Results 81 to 90 of about 2,071 (173)

Review of VHEE Beam Energy Evolution for FLASH Radiation Therapy Under Ultra-High Dose Rate (UHDR) Dosimetry

Quantum Beam Science
Very-high-energy electron (VHEE) beams, ranging from 50 to 300 or 400 MeV, are the subject of intense research investigation, with considerable interest concerning applications in radiation therapy due to their accurate energy deposition into large and ...
Nikolaos Gazis, E. Gazis
semanticscholar   +1 more source

Macro Monte Carlo dose calculation for very high energy electron (VHEE) radiotherapy

Medical Physics, Volume 53, Issue 7, July 2026.
Abstract Background Very high energy electron (VHEE) radiotherapy has gained growing interest owing to its potential to reach deep‐seated targets and induce FLASH effect. Dose calculations can be performed using analytical or Monte Carlo (MC) methods. Analytical approaches enable rapid dose computation but suffer from limited accuracy in heterogeneous ...
Chengchen Zhu, Florian Amstutz, Claire M. Costantini, Werner Volken, Marco F. M. Stampanoni, Peter Manser, Michael K. Fix   +6 more
wiley   +1 more source

Development and evaluation of an in vivo dose‐based monitoring system for electron FLASH radiation therapy

Medical Physics, Volume 53, Issue 7, July 2026.
Abstract Background FLASH radiotherapy requires further preclinical and clinical investigation to establish its biological effectiveness and define optimal beam parameters. In conventional (CONV) radiotherapy, redundant beam termination systems are a cornerstone ensuring patient safety, yet analogous safeguards for FLASH delivery are not well ...
Justin DeFrancisco, Matthew Richeson, Tomaj Javidtash, Chris Bartee, Tianjun Ma, Siyong Kim   +5 more
wiley   +1 more source

Examining the Occurrence of the FLASH Effect in Animal Models: A Systematic Review and Meta-Analysis of Ultra-High Dose Rate Proton or Carbon Ion Irradiation

Technology in Cancer Research & Treatment
Purpose: This systematic review and meta-analysis sought to assess whether ultra-high dose rate (UHDR) ion irradiations can induce the FLASH effect in animal models.
Xun Wu MD, Hongtao Luo MD, Qian Wang MD, Tianqi Du MD, Yanliang Chen MD, Mingyu Tan MD, Ruifeng Liu MD, Zhiqiang Liu MR, Shilong Sun MR, Kehu Yang PhD, Jinhui Tian PhD, Qiuning Zhang MD   +11 more
doaj   +1 more source

Anesthetic Oxygen Use and Sex Are Critical Factors in the FLASH Sparing Effect

Advances in Radiation Oncology
Purpose: Ultra High Dose-Rate (UHDR) radiation has been reported to spare normal tissue, compared with Conventional Dose-Rate (CDR) radiation. However, important work remains to be done to improve the reproducibility of the FLASH effect.
Armin D. Tavakkoli, BA, Megan A. Clark, BE, Alireza Kheirollah, PhD, Austin M. Sloop, MS, Haille E. Soderholm, BA, Noah J. Daniel, MS, Arthur F. Petusseau, PhD, Yina H. Huang, PhD, Charles R. Thomas, Jr, MD, Lesley A. Jarvis, MD, PhD, Rongxiao Zhang, PhD, Brian W. Pogue, PhD, David J. Gladstone, ScD, P. Jack Hoopes, DVM, PhD   +13 more
doaj   +1 more source

First experimental validation of silicon-based sensors for monitoring ultra-high dose rate electron beams

Frontiers in Physics
Monitoring Ultra-High Dose Rate (UHDR) beams is one of the multiple challenges posed by the emergent FLASH radiotherapy. Technologies (i.e., gas-filled ionization chambers) nowadays used in conventional radiotherapy are no longer effective when applied ...
Elisabetta Medina, Elisabetta Medina, Arianna Ferro, Arianna Ferro, Mohammad Abujami, Mohammad Abujami, Aurora Camperi, Matteo Centis Vignali, Emanuele Data, Emanuele Data, Damiano Del Sarto, Damiano Del Sarto, Umberto Deut, Umberto Deut, Fabio Di Martino, Fabio Di Martino, Fabio Di Martino, Mohammad Fadavi Mazinani, Marco Ferrero, Veronica Ferrero, Simona Giordanengo, Oscar A. Martì Villarreal, Mohammad Amin Hosseini, Mohammad Amin Hosseini, Felix Mas Milian, Felix Mas Milian, Luigi Masturzo, Luigi Masturzo, Luigi Masturzo, Luigi Masturzo, Diango M. Montalvan Olivares, Diango M. Montalvan Olivares, Marco Montefiori, Marco Montefiori, Giovanni Paternoster, Jake Harold Pensavalle, Jake Harold Pensavalle, Jake Harold Pensavalle, Jake Harold Pensavalle, Valentina Sola, Valentina Sola, Roberto Cirio, Roberto Cirio, Roberto Sacchi, Roberto Sacchi, Anna Vignati, Anna Vignati   +46 more
doaj   +1 more source

Changes in scanning orientation effects of Gafchromic EBT-3 film irradiated with ultra-high dose rate proton beams

Discover Applied Sciences
While the FLASH radiotherapy (FLASH RT) using ultra-high-dose-rate (UHDR) proton beams has the potential to achieve more effective cancer treatment, reliable and practical dosimetry of UHDR beams remains challenging.
Hiroshi Yasuda, Hassna Bantan, Masumi Umezawa, Masashi Yamada, Katsunori Yogo, Toshiyuki Toshito   +5 more
doaj   +1 more source

Reactive Oxygen Species Yield near Gold Nanoparticles Under Ultrahigh-Dose-Rate Electron Beams: A Monte Carlo Study

Nanomaterials
Ultrahigh dose rate (UHDR) radiotherapy, also known as FLASH radiotherapy (FLASH-RT), has shown potential for increasing tumor control while sparing normal tissue.
Chloe Doen Kim, James C. L. Chow
doaj   +1 more source

Technical note: Dosimetry and FLASH potential of UHDR proton PBS for small lung tumors: Bragg‐peak‐based delivery versus transmission beam and IMPT

Medical Physics (Lancaster)
High‐energy transmission beams (TBs) are currently the main delivery method for proton pencil beam scanning ultrahigh dose‐rate (UHDR) FLASH radiotherapy.
P. van Marlen, S. van de Water, B. Slotman, M. Dahele, W. Verbakel   +4 more
semanticscholar   +1 more source

Technical note: Validation of an ultrahigh dose rate pulsed electron beam monitoring system using a current transformer for FLASH preclinical studies

, 2021
PURPOSE: The Oriatron eRT6 is a linear accelerator (linac) used in FLASH preclinical studies able to reach dose rates ranging from conventional (CONV) up to ultrahigh (UHDR).
Moeckli, R., Patrik Gonçalves Jorge, Jean-François Germond, Bochud, François, Bochud, F., Raphaël Moeckli, Moeckli, Raphaël, Jean Bourhis, Germond, Jean‐François, Bailat, Claude, Bourhis, J., Gonçalves Jorge, Patrik, Bourhis, Jean, Jean‐François Germond, Claude Bailat, Vozenin, M.C., Bailat, C., Gonçalves Jorge, P., Veljko Grilj, Vozenin, Marie‐Catherine, François Bochud, Grilj, V., Germond, J.F., Grilj, Veljko, Marie-Catherine Vozenin, Marie‐Catherine Vozenin   +25 more
core   +1 more source