Results 41 to 50 of about 480 (154)

Very high‐energy electron dose calculation using the Fermi‐Eyges theory of multiple scattering and a simplified pencil beam model

Medical Physics, Volume 50, Issue 12, Page 8009-8022, December 2023., 2023
Abstract Background Very high‐energy electrons (VHEE) radiotherapy, in the energy range of 100–200 MeV is currently considered a promising technique for the future of radiation therapy and could benefit from the promises of ultra‐high dose rate FLASH therapy.
Maria Grazia Ronga, Umberto Deut, Anthony Bonfrate, Ludovic De Marzi   +3 more
wiley   +1 more source

3D‐conformal very‐high energy electron therapy as candidate modality for FLASH‐RT: A treatment planning study for glioblastoma and lung cancer

Medical Physics, Volume 50, Issue 9, Page 5745-5756, September 2023., 2023
Abstract Background Pre‐clinical ultra‐high dose rate (UHDR) electron irradiations on time scales of 100 ms have demonstrated a remarkable sparing of brain and lung tissues while retaining tumor efficacy when compared to conventional dose rate irradiations.
Till Tobias Böhlen, Jean‐François Germond, Erik Traneus, Veronique Vallet, Laurent Desorgher, Esat Mahmut Ozsahin, François Bochud, Jean Bourhis, Raphaël Moeckli   +8 more
wiley   +1 more source

Nanoscopic biodosimetry using plasmid DNA in radiotherapy with metallic nanoparticles

Journal of Applied Clinical Medical Physics, Volume 24, Issue 2, February 2023., 2023
Abstract Nanoscopic lesions (complex damages), are the most lethal lesions for the cells. As nanoparticles have become increasingly popular in radiation therapy and the importance of analyzing nanoscopic dose enhancement has increased, a reliable tool for nanodosimetry has become indispensable. In this regard, the DNA plasmid is a widely used tool as a
Elham Mansouri, Asghar Mesbahi, Mohammad Saied Hejazi, Soheila Montazersaheb, Vahideh Tarhriz, Tohid Ghasemnejad, Mojtaba Zarei   +6 more
wiley   +1 more source

Back to the Future: Very High-Energy Electrons (VHEEs) and Their Potential Application in Radiation Therapy [PDF]

Cancers, 2021
The development of innovative approaches that would reduce the sensitivity of healthy tissues to irradiation while maintaining the efficacy of the treatment on the tumor is of crucial importance for the progress of the efficacy of radiotherapy. Recent methodological developments and innovations, such as scanned beams, ultra-high dose rates, and very ...
Ronga, Maria Grazia, Cavallone, Marco, Patriarca, Annalisa, Leite, Amelia Maia, Loap, Pierre, Favaudon, Vincent, Créhange, Gilles, de Marzi, Ludovic   +7 more
openaire   +2 more sources

A potential revolution in cancer treatment: A topical review of FLASH radiotherapy

Journal of Applied Clinical Medical Physics, Volume 23, Issue 10, October 2022., 2022
Abstract FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR) (≥40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies show that the UHDR RT has the potential to spare normal tissue without sacrificing tumor control.
Yuan Gao, Ruirui Liu, Chih‐Wei Chang, Serdar Charyyev, Jun Zhou, Jeffrey D. Bradley, Tian Liu, Xiaofeng Yang   +7 more
wiley   +1 more source

Modification of the Microstructure of the CERN- CLEAR-VHEE Beam at the Picosecond Scale Modifies ZFE Morphogenesis but Has No Impact on Hydrogen Peroxide Production

Radiotherapy and Oncology
Wilfrid Farabolini, Jonathan Ollivier
exaly   +2 more sources

Ultra‐high dose rate radiation production and delivery systems intended for FLASH

Medical Physics, Volume 49, Issue 7, Page 4875-4911, July 2022., 2022
Abstract Higher dose rates, a trend for radiotherapy machines, can be beneficial in shortening treatment times for radiosurgery and mitigating the effects of motion. Recently, even higher doses (e.g., 100 times greater) have become targeted because of their potential to generate the FLASH effect (FE). We refer to these physical dose rates as ultra‐high
Jonathan Farr, Veljko Grilj, Victor Malka, Srinivasan Sudharsan, Marco Schippers   +4 more
wiley   +1 more source

A novel fibre optic monitor for VHEE UHDR beam monitoring: first tests at CLEAR

, 2023
Beam monitoring for Ultra High Dose Rate (UHDR) radiation therapy using pulsed beams, i.e. Very High Energy Electrons (VHEE), is a major challenge. The lower pulse repetition of VHEE beams means a larger dose-per-pulse is necessary to achieve the mean ...
Ortega Ruiz, Inaki, Dosanjh, Manjit, Bateman, Joseph, Farabolini, Wilfrid, Corsini, Roberto, Malyzhenkov, Alexander, Korysko, Pierre, Buchanan, Emma, Rieker, Vilde, Gerbershagen, Alexander   +9 more
core   +1 more source

Treatment planning of intracranial lesions with VHEE: comparing conventional and FLASH irradiation potential with state-of-the-art photon and proton radiotherapy

Frontiers in Physics, 2023
The treatment of deep-seated tumours with electrons of very high energies (VHEE, 70–150 MeV) has already been explored in the past, suggesting that a dosimetric coverage comparable with state-of-the-art proton (PT) or photon radiotherapy (RT) could be ...
A. Muscato, A. Muscato, A. Muscato, L. Arsini, L. Arsini, G. Battistoni, L. Campana, D. Carlotti, D. Carlotti, F. De Felice, A. De Gregorio, A. De Gregorio, M. De Simoni, M. De Simoni, C. Di Felice, Y. Dong, G. Franciosini, G. Franciosini, M. Marafini, M. Marafini, I. Mattei, R. Mirabelli, R. Mirabelli, S. Muraro, M. Pacilio, L. Palumbo, L. Palumbo, V. Patera, V. Patera, A. Schiavi, A. Schiavi, A. Sciubba, A. Sciubba, M. Schwarz, S. Sorbino, V. Tombolini, M. Toppi, M. Toppi, G. Traini, A. Trigilio, A. Trigilio, A. Sarti, A. Sarti   +42 more
doaj   +1 more source

Determination of the ion collection efficiency of the Razor Nano Chamber for ultra‐high dose‐rate electron beams

Medical Physics, Volume 49, Issue 7, Page 4731-4742, July 2022., 2022
Abstract Background Ultra‐high dose‐rate (UHDR) irradiations (>40 Gy/s) have recently garnered interest in radiotherapy (RT) as they can trigger the so‐called “FLASH” effect, namely a higher tolerance of normal tissues in comparison with conventional dose rates when a sufficiently high dose is delivered to the tissue.
Marco Cavallone, Patrik Gonçalves Jorge, Raphaël Moeckli, Claude Bailat, Alessandro Flacco, Yolanda Prezado, Rachel Delorme   +6 more
wiley   +1 more source