Results 51 to 60 of about 2,071 (173)

A mechanistic‐based normal tissue complication probability (NTCP) prediction through a microdosimetry‐based multiscale radiation biophysical model (MS‐GSM2) [PDF]

Precis Radiat Oncol
Precision Radiation Oncology, EarlyView.
Battestini M, Missiaggia M, Bordieri G, Morand J, Scifoni E, Cordoni F.   +5 more
europepmc   +2 more sources

Proton and electron UHDR isodose irradiations produce differences in reactive oxygen species yields

International Journal of Radiation Oncology, Biology, Physics, 2023
Purpose: Investigations into ultra-high dose rate (UHDR) radiotherapy have dramatically risen because of the observed normal tissue sparing FLASH effect without sacrificing tumor control.
William S. Thomas, J. Sunnerberg, M. Reed, D. Gladstone, Rong-Xiao Zhang, J. Harms, H. Swartz, B. Pogue   +7 more
semanticscholar   +1 more source

Enabling ultra-high dose rate electron beams at a clinical linear accelerator for isocentric treatments [PDF]

, 2023
BACKGROUND AND PURPOSE Radiotherapy delivery with ultra-high dose rates (UHDR) has consistently produced normal tissue sparing while maintaining efficacy for tumour control in preclinical studies, known as the FLASH effect.
Saltybaeva, Natalia, Ahmed, Md, Tanadini-Lang, Stephanie, Stephanie Tanadini-Lang, von der Grün, Jens, Fabiano, Silvia, Thomas Rudolf, Jens von der Grün, Serpil Kucuker Dogan, Kucuker Dogan, Serpil, Dal Bello, Riccardo, Guckenberger, Matthias, S Stark, Luisa, Bathula, Manohar, Luisa S. Stark, Joshua McNeur, Matthias Guckenberger, Md Ahmed, Natalia Saltybaeva, Manohar Bathula, Rudolf, Thomas, Riccardo Dal Bello, Silvia Fabiano, McNeur, Joshua   +23 more
core   +1 more source

Modeling for predicting survival fraction of cells after ultra-high dose rate irradiation

, 2023
Objective. FLASH radiotherapy (FLASH-RT) with ultra-high dose rate (UHDR) irradiation (i.e. > 40 Gy s(-1)) spares the function of normal tissues while preserving antitumor efficacy, known as the FLASH effect.
Fukunaga, Hisanori, Matsuya, Yusuke, Kusumoto, Tamon, Shiraishi, Yuta   +3 more
core   +1 more source

Ultra‐high dose rate radiation production and delivery systems intended for FLASH [PDF]

, 2022
Higher dose rates, a trend for radiotherapy machines, can be beneficial in shortening treatment times for radiosurgery and mitigating the effects of motion.
Farr, J., Victor Malka, Veljko Grilj, Grilj, V., Grilj, Veljko, Sudharsan, Srinivasan, Srinivasan Sudharsan, Malka, Victor, Farr, Jonathan, Malka, V., Jonathan Farr, Schippers, Marco, Sudharsan, S., Schippers, M., Marco Schippers, Farr, Jonathan (author), Malka, Victor (author), Sudharsan, Srinivasan (author), Grilj, Veljko (author), Schippers, Marco (author)   +19 more
core   +1 more source

Absolute dosimetry for FLASH proton pencil beam scanning radiotherapy

Scientific Reports, 2023
A paradigm shift is occurring in clinical oncology exploiting the recent discovery that short pulses of ultra-high dose rate (UHDR) radiation—FLASH radiotherapy—can significantly spare healthy tissues whilst still being at least as effective in curing ...
Ana Lourenço, Anna Subiel, Nigel Lee, Sam Flynn, John Cotterill, David Shipley, Francesco Romano, Joe Speth, Eunsin Lee, Yongbin Zhang, Zhiyan Xiao, Anthony Mascia, Richard A. Amos, Hugo Palmans, Russell Thomas   +14 more
doaj   +1 more source

Breathe, Eat, Talk: Three Essential Ingredients to Quality‐of‐Life Outcomes in Movement Disorders

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Breathing, eating, and talking (BET) impairments are common yet frequently underrecognized features of movement disorders. Deficits in respiration, swallowing, voice, and speech may emerge early in the course of a disease, adversely affecting safety, participation, and quality of life.
John Dean, Lena C. O’Flynn, Michelle Ciucci, Cynthia Fox, Jessica E. Huber, Supraja Anand, Maira Rozenfeld Olchik, Jibrin S. Usman, Adam P. Vogel, Bettina Aguiar, Diana Khasanova, Dharshini Manoharan, Lorraine Ramig, Angela Roberts, Federico Rodriguez‐Porcel, Kristina Simonyan, Julie M. Barkmeier‐Kraemer   +16 more
wiley   +1 more source

Quantitative real-time measurements of dose and dose rate in UHDR proton pencil beams via scintillation imaging system [PDF]

, 2023
Purpose: Ultra-fast scintillation imaging has been shown to provide a unique tool for spatio-temporal dosimetry of conventional cyclotron and synchrocyclotron pencil beam scanning (PBS) deliveries, indicating the potential use for characterization of ...
Zhang, Rongxiao, Simon, Bill, Harms, Joseph, Vasyltsiv, Roman, Gladstone, David, Bruza, Petr, Clark, Megan, Kozelka, Jakub, Sloop, Austin   +8 more
core  

Radiobiology experiments with a laser driven x-ray source: Exploring the UHDR regime

, 2023
Laser Driven Plasma Accelerators (LDPA) can generate both characteristic and Bremsstrahlung x-rays in ultrashort bunches. Because of the high intensity of the laser pulses, these laser-induced x-ray sources can achieve peak dose rates compatible with the
A. Alejo, A. Reija, A. Vega, C. Ruiz, R. Contreras-Martínez, J. Juan, M.E. Aguado-Barrera, M. Seimetz, J. Benlliure, J. Peñas, A. Bembibre, A. Coathup, F. Barranco   +12 more
core   +1 more source

HD‐DRUM Rhythmic Training in Huntington's Disease: Feasibility, Motor, and Brain Microstructural Pilot Signals

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Rhythmic cuing may benefit motor functions in Huntington's disease (HD) by compensating for the loss of predictive timing associated with basal ganglia degeneration. To our knowledge no remote rhythmic training application has been developed or evaluated that seeks to improve function in HD.
Pedro Luque Laguna, Vasileios Ioakeimidis, Cheney J.G. Drew, Philip Pallmann, Monica Busse‐Morris, Guy B. Watson, Robin Schubert, Anne E. Rosser, Claudia Metzler‐Baddeley   +8 more
wiley   +1 more source