Results 31 to 40 of about 2,071 (173)

Preclinical validation of a clinical prototype of intraoperative electron FLASH radiotherapy equipment: key evidence for a new radiotherapy paradigm [PDF]

Radiation Oncology
Background and purpose This study aimed to evaluate whether the clinical prototype of intraoperative electron FLASH radiotherapy (CPIO-EFLASH), with a source-surface distance (SSD) of 50 cm, could achieve ultra-high dose rates, effectively control tumors,
Xiaofei Hao, Huan Du, Binwei Lin, Yang Xia, Mingming Tang, Wei Wu, Decai Wang, Yihan Zhu, Yu Zhang, Jianxin Wang, Yiwei Yang, Dai Wu, Xiaobo Du   +12 more
doaj   +2 more sources

Human fibrosarcoma cells selected for ultra-high doxorubicin resistance, acquire trabectedin cross-resistance, remain sensitive to recombinant methioninase, and have increased c-MYC expression [PDF]

Frontiers in Oncology
BackgroundDoxorubicin is standard first-line chemotherapy for soft-tissue sarcoma (STS), yet the emergence of resistance severely limits its clinical efficacy.
Sei Morinaga, Sei Morinaga, Sei Morinaga, Qinghong Han, Kohei Mizuta, Kohei Mizuta, Byung Mo Kang, Byung Mo Kang, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Hiroyuki Tsuchiya, Satoru Demura, Robert M. Hoffman, Robert M. Hoffman   +18 more
doaj   +2 more sources

Imaging and characterization of optical emission from ex vivo tissue during conventional and UHDR PBS proton therapy

Physics in Medicine and Biology
Objective. Imaging of optical photons emitted from tissue during radiotherapy is a promising technique for real-time visualization of treatment delivery, offering applications in dose verification, treatment monitoring, and retrospective treatment plan ...
R. Vasyltsiv, Mahbubur Rahman, J. Harms, M. Clark, D. Gladstone, B. Pogue, Rong-Xiao Zhang, P. Brůža   +7 more
semanticscholar   +2 more sources

Preliminary study of luminescence phenomena from various materials under ultra-high dose rate proton beam irradiation for dose management [PDF]

Scientific Reports
This research aimed to identify materials capable of emitting visible light useful for dose management at ultra-high dose rate (uHDR). Various materials were irradiated with proton beams at a normal dose rate (NDR) and uHDR, and the resulting surface ...
Ryosaku Yamada, Teiji Nishio, Daiki Kinkawa, Taketo Tanaka, Mizuki Omura, Yoji Tabata, Hitoshi Yoshimura, Jun Kataoka   +7 more
doaj   +2 more sources

Development and application of in-vivo dose and time-resolved measurements for clinical application of ultra-high dose rate radiotherapy [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Ultra-high-dose-rate (UHDR) radiotherapy (RT) has emerged as a promising technique to widen the therapeutic window. However, clinical implementation is critically dependent on standardized dosimetry systems.
Riccardo Dal Bello, Serena Psoroulas, Dominik Flückiger, Jerome Krayenbühl, Arvid Kemper, Rafael Kranzer, Benjamin Côté, Jens von der Grün, Panagiotis Balermpas, Matthias Guckenberger, Stephanie Tanadini-Lang   +10 more
doaj   +2 more sources

Development and characterization of a dedicated dose monitor for ultrahigh-dose-rate scanned carbon-ion beams [PDF]

Scientific Reports
The current monochromatic beam mode (i.e., uHDR irradiation mode) of the scanned carbon-ion beam lacks a dedicated dose monitor, making the beam control challenging.
Masashi Yagi, Shinichi Shimizu, Noriaki Hamatani, Takuto Miyoshi, Takuya Nomura, Takashi Toyoda, Mahoro Nakatani, Toshiro Tsubouchi, Masaki Shimizu, Yoshiaki Kuwana, Masumi Umezawa, Masaaki Takashina, Teiji Nishio, Masahiko Koizumi, Kazuhiko Ogawa, Tatsuaki Kanai   +15 more
doaj   +2 more sources

C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect [PDF]

Clinical and Translational Radiation Oncology
This study explores the effects of UHDR irradiation on Caenorhabditis elegans embryos. UHDR proton and electron beams demonstrate a sparing effect, aligning with literature findings. This highlights C.
Lucas Schoenauen, François-Xavier Stubbe, Dirk Van Gestel, Sébastien Penninckx, Anne-Catherine Heuskin   +4 more
doaj   +2 more sources

Radioluminescence 3D dose reconstruction for FLASH and conventional radiotherapy [PDF]

Scientific Reports
FLASH radiotherapy requires dosimetric techniques capable of operating at ultra-high dose rates (UHDR), where conventional detectors often suffer from saturation, limited temporal resolution or lack of spatial information. Radioluminescence imaging (RLI)
Stefano Pizzardi, Lisa Alborghetti, Federica Vurro, Lucia Perna, Sara Broggi, Fabio Di Martino, Luigi Masturzo, Andrea Cavalieri, Claudio Fiorino, Antonello Enrico Spinelli   +9 more
doaj   +2 more sources

In-Vivo Dosimetry for Ultra-High Dose Rate (UHDR) Electron Beam FLASH Radiotherapy Using an Organic (Plastic), an Organic–Inorganic Hybrid and an Inorganic Point Scintillator System

Photonics
Dosimetry is crucial in radiotherapy to warrant safe and correct treatment. In FLASH radiotherapy, where ultra-high dose rates (UHDRs) are used, the dosimetric demands are more stringent, requiring the development and investigation of new dosemeters.
Verdi Vanreusel, Hugo Vallet, Jordi Wijnen, Benjamin Côté, Paul Leblans, Paul Sterckx, Dirk Vandenbroucke, Dirk Verellen, Luana de Freitas Nascimento   +8 more
doaj   +2 more sources

Evaluation of a Faraday cup-style detector as a beam diagnostic system for ultra-high dose rate (FLASH) electron beams. [PDF]

J Appl Clin Med Phys
Abstract Background Beam diagnostic systems are essential for the development and quality assurance of ultra‐high dose rate (UHDR) radiation sources to enable reliable delivery of FLASH radiotherapy (RT). Critically, suitable beam diagnostic systems for electron FLASH sources are lacking.
Lopez A, Baikalov A, Liu K, Esplen N, Bartzsch S, Schüler E.   +5 more
europepmc   +2 more sources