Results 41 to 50 of about 704 (150)
Journal of Synchrotron Radiation, EarlyView.Most cancer patients will be treated by radiotherapy, and recent findings suggest that delivering radiation at `FLASH' ultra‐high dose rates reduces damage to healthy tissues while still damaging the tumour. This project experimentally validates the reduced healthy tissue damage of FLASH radiotherapy on cells using synchrotron‐based beams, which will ...
Moshi Geso +9 more
wiley +1 more source
Physics and Imaging in Radiation Oncology, 2023 Background and purpose: Accurate dosimetry in Ultra-High Dose Rate (UHDR) beams is challenging because high levels of ion recombination occur within ionisation chambers used as reference dosimeters.
John Cotterill +7 more
doaj +1 more source
Modeling for predicting survival fraction of cells after ultra-high dose rate irradiation
, 2023 Objective. FLASH radiotherapy (FLASH-RT) with ultra-high dose rate (UHDR) irradiation (i.e. > 40 Gy s(-1)) spares the function of normal tissues while preserving antitumor efficacy, known as the FLASH effect.
Fukunaga, Hisanori +3 more
core +1 more source
Ultra-high dose rate radiotherapy overcomes radioresistance in head and neck squamous cell carcinoma
Signal Transduction and Targeted TherapyRadiotherapy (RT) resistance in head and neck squamous cell carcinoma (HNSCC) significantly hampers local control and patient prognosis. This study investigated the efficacy and molecular mechanisms of high-energy X-ray-based ultra-high dose rate ...
Hong-Shuai Li +20 more
doaj +1 more source
Macro Monte Carlo dose calculation for very high energy electron (VHEE) radiotherapy
Medical Physics, Volume 53, Issue 7, July 2026.Abstract Background Very high energy electron (VHEE) radiotherapy has gained growing interest owing to its potential to reach deep‐seated targets and induce FLASH effect. Dose calculations can be performed using analytical or Monte Carlo (MC) methods. Analytical approaches enable rapid dose computation but suffer from limited accuracy in heterogeneous ...
Chengchen Zhu +6 more
wiley +1 more source
Systematic Study of Silicon Carbide Detectors and Beam Current Transformer Signals for UHDR Single Electron Pulse Monitoring [PDF]
The use of ultra-high dose rate beams (UHDR) (> 40 Gy/s) for radiotherapy, despite its advantage of exhibiting the FLASH effect that improves the sparing of healthy tissues, faces challenges in dosimetry and beam monitoring since standard dosimeters ...
De Napoli, M. +13 more
core +1 more source
Medical Physics, Volume 53, Issue 7, July 2026.Abstract Background FLASH radiotherapy requires further preclinical and clinical investigation to establish its biological effectiveness and define optimal beam parameters. In conventional (CONV) radiotherapy, redundant beam termination systems are a cornerstone ensuring patient safety, yet analogous safeguards for FLASH delivery are not well ...
Justin DeFrancisco +5 more
wiley +1 more source
, 2023 Objective. This work sets out the capabilities of the high energy proton research beamline developed in the Christie proton therapy centre for Ultra-High Dose Rate (UHDR) irradiation and FLASH experiments.
R I Mackay +15 more
core +1 more source
Applied Sciences, 2023 Charged particle beams driven to ultra-high dose rates (UHDRs) have been shown to offer potential benefits for future clinical applications, particularly in the reduction of normal-tissue toxicity. Studies of the so-called FLASH effect have shown promise,
Sean McCallum +6 more
doaj +1 more source
Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells
Advanced Science, Volume 13, Issue 31, 4 June 2026.This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh +11 more
wiley +1 more source