Results 91 to 100 of about 2,071 (173)

Characterization of a Modified Clinical Linear Accelerator for Ultra-High Dose Rate Beam Delivery

Applied Sciences
Irradiations at Ultra-High Dose Rate (UHDR) regimes, exceeding 40 Gy/s in single fractions lasting less than 200 ms, have shown an equivalent antitumor effect compared to conventional radiotherapy with reduced harm to normal tissues.
Umberto Deut, Aurora Camperi, Cristiano Cavicchi, Roberto Cirio, Emanuele Maria Data, Elisabetta Alessandra Durisi, Veronica Ferrero, Arianna Ferro, Simona Giordanengo, Oscar Martì Villarreal, Felix Mas Milian, Elisabetta Medina, Diango M. Montalvan Olivares, Franco Mostardi, Valeria Monti, Roberto Sacchi, Edoardo Salmeri, Anna Vignati   +17 more
doaj   +1 more source

Commissioning a clinical proton pencil beam scanning beamline for pre-clinical ultra-high dose rate irradiations on a cyclotron-based system

Frontiers in Oncology
BackgroundThis manuscript describes modifications to a pencil beam scanning (PBS) proton gantry that enables ultra-high dose rates (UHDR) irradiation, including treatment planning and validation.MethodsBeamline modifications consisted of opening the ...
Jatinder Saini, Jatinder Saini, Danielle P. Johnson Erickson, François Vander Stappen, Matt Ruth, Matt Ruth, Sunan Cui, Sunan Cui, Vanessa Gorman, Séverine Rossomme, Ning Cao, Ning Cao, Eric C. Ford, Eric C. Ford, Juergen Meyer, Juergen Meyer, Charles Bloch, Charles Bloch, Tony Wong, Tony Wong, Clemens Grassberger, Ramesh Rengan, Ramesh Rengan, Jing Zeng, Jing Zeng, Marco Schwarz, Marco Schwarz   +26 more
doaj   +1 more source

X-Ray and Electron Beam Considerations for Laser-Compton Image-Guided Radiation Therapy [PDF]

Electron beams used in laser-Compton X-ray sources can be utilized as ultrahigh dose rate (UHDR) ionizing radiation sources if the architecture provides sufficient peak current and beam energy.
Reutershan, T, Nelson, EC, Hwang, Y, Effarah, HH, Barty, CPJ   +4 more
core   +1 more source

VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint

Scientific Reports
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied across several radiation modalities, including photons, protons and clinical energy electrons ...
Hannah C. Wanstall, Pierre Korysko, Wilfred Farabolini, Roberto Corsini, Joseph J. Bateman, Vilde Rieker, Abigail Hemming, Nicholas T. Henthorn, Michael J. Merchant, Elham Santina, Amy L. Chadwick, Cameron Robertson, Alexander Malyzhenkov, Roger M. Jones   +13 more
doaj   +1 more source

Scintillation Imaging as Versatile Tool for Validation of UHDR Treatment Plans Across Modalities

Journal of Physics, Conference Series
Scintillation imaging has been shown to provide high spatio-temporal surface dose information for delivery verification of ultra-high dose rate (UHDR) beams.
M. Clark, Roman Vasytlsiv, D. Gladstone, A. Mascia, J. Harms, P. Bruza   +5 more
semanticscholar   +1 more source

Systematic analysis of alanine/EPR pellets for reference dosimetry with UHDR electron beams for FLASH radiotherapy

Advancements in radiotherapy techniques, such as FLASH radiotherapy, in which ultra-high dose rates (UHDR) are applied, have set a challenge in investigating whether the standard dosimetric systems used in conventional radiotherapy can still be used ...
de Farias Soares, A., Milluzzo, G., Collura, G., Del Sarto, D., Felici, G., Marrale, M., D'Oca, M. C., Castronovo, E. R. A., Di Martino, F., Pensavalle, J. H., d'Errico, F., Romano, F., Masturzo, L.   +12 more
core   +1 more source

Solid-State Detector for FLASH Radiotherapy: Dosimetric Applications and Emerging Concepts

Condensed Matter
The implementation of FLASH Radiotherapy (FLASH-RT), characterized by ultra-high dose rates (UHDRs) frequently exceeding 106 Gy/s in microsecond pulses, imposes stringent requirements on real-time dosimetry. Conventional ionization chambers suffer severe
Pablo P. Yepes
doaj   +1 more source

Beam control system and output fine-tuning for safe and precise delivery of FLASH radiotherapy at a clinical linear accelerator

Frontiers in Oncology
IntroductionWe have previously adapted a clinical linear accelerator (Elekta Precise, Elekta AB) for ultra-high dose rate (UHDR) electron delivery.
Elise Konradsson, Pontus Wahlqvist, Andreas Thoft, Börje Blad, Börje Blad, Sven Bäck, Sven Bäck, Crister Ceberg, Kristoffer Petersson, Kristoffer Petersson   +9 more
doaj   +1 more source

Fast and Furious: Exploring the Potential of Ultra-High Dose Rate Heavy Ion Irradiation [PDF]

Radiation therapy is a cornerstone of cancer treatment, though its effectiveness is limited when treating radio-resistant, hypoxic, and motion-affected tumors, including pancreatic ductal adenocarcinoma (PDAC).
Karle, Celine
core   +1 more source

Review of oxygen measurement and relevance to the mechanisms of FLASH radiotherapy

Frontiers in Physics
FLASH radiotherapy (FLASH-RT) is the phenomenon of relative sparing of normal tissue when ultra-high dose rates (UHDR) are used compared with conventional dose rates (CDR) as clinically used.
Brian W. Pogue, Brian W. Pogue, Brian W. Pogue, David I. Hunter, Corbin Narita, William S. Thomas, Xu Cao, Harold M. Swartz, Harold M. Swartz   +8 more
doaj   +1 more source