Results 71 to 80 of about 704 (150)

Changes in scanning orientation effects of Gafchromic EBT-3 film irradiated with ultra-high dose rate proton beams

Discover Applied Sciences
While the FLASH radiotherapy (FLASH RT) using ultra-high-dose-rate (UHDR) proton beams has the potential to achieve more effective cancer treatment, reliable and practical dosimetry of UHDR beams remains challenging.
Hiroshi Yasuda, Hassna Bantan, Masumi Umezawa, Masashi Yamada, Katsunori Yogo, Toshiyuki Toshito   +5 more
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Characterization of a Modified Clinical Linear Accelerator for Ultra-High Dose Rate Beam Delivery

Applied Sciences
Irradiations at Ultra-High Dose Rate (UHDR) regimes, exceeding 40 Gy/s in single fractions lasting less than 200 ms, have shown an equivalent antitumor effect compared to conventional radiotherapy with reduced harm to normal tissues.
Umberto Deut, Aurora Camperi, Cristiano Cavicchi, Roberto Cirio, Emanuele Maria Data, Elisabetta Alessandra Durisi, Veronica Ferrero, Arianna Ferro, Simona Giordanengo, Oscar Martì Villarreal, Felix Mas Milian, Elisabetta Medina, Diango M. Montalvan Olivares, Franco Mostardi, Valeria Monti, Roberto Sacchi, Edoardo Salmeri, Anna Vignati   +17 more
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Commissioning a clinical proton pencil beam scanning beamline for pre-clinical ultra-high dose rate irradiations on a cyclotron-based system

Frontiers in Oncology
BackgroundThis manuscript describes modifications to a pencil beam scanning (PBS) proton gantry that enables ultra-high dose rates (UHDR) irradiation, including treatment planning and validation.MethodsBeamline modifications consisted of opening the ...
Jatinder Saini, Jatinder Saini, Danielle P. Johnson Erickson, François Vander Stappen, Matt Ruth, Matt Ruth, Sunan Cui, Sunan Cui, Vanessa Gorman, Séverine Rossomme, Ning Cao, Ning Cao, Eric C. Ford, Eric C. Ford, Juergen Meyer, Juergen Meyer, Charles Bloch, Charles Bloch, Tony Wong, Tony Wong, Clemens Grassberger, Ramesh Rengan, Ramesh Rengan, Jing Zeng, Jing Zeng, Marco Schwarz, Marco Schwarz   +26 more
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VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint

Scientific Reports
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied across several radiation modalities, including photons, protons and clinical energy electrons ...
Hannah C. Wanstall, Pierre Korysko, Wilfred Farabolini, Roberto Corsini, Joseph J. Bateman, Vilde Rieker, Abigail Hemming, Nicholas T. Henthorn, Michael J. Merchant, Elham Santina, Amy L. Chadwick, Cameron Robertson, Alexander Malyzhenkov, Roger M. Jones   +13 more
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Luminescence imaging of water irradiated by protons under FLASH radiation therapy conditions

, 2023
Objective. FLASH radiation therapy with ultrahigh dose rates (UHDR) has the potential to reduce damage to normal tissue while maintaining anti-tumor efficacy.
Masashi Yamada, Takuto Miyoshi, Toshiyuki Toshito, Jun Kataoka, Kitamura Hisashi, Kodaira Satoshi, Kusumoto Tamon, Hiroshi Yasuda, Seiichi Yamamoto, Katsunori Yogo, Masumi Umezawa, Hiromitsu Iwata, Masataka Komori   +12 more
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Beam control system and output fine-tuning for safe and precise delivery of FLASH radiotherapy at a clinical linear accelerator

Frontiers in Oncology
IntroductionWe have previously adapted a clinical linear accelerator (Elekta Precise, Elekta AB) for ultra-high dose rate (UHDR) electron delivery.
Elise Konradsson, Pontus Wahlqvist, Andreas Thoft, Börje Blad, Börje Blad, Sven Bäck, Sven Bäck, Crister Ceberg, Kristoffer Petersson, Kristoffer Petersson   +9 more
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Solid-State Detector for FLASH Radiotherapy: Dosimetric Applications and Emerging Concepts

Condensed Matter
The implementation of FLASH Radiotherapy (FLASH-RT), characterized by ultra-high dose rates (UHDRs) frequently exceeding 106 Gy/s in microsecond pulses, imposes stringent requirements on real-time dosimetry. Conventional ionization chambers suffer severe
Pablo P. Yepes
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Instantaneous dose rate as a crucial factor in reducing mortality and normal tissue toxicities in murine total-body irradiation: a comparative study of dose rate combinations

Molecular Medicine
Purpose The ultra-high dose rate (UHDR) radiation shows promise in eradicating tumors while reducing normal tissue toxicities. However, the biological outcomes of UHDR are influenced by various factors, particularly the mean dose rate and instantaneous ...
Hongyu Zhu, Shihua Liu, Jiaqi Qiu, Ankang Hu, Wanyi Zhou, Jian Wang, Weihang Gu, Yinuo Zhu, Hao Zha, Rong Xiang, Junli Li, Rui Qiu, Chong Zhao, Peng Huang, Xiaowu Deng   +14 more
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First-in-human e-Flash radiotherapy using a modified conventional C-arm linear accelerator

Clinical and Translational Radiation Oncology
Background: The FLASH effect is considered being the widening of the therapeutic window at (ultra-)high dose rates due to sparing of normal tissues while preserving tumor response.
Jens von der Grün, Riccardo Dal Bello, Serena Psoroulas, Jerome Krayenbuehl, Debra Fesslmeier, Egle Ramelyte, Joanna Mangana, Wendy Smith, Marta Vilalta, Lena Tirpak, Ricky A. Sharma, Matthias Guckenberger, Stephanie Tanadini-Lang, Panagiotis Balermpas   +13 more
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Standard requirements for clinical very high energy electron and ultra high dose rate medical devices

Frontiers in Physics
Very High-Energy Electrons (VHEE) present a promising innovation in radiation therapy (RT), particularly for the treatment of deep-seated tumors using Ultra High Dose Rate (UHDR) within the framework of FLASH-RT.
J. H. Pensavalle, F. Di Martino, F. Di Martino, F. Di Martino, A. Cavalieri, M. Celentano, M. Celentano, A. De Gregorio, A. De Gregorio, M. Di Francesco, G. Franciosini, G. Franciosini, L. Galluzzo, L. Masturzo, L. Masturzo, G. Milluzzo, P. Montay-Gruel, P. Montay-Gruel, F. Paiar, F. Paiar, F. Paiar, M. Pantaleoni, V. Patera, V. Patera, S. Pioli, P. Poortmans, P. Poortmans, F. Romano, F. Romano, A. Sarti, A. Sarti, A. Subiel, A. Subiel, A. Vannozzi, G. Felici   +34 more
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