Results 1 to 10 of about 1,557 (136)
Scientific ReportsA first irradiation platform capable of delivering 10 MV X-ray beams at ultra-high dose rates (UHDR) has been developed and characterized for FLASH radiobiological research at TRIUMF.
Stephanie Rädel, Hui-Wen Koay
exaly +3 more sources
Frontiers in PhysicsRadiochromic films (RCFs) offer effective two-dimensional dosimetry with a simple, low-cost operating principle, making them suitable for very high-energy electron (VHEE) and ultra-high dose rate (UHDR) applications, where dosimetry standards are lacking.
Wilfrid Farabolini
exaly +4 more sources
Quantum Beam ScienceFLASH-radiotherapy (RT) presents great potential as an alternative to conventional radiotherapy methods in cancer treatment. In this paper, we focus on simulation studies for a linear particle accelerator injector design using the ASTRA code, which ...
Nick Vordos +2 more
exaly +4 more sources
Deciphering Ultra-High Dose Rate Irradiation with Drosophila melanogaster [PDF]
AntioxidantsFLASH RT, which employs ultra-high dose rates (UHDR), has shown potential in reducing irradiation-induced damage to normal tissue while maintaining effective tumor targeting.
Marvin Kreuzer +10 more
doaj +2 more sources
Physica MedicaOBJECTIVE This study aimed to evaluate and validate the new FLASHKNiFE ultra-high dose rate (UHDR) radiotherapy system by commissioning and assessing the dosimetric performance of its electron UHDR beams to ensure accuracy and stability.
Charlotte Robert +2 more
exaly +2 more sources
Ultra-high-dose-rate pulsed irradiation and the conditional FLASH effect: dosimetry, multiscale biology, and clinical translation [PDF]
Frontiers in OncologyUltra-high-dose-rate (UHDR) pulsed irradiation can deliver therapeutic doses within an extremely short time window, but UHDR is a physical delivery state, whereas the FLASH effect is a conditional comparative phenotype in which normal-tissue injury is ...
Jincheng Zhang +5 more
doaj +2 more sources
Mitochondrial remodeling after conventional and ultra-high dose rate irradiation in head and neck carcinoma cells in vitro [PDF]
Clinical and Translational Radiation OncologyBackground and purpose: Ultra-high dose rate (UHDR) irradiation is being investigated as a strategy to widen the therapeutic window of radiotherapy, but the biological mechanisms that distinguish UHDR from conventional dose rate (CONV) irradiation remain
Liliana L. Silva +8 more
doaj +2 more sources
Medical PhysicsBackground: The extremely fast delivery of doses with ultra high dose rate (UHDR) beams necessitates the investigation of novel approaches for real‐time dosimetry and beam monitoring.
Fabio Di Martino +2 more
exaly +2 more sources
Radiation protection considerations for ultra-high dose rate proton beam FLASH research: consensus from multi-institutional experience [PDF]
Frontiers in OncologyThe use of ultra-high dose rate (UHDR) radiation for radiotherapy could potentially improve outcomes for cancer patients by increasing healthy tissue sparing, known as the FLASH effect.
Michael J. Taylor +12 more
doaj +2 more sources
Imaging System for Real-Time, Full-Field Pulse-by-Pulse Surface Dosimetry of UHDR Electron Beams
Medical PhysicsThe interest in ultra‐high dose rate (UHDR) radiation therapy (RT) has grown due to its potential to spare normal tissue. However, clinical application is hindered by dosimetry challenges, as current irradiators and dosimeters are not designed for UHDR's
Rongxiao Zhang, Petr Bruza, Megan Clark
exaly +2 more sources