Results 41 to 50 of about 2,071 (173)

Development of a Real-Time Pixel Array-Type Detector for Ultrahigh Dose-Rate Beams

Sensors, 2023
Although research into ultrahigh dose-rate (UHDR) radiation therapy is ongoing, there is a significant lack of experimental measurements for two-dimensional (2D) dose-rate distributions.
Young Jae Jang, Tae Keun Yang, Jeong Hwan Kim, Hong Suk Jang, Jong Hwi Jeong, Kum Bae Kim, Geun-Beom Kim, Seong Hee Park, Sang Hyoun Choi   +8 more
doaj   +1 more source

Conditional sparing in FLASH radiotherapy: Conformal dosimetry and ALARA remain essential. [PDF]

J Appl Clin Med Phys
Abstract FLASH radiotherapy shows promise in reducing normal tissue toxicity while maintaining tumor control. However, preclinical and early clinical evidence reveal biological and technical uncertainties. We review preclinical and veterinary studies, highlight unexpected toxicities, and argue that the fundamental principles of precision and safety in ...
Chang CC, Ma Y, Kang M, Paliwal B, Morris Z, Durkee B, Cheng C.   +6 more
europepmc   +2 more sources

A multidisciplinary experimental and methodological investigation of electron and proton minibeams in the framework of the INFN MIRO project. [PDF]

Med Phys
Abstract Background The clinical translation of Minibeam RT (MBRT) has recently started thanks to the first human treatments recently performed. However, despite experimental evidence, the impact of the dose distribution parameters involved on the magnitude of the effect itself and the underlying radiobiological mechanisms are still only partially ...
Romano F, Zanacchi FC, Ciarrocchi E, Franciosini G, Milluzzo G, Scifoni E, Vignati A, Ahmad S, Arezzini S, Attili A, Battestini M, Bernardini J, Bettanin M, Bisio A, Bisogni MG, Bodrenko I, Bordieri G, Bravatà V, Burattini A, Camarda M, Cammarata FP, Capaccioli S, Castelli L, Cavalieri A, Celentano M, Chiadroni E, Cordoni FG, Corvaia E, Costa M, Curcio A, Da Pozzo E, De Felice M, Debbio FD, D'Errico F, D'Oca MC, D'Orsi B, Deut U, Durisi E, Fantacci ME, Farina S, Felici G, Ferro A, Ficcadenti L, Formuso A, Forte GI, Giordanengo S, Giuliano A, Giuliano L, Lanzanò L, Linsalata S, Lossano S, Maffei M, Marafini M, Marrale M, Massa M, Masturzo L, Mazzoni E, Migliorati M, Milian FM, Minafra L, Moggi A, Olivares DM, Montefiori M, Morrocchi M, Mostacci A, Mostardi F, Okpuwe C, Paiar F, Palumbo L, Patera V, Pensavalle JH, Pucci G, Quattrini F, Retico A, Rosso V, Russo G, Sacchi R, Sarti A, Scalisi S, Scapicchio C, Schiavi A, Stochino P, Strettoi E, Tommasino F, Tozzini V, Traini G, Trovato G, Usai A, Urso F, Martino FD.   +89 more
europepmc   +2 more sources

Effect of oxygen and nanoparticles on human skin and colon cells exposed to synchrotron-based X-ray FLASH beams. [PDF]

J Synchrotron Radiat
Most cancer patients will be treated by radiotherapy, and recent findings suggest that delivering radiation at `FLASH' ultra‐high dose rates reduces damage to healthy tissues while still damaging the tumour. This project experimentally validates the reduced healthy tissue damage of FLASH radiotherapy on cells using synchrotron‐based beams, which will ...
Geso M, Cameron M, Ffrench T, Forrester H, Lynch R, Nakayama M, Patterson W, Rahman WN, Butler D, Piva TJ.   +9 more
europepmc   +2 more sources

A novel fibre optic monitor for VHEE UHDR beam monitoring: first tests at CLEAR

, 2023
Beam monitoring for Ultra High Dose Rate (UHDR) radiation therapy using pulsed beams, i.e. Very High Energy Electrons (VHEE), is a major challenge. The lower pulse repetition of VHEE beams means a larger dose-per-pulse is necessary to achieve the mean ...
Ortega Ruiz, Inaki, Dosanjh, Manjit, Bateman, Joseph, Farabolini, Wilfrid, Corsini, Roberto, Malyzhenkov, Alexander, Korysko, Pierre, Buchanan, Emma, Rieker, Vilde, Gerbershagen, Alexander   +9 more
core   +1 more source

Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons

Nuclear Engineering and Technology, 2023
Recently, as the clinically positive biological effects of ultra-high dose rate (UHDR) radiation beams have been revealed, interest in flash radiation therapy has increased. Generally, FLASH preclinical experiments are performed using UHDR electron beams
Hyun Kim, Dong Hyeok Jeong, Sang Koo Kang, Manwoo Lee, Heuijin Lim, Sang Jin Lee, Kyoung Won Jang   +6 more
doaj   +1 more source

Design of an ultra-high dose rate cell irradiation experimental platform using a medical proton linear injector

He jishu, 2023
BackgroundUltra-high dose rate (UHDR) radiation of electron or proton beam has been shown to spare normal tissues surrounding the tumors while killing tumor cells effectively which is called the FLASH effect (FE).
LIU Junya, YU Xiao, WU Chao, SUN Xiangshang, SHANG Haijiao, LIAO Wentao, YAN Nan, ZHOU Yun, PU Yuehu   +8 more
doaj   +1 more source

Linear mixed effects models for RNFL-G thickness, RNFL-T thickness, and macular volume in the Huntington’s disease group with UHDR TMS and disease duration as fixed effects.

, 2023
Linear mixed effects models for RNFL-G thickness, RNFL-T thickness, and macular volume in the Huntington’s disease group with UHDR TMS and disease duration as fixed effects.
Olga Ulmanova (14675370), Jiri Klempir (13227643), Ales Kopal (14675367), Jana Lizrova Preiningerova (14675373), Jan Roth (419817), Michaela Brichova (10750969), Pavel Dusek (14675364)   +6 more
core   +1 more source

First evidence of in vivo effect of FLASH radiotherapy with helium ions in zebrafish embryos

, 2023
International audienceThe ability to reduce toxicity of ultra-high dose rate (UHDR) helium ion irradiation has not been reported in vivo. Here, we tested UHDR helium ion irradiation in an embryonic zebrafish model.
Guillaume Blain, Lydia Maigne, Evin, Manon, Gaëlle Saade, Stéphane Supiot, Vincent Potiron, Youssef Ghannam, Sophie Chiavassa, Ghannam, Youssef, Haddad, Ferid, Blain, Guillaume, Supiot, Stéphane, Mouchard, Quentin, Koumeir, Charbel, Servagent, Noël, Potiron, Vincent, Manon Evin, Quentin Mouchard, Saade, Gaëlle, Charbel Koumeir, Grégory Delpon, Chiavassa, Sophie, Maigne, Lydia, Delpon, Grégory, Ferid Haddad, Noël Servagent   +25 more
core   +1 more source

Evaluation and Applicability of Radiation Detectors for Quantitative Assessment of Radiation Exposure in a 16-MeV Electron UHDR Linac

Radiation Measurements
Stephanie Tanadini-Lang, Eduardo G Yukihara, Matthias Guckenberger   +2 more
exaly   +2 more sources