Results 21 to 30 of about 704 (150)

Examining the Occurrence of the FLASH Effect in Animal Models: A Systematic Review and Meta-Analysis of Ultra-High Dose Rate Proton or Carbon Ion Irradiation

Technology in Cancer Research & Treatment
Purpose: This systematic review and meta-analysis sought to assess whether ultra-high dose rate (UHDR) ion irradiations can induce the FLASH effect in animal models.
Xun Wu MD, Hongtao Luo MD, Qian Wang MD, Tianqi Du MD, Yanliang Chen MD, Mingyu Tan MD, Ruifeng Liu MD, Zhiqiang Liu MR, Shilong Sun MR, Kehu Yang PhD, Jinhui Tian PhD, Qiuning Zhang MD   +11 more
doaj   +2 more sources

Conditional sparing in FLASH radiotherapy: Conformal dosimetry and ALARA remain essential. [PDF]

J Appl Clin Med Phys
Abstract FLASH radiotherapy shows promise in reducing normal tissue toxicity while maintaining tumor control. However, preclinical and early clinical evidence reveal biological and technical uncertainties. We review preclinical and veterinary studies, highlight unexpected toxicities, and argue that the fundamental principles of precision and safety in ...
Chang CC, Ma Y, Kang M, Paliwal B, Morris Z, Durkee B, Cheng C.   +6 more
europepmc   +2 more sources

Review of VHEE Beam Energy Evolution for FLASH Radiation Therapy Under Ultra-High Dose Rate (UHDR) Dosimetry

Quantum Beam Science
Very-high-energy electron (VHEE) beams, ranging from 50 to 300 or 400 MeV, are the subject of intense research investigation, with considerable interest concerning applications in radiation therapy due to their accurate energy deposition into large and ...
Nikolaos Gazis, Evangelos Gazis
doaj   +2 more sources

Time-resolved point dosimetry for spread-out Bragg-peak proton FLASH using fibre-coupled scintillators. [PDF]

Med Phys
Abstract Background In FLASH radiotherapy, the dose is delivered using ultra‐high dose rates (UHDR), which are approximately 100 times higher than those used for conventional (CONV) treatments. This has shown promise in sparing normal tissue while maintaining tumour control.
Steenholdt SR, Johansen JG, Kanouta E, Poulsen PR.   +3 more
europepmc   +2 more sources

Development and validation of a novel pulse optimization and beam control system for conventional and ultra high dose-per-pulse (FLASH) irradiation. [PDF]

Med Phys
Abstract Background FLASH radiotherapy requires precise control and minimal variation of dose per pulse (DPP). However, clinical linear accelerators and their beam control systems are designed to ensure accuracy of the temporally integrated dose and do not control for transient variations in DPP during radiation delivery.
Connell L, Esplen N, Lim R, Baikalov A, Coupey N, Nguyen C, Schüler E.   +6 more
europepmc   +2 more sources

Development of a Real-Time Pixel Array-Type Detector for Ultrahigh Dose-Rate Beams

Sensors, 2023
Although research into ultrahigh dose-rate (UHDR) radiation therapy is ongoing, there is a significant lack of experimental measurements for two-dimensional (2D) dose-rate distributions.
Young Jae Jang, Tae Keun Yang, Jeong Hwan Kim, Hong Suk Jang, Jong Hwi Jeong, Kum Bae Kim, Geun-Beom Kim, Seong Hee Park, Sang Hyoun Choi   +8 more
doaj   +1 more source

First Characterization of Novel Silicon Carbide Detectors with Ultra-High Dose Rate Electron Beams for FLASH Radiotherapy

Applied Sciences, 2023
Ultra-high dose rate (UHDR) beams for FLASH radiotherapy present significant dosimetric challenges. Although novel approaches for decreasing or correcting ion recombination in ionization chambers are being proposed, applicability of ionimetric dosimetry ...
Francesco Romano, Giuliana Milluzzo, Fabio Di Martino, Maria Cristina D’Oca, Giuseppe Felici, Federica Galante, Alessia Gasparini, Giulia Mariani, Maurizio Marrale, Elisabetta Medina, Matteo Pacitti, Enrico Sangregorio, Verdi Vanreusel, Dirk Verellen, Anna Vignati, Massimo Camarda   +15 more
doaj   +1 more source

Ultrahigh-Dose-Rate Proton Irradiation Elicits Reduced Toxicity in Zebrafish Embryos

Advances in Radiation Oncology, 2023
Purpose: Recently, ultrahigh-dose-rate radiation therapy (UHDR-RT) has emerged as a promising strategy to increase the benefit/risk ratio of external RT. Extensive work is on the way to characterize the physical and biological parameters that control the
Gaëlle Saade, Eva Bogaerts, Sophie Chiavassa, PhD, Guillaume Blain, Grégory Delpon, PhD, Manon Evin, Youssef Ghannam, Ferid Haddad, PhD, Karin Haustermans, MD, PhD, Charbel Koumeir, PhD, Ellina Macaeva, PhD, Lydia Maigne, PhD, Quentin Mouchard, PhD, Noël Servagent, PhD, Edmond Sterpin, PhD, Stéphane Supiot, MD, PhD, Vincent Potiron, PhD   +16 more
doaj   +1 more source

Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons

Nuclear Engineering and Technology, 2023
Recently, as the clinically positive biological effects of ultra-high dose rate (UHDR) radiation beams have been revealed, interest in flash radiation therapy has increased. Generally, FLASH preclinical experiments are performed using UHDR electron beams
Hyun Kim, Dong Hyeok Jeong, Sang Koo Kang, Manwoo Lee, Heuijin Lim, Sang Jin Lee, Kyoung Won Jang   +6 more
doaj   +1 more source

A novel fibre optic monitor for VHEE UHDR beam monitoring: first tests at CLEAR

, 2023
Beam monitoring for Ultra High Dose Rate (UHDR) radiation therapy using pulsed beams, i.e. Very High Energy Electrons (VHEE), is a major challenge. The lower pulse repetition of VHEE beams means a larger dose-per-pulse is necessary to achieve the mean ...
Ortega Ruiz, Inaki, Dosanjh, Manjit, Bateman, Joseph, Farabolini, Wilfrid, Corsini, Roberto, Malyzhenkov, Alexander, Korysko, Pierre, Buchanan, Emma, Rieker, Vilde, Gerbershagen, Alexander   +9 more
core   +1 more source