Results 101 to 110 of about 2,071 (173)

Anesthesia is a potent determinant of ultra-high dose rate sparing in the murine total abdominal irradiation model

Frontiers in Oncology
IntroductionRadiation therapy is a mainstay of treatment for numerous gastrointestinal (GI) malignancies, where our ability to deliver dose to tumors is limited by acute GI toxicity. Ultra-high dose-rate (UHDR) ‘FLASH’ irradiation can spare normal tissue,
Armin D. Tavakkoli, Armin D. Tavakkoli, William W. Daley, David I Hunter, Beverly A. Allen, Gretchen C. Carpenter, David J. Gladstone, Brian W. Pogue, P. Jack Hoopes, P. Jack Hoopes   +9 more
doaj   +1 more source

Breathing-phase selection for gated proton therapy in lung cancer towards temporally targeted ultra-high dose rate delivery

Physics and Imaging in Radiation Oncology
Background and purpose: Ultra-high dose rate (UHDR) irradiation has been demonstrated to reduce normal tissue damage compared to conventional dose rates, while maintaining tumor response (FLASH-effect).
Simone N. Visser, Krista C.J. van Doorn-Wink, Koen F. Crama, Coen R.N. Rasch, Steven J.M. Habraken   +4 more
doaj   +1 more source

Instantaneous dose rate as a crucial factor in reducing mortality and normal tissue toxicities in murine total-body irradiation: a comparative study of dose rate combinations

Molecular Medicine
Purpose The ultra-high dose rate (UHDR) radiation shows promise in eradicating tumors while reducing normal tissue toxicities. However, the biological outcomes of UHDR are influenced by various factors, particularly the mean dose rate and instantaneous ...
Hongyu Zhu, Shihua Liu, Jiaqi Qiu, Ankang Hu, Wanyi Zhou, Jian Wang, Weihang Gu, Yinuo Zhu, Hao Zha, Rong Xiang, Junli Li, Rui Qiu, Chong Zhao, Peng Huang, Xiaowu Deng   +14 more
doaj   +1 more source

Changes in Yields of Water Radiolysis Species and Strand Breaks of Pbr322 Plasmid DNA under Ultra-high Dose Rate C Ions: Towards the Elucidation of the Mechanism of FLASH Radiotherapy

To clarify the mechanisms of FLASH radiotherapy using C ion beams (373 MeV/u and 90 MeV/u), we investigated the dose rate dependence of yields of water radiolysis species (OH radicals, hydrated electrons, and hydrogen peroxide).
Kazuyoshi Kurita, Koki Kasamatsu, Teruaki Konishi, Taisei Mamiya, Satoshi Kodaira, Tamon Kusumoto, Taku Inaniwa   +6 more
core   +1 more source

Platinum Nanoparticle Radioenhancement is Preserved Under FLASH Very High-Energy Electron Irradiation: An in vitro Tumor Spheroid Study

International Journal of Nanomedicine
Foutina Feghali,1 Pauline Maury,2,3 Cathyanne Schott,3 Pierre Korysko,4,5 Antonio Gilardi,4 Giacomo Tangari,4,6 Wilfrid Farabolini,4 Jonathan Ollivier,7 Marie-Catherine Vozenin,7 Roberto Corsini,4 Sandrine Lacombe,1 Erika Porcel11Institut des Sciences ...
Feghali F, Maury P, Schott C, Korysko P, Gilardi A, Tangari G, Farabolini W, Ollivier J, Vozenin MC, Corsini R, Lacombe S, Porcel E   +11 more
doaj  

First-in-human e-Flash radiotherapy using a modified conventional C-arm linear accelerator

Clinical and Translational Radiation Oncology
Background: The FLASH effect is considered being the widening of the therapeutic window at (ultra-)high dose rates due to sparing of normal tissues while preserving tumor response.
Jens von der Grün, Riccardo Dal Bello, Serena Psoroulas, Jerome Krayenbuehl, Debra Fesslmeier, Egle Ramelyte, Joanna Mangana, Wendy Smith, Marta Vilalta, Lena Tirpak, Ricky A. Sharma, Matthias Guckenberger, Stephanie Tanadini-Lang, Panagiotis Balermpas   +13 more
doaj   +1 more source

Design and performance evaluation of a novel hybrid ionisation chamber and transmission calorimeter for dose rate independent beam monitoring in UHDR-RT

Background. Ultra-High Dose Rate Radiotherapy (UHDR-RT) is an emerging cancer treatment that delivers radiation at dose rates exceeding 40 Gy/s. While UHDR-RT offers potential therapeutic benefits, accurate dosimetry presents significant challenges ...
Thomas, Russell, Tullis, Iain, Bass, Graham, Petersson, Kristoffer, Subiel, Anna, Lee, Nigel, Flynn, Samuel, Habgood, Rebecca, Subiel, Anna,, Flynn, Samuel,, Petersson, Kristoffer,, Thomas, Russell,, Tullis, Iain,, Lee, Nigel,, Habgood, Rebecca,, Lund University., Bass, Graham,   +16 more
core   +1 more source

Standard requirements for clinical very high energy electron and ultra high dose rate medical devices

Frontiers in Physics
Very High-Energy Electrons (VHEE) present a promising innovation in radiation therapy (RT), particularly for the treatment of deep-seated tumors using Ultra High Dose Rate (UHDR) within the framework of FLASH-RT.
J. H. Pensavalle, F. Di Martino, F. Di Martino, F. Di Martino, A. Cavalieri, M. Celentano, M. Celentano, A. De Gregorio, A. De Gregorio, M. Di Francesco, G. Franciosini, G. Franciosini, L. Galluzzo, L. Masturzo, L. Masturzo, G. Milluzzo, P. Montay-Gruel, P. Montay-Gruel, F. Paiar, F. Paiar, F. Paiar, M. Pantaleoni, V. Patera, V. Patera, S. Pioli, P. Poortmans, P. Poortmans, F. Romano, F. Romano, A. Sarti, A. Sarti, A. Subiel, A. Subiel, A. Vannozzi, G. Felici   +34 more
doaj   +1 more source

Simulation and validation of scatter radiation measurements in Ultra High Dose Rate (UHDR) irradiations

Ultra-High Dose Rate (UHDR)-radiotherapie , bekend om het verminderen van schade aan gezond weefsel via het FLASH-effect, brengt verschillende uitdagingen met zich mee op het gebied van dosimetrie en stralingsbescherming.
Vandeweyer, Jelle
core  

Commissioning an Ultra-High-Dose-Rate Electron Linac With End-To-End Tests

Objective. The FLASH effect can potentially be used to improve the therapeutic ratio of radiotherapy (RT) through delivery of Ultra-high-dose-rate (UHDR) irradiation.
Zhang, Rongxiao, Ashraf, Muhammad R., Ashraf, Muhammad R, Bruza, Petr, Pogue, Brian W, Pogue, Brian W., Clark, Megan A., Jarvis, Lesley, Gladstone, David J, Sunnerberg, Jacob P., Sloop, Austin M, Sloop, Austin M., Sunnerberg, Jacob P, Dai, Tianyuan, Clark, Megan A, Gladstone, David J.   +15 more
core   +1 more source