Results 1 to 10 of about 704 (150)

Biological effects of conventional and ultra high dose rate radiation in human cells [PDF]

Scientific Reports
FLASH radiotherapy (FLASH-RT) that uses an ultra-high dose rate (UHDR) radiation is emerging as an effective cancer treatment modality but the biological effects of UHDR are not fully understood.
Terri L. Ryan, Maria B. Escalona, Kelsey O’Brien, Yuewen Tan, Karthik Kanagaraj, Maria Taveras, Leah Nemzow, Michelle Phillippi, Naresh Deoli, Eric Wang, Igor Shuryak, Guy Garty, Helen C. Turner, Adayabalam S. Balajee   +13 more
doaj   +3 more sources

First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy [PDF]

Physics and Imaging in Radiation Oncology
Within this study, we demonstrated the feasibility of ultra-high dose rate (UHDR) oxygen ion irradiation at three different levels of biological complexity. The difference in oxygen consumption between UHDR and standard dose rates (SDR) was negligible in
Celine Karle, Domenico I. Filosa, Mahdi Akbarpour, Nora Schuhmacher, Stephan Brons, Rainer Cee, Christian Schömers, Stefan Scheloske, Kristoffer Petersson, Thomas Haberer, Amir Abdollahi, Jürgen Debus, Thomas Tessonnier, Mahmoud Moustafa, Andrea Mairani, Ivana Dokic   +15 more
doaj   +3 more sources

Experimental characterization of proton minibeam therapy delivery under FLASH dose-rate conditions [PDF]

Scientific Reports
Proton minibeam radiation therapy (pMBRT) introduces spatial fractionation of dose distributions at submillimeter resolution, offering a promising approach to reducing normal tissue toxicity while maintaining effective tumor control.
Yuting Lin, Wei Wu, Jufri Setianegara, Aoxiang Wang, Nicolas Gerard, Jarrick Nys, Gregory N. Gan, Hao Gao   +7 more
doaj   +2 more sources

Preclinical validation of a clinical prototype of intraoperative electron FLASH radiotherapy equipment: key evidence for a new radiotherapy paradigm [PDF]

Radiation Oncology
Background and purpose This study aimed to evaluate whether the clinical prototype of intraoperative electron FLASH radiotherapy (CPIO-EFLASH), with a source-surface distance (SSD) of 50 cm, could achieve ultra-high dose rates, effectively control tumors,
Xiaofei Hao, Huan Du, Binwei Lin, Yang Xia, Mingming Tang, Wei Wu, Decai Wang, Yihan Zhu, Yu Zhang, Jianxin Wang, Yiwei Yang, Dai Wu, Xiaobo Du   +12 more
doaj   +2 more sources

Human fibrosarcoma cells selected for ultra-high doxorubicin resistance, acquire trabectedin cross-resistance, remain sensitive to recombinant methioninase, and have increased c-MYC expression [PDF]

Frontiers in Oncology
BackgroundDoxorubicin is standard first-line chemotherapy for soft-tissue sarcoma (STS), yet the emergence of resistance severely limits its clinical efficacy.
Sei Morinaga, Sei Morinaga, Sei Morinaga, Qinghong Han, Kohei Mizuta, Kohei Mizuta, Byung Mo Kang, Byung Mo Kang, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Hiroyuki Tsuchiya, Satoru Demura, Robert M. Hoffman, Robert M. Hoffman   +18 more
doaj   +2 more sources

Development and application of in-vivo dose and time-resolved measurements for clinical application of ultra-high dose rate radiotherapy [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Ultra-high-dose-rate (UHDR) radiotherapy (RT) has emerged as a promising technique to widen the therapeutic window. However, clinical implementation is critically dependent on standardized dosimetry systems.
Riccardo Dal Bello, Serena Psoroulas, Dominik Flückiger, Jerome Krayenbühl, Arvid Kemper, Rafael Kranzer, Benjamin Côté, Jens von der Grün, Panagiotis Balermpas, Matthias Guckenberger, Stephanie Tanadini-Lang   +10 more
doaj   +2 more sources

Development and characterization of phantoms to investigate the Flash effect with Drosophila melanogaster at an ultra-high dose rate radiotherapy linac [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Ultra-high dose rate (UHDR) radiotherapy may widen the therapeutic window thanks to the Flash effect. Experimental linear accelerators have been converted to UHDR to collect pre-clinical evidence.
Riccardo Dal Bello, Marvin Kreuzer, Irene Vetrugno, Jamie C. Little, Rafael Kranzer, Stefan Schischke, Lily Bossin, Eduardo Gardenali Yukihara, Matthias Guckenberger, Martin Pruschy, Stephanie Tanadini-Lang   +10 more
doaj   +2 more sources

Radioluminescence 3D dose reconstruction for FLASH and conventional radiotherapy [PDF]

Scientific Reports
FLASH radiotherapy requires dosimetric techniques capable of operating at ultra-high dose rates (UHDR), where conventional detectors often suffer from saturation, limited temporal resolution or lack of spatial information. Radioluminescence imaging (RLI)
Stefano Pizzardi, Lisa Alborghetti, Federica Vurro, Lucia Perna, Sara Broggi, Fabio Di Martino, Luigi Masturzo, Andrea Cavalieri, Claudio Fiorino, Antonello Enrico Spinelli   +9 more
doaj   +2 more sources

Online Recombination Correction in Dosimetry with Arrays of Ionization Chambers: Application to FFF and UHDR Radiotherapy

Applied Sciences (Switzerland), 2021
Recombination of charge carriers can affect the response of ionization detectors used for the dosimetry of radiotherapy fields. In this work, we present a method for correcting online the recombination effects in arrays of ionization chambers irradiated ...
Juan Pardo-Montero, JOSÉ Paz-Martín, Faustino Gomez   +2 more
exaly   +3 more sources

Dosimetric characterization of a novel UHDR megavoltage X-ray source for FLASH radiobiological experiments

Scientific Reports
A first irradiation platform capable of delivering 10 MV X-ray beams at ultra-high dose rates (UHDR) has been developed and characterized for FLASH radiobiological research at TRIUMF.
Nolan Esplen, Magdalena Bazalova-Carter, Ren Xi   +2 more
exaly   +2 more sources