

A multidisciplinary experimental and methodological investigation of electron and proton minibeams in the framework of the INFN MIRO project. [PDF]

Med Phys
Abstract Background The clinical translation of Minibeam RT (MBRT) has recently started thanks to the first human treatments recently performed. However, despite experimental evidence, the impact of the dose distribution parameters involved on the magnitude of the effect itself and the underlying radiobiological mechanisms are still only partially ...
Romano F, Zanacchi FC, Ciarrocchi E, Franciosini G, Milluzzo G, Scifoni E, Vignati A, Ahmad S, Arezzini S, Attili A, Battestini M, Bernardini J, Bettanin M, Bisio A, Bisogni MG, Bodrenko I, Bordieri G, Bravatà V, Burattini A, Camarda M, Cammarata FP, Capaccioli S, Castelli L, Cavalieri A, Celentano M, Chiadroni E, Cordoni FG, Corvaia E, Costa M, Curcio A, Da Pozzo E, De Felice M, Debbio FD, D'Errico F, D'Oca MC, D'Orsi B, Deut U, Durisi E, Fantacci ME, Farina S, Felici G, Ferro A, Ficcadenti L, Formuso A, Forte GI, Giordanengo S, Giuliano A, Giuliano L, Lanzanò L, Linsalata S, Lossano S, Maffei M, Marafini M, Marrale M, Massa M, Masturzo L, Mazzoni E, Migliorati M, Milian FM, Minafra L, Moggi A, Olivares DM, Montefiori M, Morrocchi M, Mostacci A, Mostardi F, Okpuwe C, Paiar F, Palumbo L, Patera V, Pensavalle JH, Pucci G, Quattrini F, Retico A, Rosso V, Russo G, Sacchi R, Sarti A, Scalisi S, Scapicchio C, Schiavi A, Stochino P, Strettoi E, Tommasino F, Tozzini V, Traini G, Trovato G, Usai A, Urso F, Martino FD.   +89 more
europepmc   +2 more sources

Implementation and validation of a very-high-energy electron model in the matRad treatment planning system. [PDF]

Med Phys
Abstract Background While electron beams of up to 20 MeV are commonly used in radiotherapy, the use of very‐high‐energy electrons (VHEEs) in the range of 100–200 MeV is now becoming a realistic option thanks to the recent advancements in accelerator technology.
Sitarz M, Ronga MG, Gesualdi F, Bonfrate A, Wahl N, De Marzi L.   +5 more
europepmc   +2 more sources

Proposal af a VHEE LINAC for FLASH radiotherapy [PDF]

, 2023
Translation of electron FLASH radiotherapy in clinical practice requires the use of high energy accelerators to treat deep tumours and Very High Electron Energy (VHEE) could represent a valid technique to achieve this goal.
L. Palumbo, M. Behtouei, B. Spataro, A. Patriarca, P. Cirrone, D. Francescone A. De Gregorio, L. Faillace, A. Gallo, L. Ficcadenti, F. Di Martino, L. Giuliano, M. Migliorati, S. Heinrich, G. Cuttone, G. Torrisi, M. G. Bisogni, V. Favaudon, J. H. Pensavalle, V. Patera, A. Vannozzi, A. Mostacci, F. Bosco, M. Carillo, D. De Arcangelis, A. Sarti D. Alesini, G. Franciosini   +25 more
core   +1 more source

Development and validation of a novel pulse optimization and beam control system for conventional and ultra high dose-per-pulse (FLASH) irradiation. [PDF]

Med Phys
Abstract Background FLASH radiotherapy requires precise control and minimal variation of dose per pulse (DPP). However, clinical linear accelerators and their beam control systems are designed to ensure accuracy of the temporally integrated dose and do not control for transient variations in DPP during radiation delivery.
Connell L, Esplen N, Lim R, Baikalov A, Coupey N, Nguyen C, Schüler E.   +6 more
europepmc   +2 more sources

Consensus statement on the exploration of clinical translation and application of electron ultra-high dose rate FLASH radiotherapy. [PDF]

Precis Radiat Oncol
• FLASH‐RT as a novel irradiation technique shows a protective effect on normal tissues while maintaining comparable tumor killing effect as CONV‐RT, also known as the FLASH effect. • We develop a consensus statement on the exploration of clinical translation of FLASH‐RT, and provide insights for the further application of this technology in clinical ...
Luo H, Yang C, Yue J, Ge H.
europepmc   +2 more sources

An experimental study of focused very high energy electron beams for radiotherapy

Communications Physics, 2021
Very high energy electrons (VHEE) penetrate deeply in tissues and can provide an alternative to photon irradiation for tumour treatment. Using VHEE beams at CERN Linear Electron Accelerator for Research (CLEAR) focused into a water phantom, the authors ...
Karolina Kokurewicz, Enrico Brunetti, Alessandro Curcio, Davide Gamba, Luca Garolfi, Antonio Gilardi, Eugenio Senes, Kyrre Ness Sjobak, Wilfrid Farabolini, Roberto Corsini, Dino Anthony Jaroszynski   +10 more
doaj   +1 more source

Deep Seated Tumour Treatments With Electrons of High Energy Delivered at FLASH Rates: The Example of Prostate Cancer

Frontiers in Oncology, 2021
Different therapies are adopted for the treatment of deep seated tumours in combination or as an alternative to surgical removal or chemotherapy: radiotherapy with photons (RT), particle therapy (PT) with protons or even heavier ions like 12C, are now ...
Alessio Sarti, Alessio Sarti, Patrizia De Maria, Giuseppe Battistoni, Micol De Simoni, Micol De Simoni, Cinzia Di Felice, Yunsheng Dong, Marta Fischetti, Marta Fischetti, Gaia Franciosini, Gaia Franciosini, Michela Marafini, Michela Marafini, Francesco Marampon, Ilaria Mattei, Riccardo Mirabelli, Riccardo Mirabelli, Silvia Muraro, Massimiliano Pacilio, Luigi Palumbo, Luigi Palumbo, Loredana Rocca, Damiana Rubeca, Angelo Schiavi, Angelo Schiavi, Adalberto Sciubba, Adalberto Sciubba, Vincenzo Tombolini, Marco Toppi, Marco Toppi, Giacomo Traini, Antonio Trigilio, Antonio Trigilio, Vincenzo Patera, Vincenzo Patera   +35 more
doaj   +1 more source