Results 31 to 40 of about 704 (150)

Design of an ultra-high dose rate cell irradiation experimental platform using a medical proton linear injector

He jishu, 2023
BackgroundUltra-high dose rate (UHDR) radiation of electron or proton beam has been shown to spare normal tissues surrounding the tumors while killing tumor cells effectively which is called the FLASH effect (FE).
LIU Junya, YU Xiao, WU Chao, SUN Xiangshang, SHANG Haijiao, LIAO Wentao, YAN Nan, ZHOU Yun, PU Yuehu   +8 more
doaj   +1 more source

Linear mixed effects models for RNFL-G thickness, RNFL-T thickness, and macular volume in the Huntington’s disease group with UHDR TMS and disease duration as fixed effects.

, 2023
Linear mixed effects models for RNFL-G thickness, RNFL-T thickness, and macular volume in the Huntington’s disease group with UHDR TMS and disease duration as fixed effects.
Olga Ulmanova (14675370), Jiri Klempir (13227643), Ales Kopal (14675367), Jana Lizrova Preiningerova (14675373), Jan Roth (419817), Michaela Brichova (10750969), Pavel Dusek (14675364)   +6 more
core   +1 more source

Across the stages: a multiscale extension of the generalized stochastic microdosimetric model (MS-GSM2) to include the ultra-high dose rate

Frontiers in Physics, 2023
Ultra-high dose rate (UHDR) irradiations with different types of radiation have shown a larger sparing of normal tissue and unchanged tumor control with respect to conventional delivery.
Marco Battestini, Marco Battestini, Marta Missiaggia, Andrea Attili, Francesco Tommasino, Francesco Tommasino, Chiara La Tessa, Francesco G. Cordoni, Francesco G. Cordoni, Emanuele Scifoni   +9 more
doaj   +1 more source

Deciphering Ultra-High Dose Rate Irradiation with Drosophila melanogaster

Antioxidants
FLASH RT, which employs ultra-high dose rates (UHDR), has shown potential in reducing irradiation-induced damage to normal tissue while maintaining effective tumor targeting.
Marvin Kreuzer, Irene Vetrugno, Riccardo Dal Bello, Stephanie Tanadini-Lang, Erich Brunner, Darlina von Salis, Damian Manetsch, Sandipan Tewary, Matthias Guckenberger, Jamie Little, Martin Pruschy   +10 more
doaj   +1 more source

Absolute dosimetry for FLASH proton pencil beam scanning radiotherapy

Scientific Reports, 2023
A paradigm shift is occurring in clinical oncology exploiting the recent discovery that short pulses of ultra-high dose rate (UHDR) radiation—FLASH radiotherapy—can significantly spare healthy tissues whilst still being at least as effective in curing ...
Ana Lourenço, Anna Subiel, Nigel Lee, Sam Flynn, John Cotterill, David Shipley, Francesco Romano, Joe Speth, Eunsin Lee, Yongbin Zhang, Zhiyan Xiao, Anthony Mascia, Richard A. Amos, Hugo Palmans, Russell Thomas   +14 more
doaj   +1 more source

Ultra‐high dose rate radiation production and delivery systems intended for FLASH

, 2022
Higher dose rates, a trend for radiotherapy machines, can be beneficial in shortening treatment times for radiosurgery and mitigating the effects of motion.
Farr, J., Victor Malka, Veljko Grilj, Grilj, V., Grilj, Veljko, Sudharsan, Srinivasan, Srinivasan Sudharsan, Malka, Victor, Farr, Jonathan, Malka, V., Jonathan Farr, Schippers, Marco, Sudharsan, S., Schippers, M., Marco Schippers   +14 more
core   +1 more source

A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply

Frontiers in Oncology, 2022
IntroductionRadiation-induced oxygen depletion in tissue is assumed as a contributor to the FLASH sparing effects. In this study, we simulated the heterogeneous oxygen depletion in the tissue surrounding the vessels and calculated the proton FLASH ...
Wei Zou, Haram Kim, Eric S. Diffenderfer, David J. Carlson, Cameron J. Koch, Ying Xiao, BoonKeng K. Teo, Michele M. Kim, James M. Metz, Yi Fan, Amit Maity, Costas Koumenis, Theresa M. Busch, Rodney Wiersma, Keith A. Cengel, Lei Dong   +15 more
doaj   +1 more source

Systematic Review of the Huntington's Disease Drug Development Pipeline, 2014 to 2025

Movement Disorders, EarlyView.
Abstract Background In the past decade, significant advances have improved our understanding of the mechanisms underlying HD pathobiology leading to several putative therapeutic targets for HD. Objective The aim was to describe the Huntington's disease (HD) drug development clinical pipeline.
Pavlina Konstantinova, Jenny Townhill, Juliana Bronzova, Viktoria Andreeva, Swati Sathe, Cristina Sampaio   +5 more
wiley   +1 more source

First evidence of in vivo effect of FLASH radiotherapy with helium ions in zebrafish embryos

, 2023
International audienceThe ability to reduce toxicity of ultra-high dose rate (UHDR) helium ion irradiation has not been reported in vivo. Here, we tested UHDR helium ion irradiation in an embryonic zebrafish model.
Guillaume Blain, Lydia Maigne, Evin, Manon, Gaëlle Saade, Stéphane Supiot, Vincent Potiron, Youssef Ghannam, Sophie Chiavassa, Ghannam, Youssef, Haddad, Ferid, Blain, Guillaume, Supiot, Stéphane, Mouchard, Quentin, Koumeir, Charbel, Servagent, Noël, Potiron, Vincent, Manon Evin, Quentin Mouchard, Saade, Gaëlle, Charbel Koumeir, Grégory Delpon, Chiavassa, Sophie, Maigne, Lydia, Delpon, Grégory, Ferid Haddad, Noël Servagent   +25 more
core   +1 more source

Hyperhomocysteinemia and Vitamin B Deficiency as Potential Aggravating Factors in Huntington's Disease: A Prospective Monocentric Study

Movement Disorders, EarlyView.
Abstract Background Although not confirmed, some studies have suggested that elevated homocysteine levels are common in patients with Huntington's disease (HD). Its clinical relevance remains unclear. Objectives We aimed to assess vitamin B and homocysteine levels in HD patients and explore the relationships among hyperhomocysteinemia, vitamin B ...
Salomé Puisieux, Elise Pourié, Céline Bonnet, Lucie Hopes, Solène Frismand, Myriam Bronner, Virginie Roth, Marion Wandzel, Natacha Sloboda, Laetitia Lambert, Abderrahim Oussalah, Amélia Julien, Irina Rotaru, Rosa‐Maria Guéant‐Rodriguez, Jean Louis Guéant, Carine Bossenmeyer‐Pourié, Mathilde Renaud   +16 more
wiley   +1 more source