Results 11 to 20 of about 381 (150)

Proposal of a VHEE Linac for FLASH radiotherapy [PDF]

Journal of Physics: Conference Series, 2023
Abstract Translation of electron FLASH radiotherapy in clinical practice requires the use of high energy accelerators to treat deep tumours and Very High Electron Energy (VHEE) could represent a valid technique to achieve this goal. In this scenario, a VHEE FLASH linac is under study at the University La Sapienza of Rome (Italy) in ...
Giuliano, L, Bosco, F, Carillo, M, Arcangelis, D De, Ficcadenti, L, Francescone, D, Gregorio, A De, Franciosini, G, Migliorati, M, Mostacci, A, Palumbo, L, Patera, V, Sarti, A, Alesini, D, Behtouei, M, Faillace, L, Gallo, A, Spataro, B, Vannozzi, A, Cirrone, P, Cuttone, G, Torrisi, G, Bisogni, M G, Pensavalle, J H, Martino, F Di, Favaudon, V, Heinrich, S, Patriarca, A   +27 more
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Radiochromic film dosimetry for VHEE and UHDR: protocol adaptation and verification at the CLEAR facility [PDF]

Frontiers in Physics
Radiochromic films (RCFs) offer effective two-dimensional dosimetry with a simple, low-cost operating principle, making them suitable for very high-energy electron (VHEE) and ultra-high dose rate (UHDR) applications, where dosimetry standards are lacking.
Vilde F. Rieker, Vilde F. Rieker, Joseph J. Bateman, Laurence Wroe, Misael Caloz, Veljko Grilj, Ygor Q. Aguiar, Andreas Schüller, Claude Bailat, Wilfrid Farabolini, Antonio Gilardi, Cameron Robertson, Pierre Korysko, Pierre Korysko, Alexander Malyzhenkov, Steinar Stapnes, Steinar Stapnes, Marie-Catherine Vozenin, Manjit Dosanjh, Manjit Dosanjh, Roberto Corsini   +20 more
doaj   +4 more sources

Beam optics study for a potential VHEE beam delivery system [PDF]

Journal of Physics: Conference Series, 2023
AbstractVHEE (Very High Energy Electron) therapy can be superior to conventional radiotherapy for the treatment of deep seated tumours, whilst not necessarily requiring the space and cost of proton or heavy ion facilities. Developments in high gradient RF technology have allowed electrons to be accelerated to VHEE energies in a compact space, meaning ...
Robertson, CS, Burrows, PN, Dosanjh, M, Latina, A, Gerbershagen, A   +4 more
core   +8 more sources

Proposal of a compact VHEE-linac for FLASH radiotherapy [PDF]

Il Nuovo Cimento C, 2023
The present study regards the design of a Very High Electron Energy (VHEE) machine for use in radiotherapy to treat deep tumors in a FLASH regime. The proposed system includes a low energy, high current injector linac followed by high acceleration gradient structures capable of reaching 60-130MeV energy range. We used the CST code to define the linac's
Giuliano, L.
openaire   +4 more sources

Treatment planning for very high energy electrons: Studies that indicate the potential of the modality [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Radiotherapy using Very High Energy Electrons (VHEE) has the potential to reduce dose to organs at risk compared to photons.
James L. Bedford, Uwe Oelfke
doaj   +2 more sources

Start-to-end modelling of laser-plasma acceleration, beam transport and dose deposition of very high-energy electrons for radiotherapy [PDF]

Scientific Reports
The proposed radiotherapy using very high-energy electron (VHEE) beams generated by a laser-plasma accelerator has garnered significant interest due to its dose distribution capabilities and potential to address limitations of traditional photon-based ...
Rajakrishna Kalvala, Anton Golovanov, Arnaud Courvoisier, Tomer Friling, Eyal Kroupp, Lidan Grishko, Victor Malka   +6 more
doaj   +2 more sources

Testing the Properties of Beam-Dose Monitors for VHEE-FLASH Radiation Therapy [PDF]

, 2022
Very High Energy Electrons (VHEE) of 50 - 250 MeV are an attractive choice for FLASH radiation therapy (RT). Before VHEE-FLASH RT can be considered for clinical use, a reliable dosimetric and beam monitoring system needs to be developed, able to measure the dose delivered to the patient in real-time and cut off the beam in the event of a machine fault ...
Bateman, J. J., Burrows, P. N., Dosanjh, M., Dyks, L. A., Korysko, P., Corsini, R., Farabolini, W., Gerbershagen, A., Heracleous, N., Morales, S., Murtas, F., Rieker, V. F., Salvachua, B., Silari, M., Zorloni, G.   +14 more
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Deep Seated Tumour Treatments With Electrons of High Energy Delivered at FLASH Rates: The Example of Prostate Cancer [PDF]

Frontiers in Oncology, 2021
Different therapies are adopted for the treatment of deep seated tumours in combination or as an alternative to surgical removal or chemotherapy: radiotherapy with photons (RT), particle therapy (PT) with protons or even heavier ions like 12C, are now ...
Alessio Sarti, Alessio Sarti, Patrizia De Maria, Giuseppe Battistoni, Micol De Simoni, Micol De Simoni, Cinzia Di Felice, Yunsheng Dong, Marta Fischetti, Marta Fischetti, Gaia Franciosini, Gaia Franciosini, Michela Marafini, Michela Marafini, Francesco Marampon, Ilaria Mattei, Riccardo Mirabelli, Riccardo Mirabelli, Silvia Muraro, Massimiliano Pacilio, Luigi Palumbo, Luigi Palumbo, Loredana Rocca, Damiana Rubeca, Angelo Schiavi, Angelo Schiavi, Adalberto Sciubba, Adalberto Sciubba, Vincenzo Tombolini, Marco Toppi, Marco Toppi, Giacomo Traini, Antonio Trigilio, Antonio Trigilio, Vincenzo Patera, Vincenzo Patera   +35 more
doaj   +2 more sources

Optimizing focused very-high-energy electron beams for radiation therapy based on Monte Carlo simulation [PDF]

Scientific Reports
A TOPAS-based optimization program has been developed to precisely concentrate the dose of focused very-high-energy electron (VHEE) beams on deep-seated targets.
Chaofan An, Wei Zhang, Zeyi Dai, Jia Li, Xiong Yang, Jike Wang, Yuancun Nie   +6 more
doaj   +2 more sources

New insights on clinical perspectives of FLASH radiotherapy: from low- to very high electron energy [PDF]

Frontiers in Oncology, 2023
Radiotherapy (RT) is performed in approximately 75% of patients with cancer, and its efficacy is often hampered by the low tolerance of the surrounding normal tissues.
Stefano Ursino, Stefano Ursino, Stefano Ursino, Giovanni Gadducci, Giovanni Gadducci, Noemi Giannini, Noemi Giannini, Alessandra Gonnelli, Alessandra Gonnelli, Taiushia Fuentes, Taiushia Fuentes, Fabio Di Martino, Fabio Di Martino, Fabiola Paiar, Fabiola Paiar, Fabiola Paiar   +15 more
doaj   +2 more sources