Results 11 to 20 of about 2,071 (173)

Effects of UHDR and Conventional Irradiation on Behavioral and Cognitive Performance and the Percentage of Ly6G+ CD45+ Cells in the Hippocampus

International Journal of Molecular Sciences, 2023
We assessed the effects of conventional and ultra-high dose rate (UHDR) electron irradiation on behavioral and cognitive performance one month following exposure and assessed whether these effects were associated with alterations in the number of immune ...
Jacob Raber, P Jack Hoopes, Ariel Chaklai   +2 more
exaly   +3 more sources

Feasibility of Synchrotron-Based Ultra-High Dose Rate (UHDR) Proton Irradiation With Pencil Beam Scanning for FLASH Research

Cancers
Simple Summary Ultra-high dose rate (UHDR) irradiation in proton therapy has mostly been performed using a cyclotron system so far. In this study, we present our approach to achieve an ultra-high dose rate for a clinical synchrotron proton therapy system
Xun Jia, Lingshu Yin, John W Wong
exaly   +3 more sources

Characterization of an Inorganic Powder-Based Scintillation Detector Under a UHDR Electron Beam [PDF]

Sensors
(1) Background: Ultra-high dose rate (UHDR) radiation therapy needs a reliable dosimetry solution and scintillation detectors are promising candidates.
Daline Tho, Sam Beddar
doaj   +3 more sources

Optically stimulated luminescence system as an alternative for radiochromic film for 2D reference dosimetry in UHDR electron beams. [PDF]

Physica medica (Testo stampato), 2023
Radiotherapy is part of the treatment of over 50% of cancer patients. Its efficacy is limited by the radiotoxicity to the healthy tissue. FLASH-RT is based on the biological effect that ultra-high dose rates (UHDR) and very short treatment times strongly
V. Vanreusel, A. Gasparini, F. Galante, Giulia Mariani, M. Pacitti, A. Colijn, B. Reniers, B. Yalvac, D. Vandenbroucke, Mark J. G. Peeters, P. Leblans, G. Felici, L. de Freitas Nascimento, D. Verellen   +13 more
semanticscholar   +4 more sources

Comparison of Gonadal Toxicity of Single-Fraction Ultra-High Dose Rate and Conventional Radiation in Mice

Advances in Radiation Oncology, 2023
Purpose: Increasing evidence suggests that ultra-high-dose-rate (UHDR) radiation could result in similar tumor control as conventional (CONV) radiation therapy (RT) while reducing toxicity to surrounding healthy tissues.
Maria C. Cuitiño, DVM, PhD, Jessica L. Fleming, PhD, Sagarika Jain, MS, Ashley Cetnar, PhD, Ahmet S. Ayan, PhD, Jeffrey Woollard, PhD, Heather Manring, PhD, Wei Meng, PhD, Joseph P. McElroy, PhD, Dukagjin M. Blakaj, MD, PhD, Nilendu Gupta, PhD, Arnab Chakravarti, MD   +11 more
doaj   +2 more sources

Characterization of silicon carbide diodes as cost‐effective active detectors for proton UHDR dosimetry

Medical Physics (Lancaster)
Proton therapy allows for better localization of the dose distribution in the tumor. In addition, the FLASH effect can be exploited to reduce the toxicity to healthy tissue by using short‐pulsed treatment at ultra‐high dose rates (UHDR).
Ivan Lopez Paz, C. Fleta, P. Ibáñez, Á. Henao, D. Sánchez-Parcerisa, A. Zazpe, I. Del Monte-Garcia, C. Guardiola   +7 more
semanticscholar   +2 more sources

First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy

Physics and Imaging in Radiation Oncology
Within this study, we demonstrated the feasibility of ultra-high dose rate (UHDR) oxygen ion irradiation at three different levels of biological complexity. The difference in oxygen consumption between UHDR and standard dose rates (SDR) was negligible in
Celine Karle, Domenico I. Filosa, Mahdi Akbarpour, Nora Schuhmacher, Stephan Brons, Rainer Cee, Christian Schömers, Stefan Scheloske, Kristoffer Petersson, Thomas Haberer, Amir Abdollahi, Jürgen Debus, Thomas Tessonnier, Mahmoud Moustafa, Andrea Mairani, Ivana Dokic   +15 more
doaj   +2 more sources

First Characterization of Novel Silicon Carbide Detectors with Ultra-High Dose Rate Electron Beams for FLASH Radiotherapy [PDF]

Applied Sciences, 2023
Ultra-high dose rate (UHDR) beams for FLASH radiotherapy present significant dosimetric challenges. Although novel approaches for decreasing or correcting ion recombination in ionization chambers are being proposed, applicability of ionimetric dosimetry ...
Francesco Romano, Giuliana Milluzzo, Fabio Di Martino, Maria Cristina D’Oca, Giuseppe Felici, Federica Galante, Alessia Gasparini, Giulia Mariani, Maurizio Marrale, Elisabetta Medina, Matteo Pacitti, Enrico Sangregorio, Verdi Vanreusel, Dirk Verellen, Anna Vignati, Massimo Camarda   +15 more
doaj   +3 more sources

Ultrahigh-Dose-Rate Proton Irradiation Elicits Reduced Toxicity in Zebrafish Embryos [PDF]

Advances in Radiation Oncology, 2023
Purpose: Recently, ultrahigh-dose-rate radiation therapy (UHDR-RT) has emerged as a promising strategy to increase the benefit/risk ratio of external RT. Extensive work is on the way to characterize the physical and biological parameters that control the
Gaëlle Saade, Eva Bogaerts, Sophie Chiavassa, PhD, Guillaume Blain, Grégory Delpon, PhD, Manon Evin, Youssef Ghannam, Ferid Haddad, PhD, Karin Haustermans, MD, PhD, Charbel Koumeir, PhD, Ellina Macaeva, PhD, Lydia Maigne, PhD, Quentin Mouchard, PhD, Noël Servagent, PhD, Edmond Sterpin, PhD, Stéphane Supiot, MD, PhD, Vincent Potiron, PhD   +16 more
doaj   +2 more sources

Design and Characterization of a Novel Scintillator Array for UHDR PBS Proton Therapy Surface Dosimetry

Medical Physics
Ultrahigh dose rate (UHDR) proton therapy has shown promise in normal tissue sparing by enhancing the therapeutic ratio through a method termed the FLASH effect.
Rongxiao Zhang, David Gladstone, Petr Bruza   +2 more
exaly   +2 more sources