Results 21 to 30 of about 2,071 (173)

Quantitative, Real-Time Scintillation Imaging for Experimental Comparison of Different Dose and Dose Rate Estimations in UHDR Proton Pencil Beams

Medical Physics
Ultra‐high dose rate radiotherapy (UHDR‐RT) has demonstrated normal tissue sparing capabilities, termed the FLASH effect; however, available dosimetry tools make it challenging to characterize the UHDR beams with sufficiently high concurrent spatial and ...
Rongxiao Zhang, Petr Bruza, Megan Clark
exaly   +2 more sources

Experimental characterization of proton minibeam therapy delivery under FLASH dose-rate conditions [PDF]

Scientific Reports
Proton minibeam radiation therapy (pMBRT) introduces spatial fractionation of dose distributions at submillimeter resolution, offering a promising approach to reducing normal tissue toxicity while maintaining effective tumor control.
Yuting Lin, Wei Wu, Jufri Setianegara, Aoxiang Wang, Nicolas Gerard, Jarrick Nys, Gregory N. Gan, Hao Gao   +7 more
doaj   +2 more sources

Characterization of Commercial Detectors for Absolute Proton UHDR Dosimetry on a Compact Clinical Proton Synchrocyclotron

Medical Physics
Modern compact proton synchrocyclotrons can achieve ultra‐high dose rates ( ≥$ \ge $ 40 Gy/s) to support ultra‐high‐dose‐rate (UHDR) preclinical experiments utilizing pencil beam scanning (PBS) protons. Unique to synchrocyclotrons is a pulsed proton time
Jufri Setianegara, Hao Gao, Jarrick Nys
exaly   +2 more sources

Hydrated Electron Yield Dependence on Instantaneous Dose Rates With Electron Ultra-High Dose Rate (UHDR) Irradiation

Physics in Medicine and Biology
Objective. The aim of this study was to quantify the characteristic transient production yield of hydrated electrons (G-value) in water under ultra-high dose rates (UHDR) with electron irradiation.
Xu Cao, Brian W Pogue, Wesley S Culberson   +2 more
exaly   +2 more sources

Biological effects of conventional and ultra high dose rate radiation in human cells [PDF]

Scientific Reports
FLASH radiotherapy (FLASH-RT) that uses an ultra-high dose rate (UHDR) radiation is emerging as an effective cancer treatment modality but the biological effects of UHDR are not fully understood.
Terri L. Ryan, Maria B. Escalona, Kelsey O’Brien, Yuewen Tan, Karthik Kanagaraj, Maria Taveras, Leah Nemzow, Michelle Phillippi, Naresh Deoli, Eric Wang, Igor Shuryak, Guy Garty, Helen C. Turner, Adayabalam S. Balajee   +13 more
doaj   +2 more sources

Dosimetric Characterization of a Novel Silicon Carbide Detector With UHDR Proton Beam

Journal of Instrumentation
Radiotherapy (RT) treatments at ultra-high doses (UHDR, >40 Gy/s) can reduce the toxicity induced on healthy tissues while achieving therapeutic goals (in terms of tumor control probability, TCP) that are comparable to those typically attained in ...
Giada Petringa, Roberto Catalano, G A P Cirrone   +2 more
exaly   +2 more sources

Feasibility of Prototype Diamond Detectors for Pulsed UHDR PBS Small-Field Proton Dosimetry for Proton FLASH Experiments

Physics in Medicine and Biology
Objective. This study aims to investigate the responses of prototype diamond detectors under pulsed ultra-high dose rates (UHDRs) pencil-beam-scanning (PBS) protons from a compact proton synchrocyclotron (IBA Proteus®ONE) for small-field UHDR dosimetry ...
Jufri Setianegara, Hao Gao, Jarrick Nys
exaly   +2 more sources

Development and characterization of phantoms to investigate the Flash effect with Drosophila melanogaster at an ultra-high dose rate radiotherapy linac [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Ultra-high dose rate (UHDR) radiotherapy may widen the therapeutic window thanks to the Flash effect. Experimental linear accelerators have been converted to UHDR to collect pre-clinical evidence.
Riccardo Dal Bello, Marvin Kreuzer, Irene Vetrugno, Jamie C. Little, Rafael Kranzer, Stefan Schischke, Lily Bossin, Eduardo Gardenali Yukihara, Matthias Guckenberger, Martin Pruschy, Stephanie Tanadini-Lang   +10 more
doaj   +2 more sources

Systematic Study of Silicon Carbide Detectors and Beam Current Transformer Signals for UHDR Single Electron Pulse Monitoring [PDF]

Radiation Research
The use of ultra-high dose rate beams (UHDR) (> 40 Gy/s) for radiotherapy, despite its advantage of exhibiting the FLASH effect that improves the sparing of healthy tissues, faces challenges in dosimetry and beam monitoring since standard dosimeters like
C. Okpuwe, G. Milluzzo, D. Coves, T. Delaviere, D. Del Sarto, M. De Napoli, F. Di Martino, G. Felici, L. Lanzanò, L. Masturzo, J. Pensavalle, E. Touzain, M. Camarda, F. Romano   +13 more
semanticscholar   +2 more sources

Online Recombination Correction in Dosimetry With Arrays of Ionization Chambers: Application to FFF and UHDR Radiotherapy

Applied Sciences (Switzerland), 2021
Recombination of charge carriers can affect the response of ionization detectors used for the dosimetry of radiotherapy fields. In this work, we present a method for correcting online the recombination effects in arrays of ionization chambers irradiated ...
Juan Pardo-Montero, Faustino Gomez, Jose Paz-Martín   +2 more
exaly   +3 more sources