Results 111 to 120 of about 2,071 (173)

Impact of Ultra-High-Dose-Rate Irradiation on DNA: Single-Strand Breaks and Base Damage

Studying different types of DNA damage induced by ultra-high-dose-rate (UHDR) irradiation is essential for understanding the mechanism underlying the FLASH effect. pBR322 plasmid DNA was irradiated using an electron FLASH beam.
Qibin Fu, Yan Zhang, Yucheng Wang, Tuchen Huang, Chenyang Huang   +4 more
core   +1 more source

Investigating the Influence of Conventional vs. Ultra-High Dose Rate Proton Irradiation Under Normoxic or Hypoxic Conditions on Multiple Developmental Endpoints in Zebrafish Embryos

Objectives: To investigate how the FLASH effect modulates radiation response on multiple developmental endpoints of zebrafish embryos under normoxic and hypoxic conditions, after irradiation with proton beams at a conventional and an ultra-high dose rate
Alberto Fasolini, Maria Caterina Mione, Francesco Tommasino, Alessia Faggian, Sara Citter, Giorgio Russo, Gaia Pucci, Stefano Lorentini, Marco Calvaruso, Emanuele Scifoni, Alessandra Bisio, Enrico Verroi, Giusi Irma Forte   +12 more
core   +1 more source

Integration von Physik, Chemie und Biologie zur mechanistischen Aufklärung und klinischen Umsetzung der FLASH-Strahlentherapie mit ultrahoher Dosisrate

A novel radiation therapy (RT) modality, FLASH-RT, reduces normal tissue toxicity while maintaining tumor control by using ultra-high dose rates (UHDRs).
Baikalov, Alexander Robert
core  

The FLASH Effect in 3D and 2D Models:Preserving Tumor Control while Reducing Apoptosis in Normal Cells

Irradiation at ultra-high dose rates is gaining increased attention due to its ability to limit damage to surrounding healthy tissues, thereby preventing radiation-induced side effects.
Koumeir, Charbel, Scarmelotto, Andrea, Heuskin, Anne-Catherine; id_orcid, Lucas, Stéphane, Lambert, Emma; id_orcid, Delprat, Victor, Michiels, Carine   +6 more
core   +1 more source

Physicochemical modeling of electron FLASH to identify the roles of oxygen, aqueous electrons and causal radical recombination effects underlying them. [PDF]

Phys Med Biol
Thomas WS, Cao X, Gladstone DJ, Swartz HM, Pogue BW.   +4 more
europepmc   +1 more source

BK_Ca channel deletion modulates the DNA damage response to electron ultra-high dose rate irradiation in glioblastoma cells. [PDF]

J Neurooncol
Maliszewska-Olejniczak K, Fryc M, Kustra A, Wiktorska K, Lenartowicz-Gasik A, Soroka W, Rzadkiewicz J, Żochowska M, Kulawiak B, Bednarczyk P.   +9 more
europepmc   +1 more source

STAR in a Second: Ultra-High-Dose-Rate Spread-Out Bragg Peak Proton Therapy for Breath-Hold Stereotactic Arrhythmia Radioablation. [PDF]

Adv Radiat Oncol
Ramesh P, Schwarz M, Colbert C, Chen XC, Panjwani N, Bowen SR, Grassberger C, Wei C, Batnyam U, Nazer B, Nyflot MJ.   +10 more
europepmc   +1 more source

Toxicité de la hadronthérapie à ultra-haut débit de dose

Ultra-High Dose Rate Radiotherapy (UHDR-RT), on the order of Gray/msec, is a promising technique for reducing toxicity to healthy tissues. Furthermore, the ballistic properties of hadrons (protons/helium ions) allow better tumor targeting and reduced ...
Saade, Gaëlle
core   +1 more source

FLASH radiotherapy: physico-chemical considerations on ionisation tracks, radical reactions, and the role of oxygen. [PDF]

Radiat Oncol
Herskind C, O'Neill P, Horsman MR.
europepmc   +1 more source

TOPAS-nBio simulation of the impact of ultrahigh dose rate and oxygen concentration on the Fenton reaction using the Fricke solution. [PDF]

Med Phys
Chaoui M, Shin WG, Bouhali O, Schuemann J, Ramos-Méndez J, Tayalati Y.   +5 more
europepmc   +1 more source