Results 11 to 20 of about 704 (150)

Simulation Dosimetry Studies for FLASH Radiation Therapy (RT) with Ultra-High Dose Rate (UHDR) Electron Beam

Quantum Beam Science
FLASH-radiotherapy (RT) presents great potential as an alternative to conventional radiotherapy methods in cancer treatment. In this paper, we focus on simulation studies for a linear particle accelerator injector design using the ASTRA code, which ...
Nikolaos Gazis, Emmanouil Trachanas, N Vordos   +2 more
exaly   +4 more sources

Comparison of Gonadal Toxicity of Single-Fraction Ultra-High Dose Rate and Conventional Radiation in Mice

Advances in Radiation Oncology, 2023
Purpose: Increasing evidence suggests that ultra-high-dose-rate (UHDR) radiation could result in similar tumor control as conventional (CONV) radiation therapy (RT) while reducing toxicity to surrounding healthy tissues.
Maria C. Cuitiño, DVM, PhD, Jessica L. Fleming, PhD, Sagarika Jain, MS, Ashley Cetnar, PhD, Ahmet S. Ayan, PhD, Jeffrey Woollard, PhD, Heather Manring, PhD, Wei Meng, PhD, Joseph P. McElroy, PhD, Dukagjin M. Blakaj, MD, PhD, Nilendu Gupta, PhD, Arnab Chakravarti, MD   +11 more
doaj   +2 more sources

Radiobiology experiments with a laser driven x-ray source: Exploring the UHDR regime [PDF]

EPJ Web of Conferences, 2023
Laser Driven Plasma Accelerators (LDPA) can generate both characteristic and Bremsstrahlung x-rays in ultrashort bunches. Because of the high intensity of the laser pulses, these laser-induced x-ray sources can achieve peak dose rates compatible with the
Reija A., Contreras-Martínez R., Coathup A., Barranco F., Juan J., Alejo A., Bembibre A., Benlliure J., Peñas J., Aguado-Barrera M.E., Vega A., Ruiz C., Seimetz M.   +12 more
doaj   +2 more sources

Development and characterization of a dedicated dose monitor for ultrahigh-dose-rate scanned carbon-ion beams [PDF]

Scientific Reports
The current monochromatic beam mode (i.e., uHDR irradiation mode) of the scanned carbon-ion beam lacks a dedicated dose monitor, making the beam control challenging.
Masashi Yagi, Shinichi Shimizu, Noriaki Hamatani, Takuto Miyoshi, Takuya Nomura, Takashi Toyoda, Mahoro Nakatani, Toshiro Tsubouchi, Masaki Shimizu, Yoshiaki Kuwana, Masumi Umezawa, Masaaki Takashina, Teiji Nishio, Masahiko Koizumi, Kazuhiko Ogawa, Tatsuaki Kanai   +15 more
doaj   +2 more sources

Characterization of an Inorganic Powder-Based Scintillation Detector Under a UHDR Electron Beam

Sensors
(1) Background: Ultra-high dose rate (UHDR) radiation therapy needs a reliable dosimetry solution and scintillation detectors are promising candidates.
Daline Tho, Sam Beddar
doaj   +3 more sources

Radiochromic film dosimetry for VHEE and UHDR: protocol adaptation and verification at the CLEAR facility

Frontiers in Physics
Radiochromic films (RCFs) offer effective two-dimensional dosimetry with a simple, low-cost operating principle, making them suitable for very high-energy electron (VHEE) and ultra-high dose rate (UHDR) applications, where dosimetry standards are lacking.
Vilde F. Rieker, Vilde F. Rieker, Joseph J. Bateman, Laurence Wroe, Misael Caloz, Veljko Grilj, Ygor Q. Aguiar, Andreas Schüller, Claude Bailat, Wilfrid Farabolini, Antonio Gilardi, Cameron Robertson, Pierre Korysko, Pierre Korysko, Alexander Malyzhenkov, Steinar Stapnes, Steinar Stapnes, Marie-Catherine Vozenin, Manjit Dosanjh, Manjit Dosanjh, Roberto Corsini   +20 more
doaj   +3 more sources

Reactive Oxygen Species Yield near Gold Nanoparticles Under Ultrahigh-Dose-Rate Electron Beams: A Monte Carlo Study [PDF]

Nanomaterials
Ultrahigh dose rate (UHDR) radiotherapy, also known as FLASH radiotherapy (FLASH-RT), has shown potential for increasing tumor control while sparing normal tissue.
Chloe Doen Kim, James C. L. Chow
doaj   +2 more sources

Anesthesia is a potent determinant of ultra-high dose rate sparing in the murine total abdominal irradiation model [PDF]

Frontiers in Oncology
IntroductionRadiation therapy is a mainstay of treatment for numerous gastrointestinal (GI) malignancies, where our ability to deliver dose to tumors is limited by acute GI toxicity. Ultra-high dose-rate (UHDR) ‘FLASH’ irradiation can spare normal tissue,
Armin D. Tavakkoli, Armin D. Tavakkoli, William W. Daley, David I Hunter, Beverly A. Allen, Gretchen C. Carpenter, David J. Gladstone, Brian W. Pogue, P. Jack Hoopes, P. Jack Hoopes   +9 more
doaj   +2 more sources

C. elegans: A potent model for high-throughput screening experiments investigating the FLASH effect [PDF]

Clinical and Translational Radiation Oncology
This study explores the effects of UHDR irradiation on Caenorhabditis elegans embryos. UHDR proton and electron beams demonstrate a sparing effect, aligning with literature findings. This highlights C.
Lucas Schoenauen, François-Xavier Stubbe, Dirk Van Gestel, Sébastien Penninckx, Anne-Catherine Heuskin   +4 more
doaj   +2 more sources

In-Vivo Dosimetry for Ultra-High Dose Rate (UHDR) Electron Beam FLASH Radiotherapy Using an Organic (Plastic), an Organic–Inorganic Hybrid and an Inorganic Point Scintillator System

Photonics
Dosimetry is crucial in radiotherapy to warrant safe and correct treatment. In FLASH radiotherapy, where ultra-high dose rates (UHDRs) are used, the dosimetric demands are more stringent, requiring the development and investigation of new dosemeters.
Verdi Vanreusel, Hugo Vallet, Jordi Wijnen, Benjamin Côté, Paul Leblans, Paul Sterckx, Dirk Vandenbroucke, Dirk Verellen, Luana de Freitas Nascimento   +8 more
doaj   +2 more sources