Results 41 to 50 of about 381 (150)

Computational study of the effect of focusing on VHEE radiotherapy [PDF]

, 2023
Cancer is an increasingly relevant public health problem on the world stage. For it’s treatment, some types of radiotherapy are used, in order to deliver, through the use of beams of ionizing radiation, a quantity of dose in the tumor region while ...
Brum, Fábio Lunelli da Silva
core   +2 more sources

An experimental study of focused very high energy electron beams for radiotherapy

Communications Physics, 2021
Very high energy electrons (VHEE) penetrate deeply in tissues and can provide an alternative to photon irradiation for tumour treatment. Using VHEE beams at CERN Linear Electron Accelerator for Research (CLEAR) focused into a water phantom, the authors ...
Karolina Kokurewicz, Enrico Brunetti, Alessandro Curcio, Davide Gamba, Luca Garolfi, Antonio Gilardi, Eugenio Senes, Kyrre Ness Sjobak, Wilfrid Farabolini, Roberto Corsini, Dino Anthony Jaroszynski   +10 more
doaj   +1 more source

Modification of the microstructure of the CERN- CLEAR-VHEE beam at the picosecond scale modifies ZFE morphogenesis but has no impact on hydrogen peroxide production

Radiotherapy and Oncology
Jonathan Ollivier, Wilfrid Farabolini
exaly   +2 more sources

Very high‐energy electron dose calculation using the Fermi‐Eyges theory of multiple scattering and a simplified pencil beam model

Medical Physics, Volume 50, Issue 12, Page 8009-8022, December 2023., 2023
Abstract Background Very high‐energy electrons (VHEE) radiotherapy, in the energy range of 100–200 MeV is currently considered a promising technique for the future of radiation therapy and could benefit from the promises of ultra‐high dose rate FLASH therapy.
Maria Grazia Ronga, Umberto Deut, Anthony Bonfrate, Ludovic De Marzi   +3 more
wiley   +1 more source

3D‐conformal very‐high energy electron therapy as candidate modality for FLASH‐RT: A treatment planning study for glioblastoma and lung cancer

Medical Physics, Volume 50, Issue 9, Page 5745-5756, September 2023., 2023
Abstract Background Pre‐clinical ultra‐high dose rate (UHDR) electron irradiations on time scales of 100 ms have demonstrated a remarkable sparing of brain and lung tissues while retaining tumor efficacy when compared to conventional dose rate irradiations.
Till Tobias Böhlen, Jean‐François Germond, Erik Traneus, Veronique Vallet, Laurent Desorgher, Esat Mahmut Ozsahin, François Bochud, Jean Bourhis, Raphaël Moeckli   +8 more
wiley   +1 more source

Nanoscopic biodosimetry using plasmid DNA in radiotherapy with metallic nanoparticles

Journal of Applied Clinical Medical Physics, Volume 24, Issue 2, February 2023., 2023
Abstract Nanoscopic lesions (complex damages), are the most lethal lesions for the cells. As nanoparticles have become increasingly popular in radiation therapy and the importance of analyzing nanoscopic dose enhancement has increased, a reliable tool for nanodosimetry has become indispensable. In this regard, the DNA plasmid is a widely used tool as a
Elham Mansouri, Asghar Mesbahi, Mohammad Saied Hejazi, Soheila Montazersaheb, Vahideh Tarhriz, Tohid Ghasemnejad, Mojtaba Zarei   +6 more
wiley   +1 more source

Ultra‐high dose rate radiation production and delivery systems intended for FLASH

Medical Physics, Volume 49, Issue 7, Page 4875-4911, July 2022., 2022
Abstract Higher dose rates, a trend for radiotherapy machines, can be beneficial in shortening treatment times for radiosurgery and mitigating the effects of motion. Recently, even higher doses (e.g., 100 times greater) have become targeted because of their potential to generate the FLASH effect (FE). We refer to these physical dose rates as ultra‐high
Jonathan Farr, Veljko Grilj, Victor Malka, Srinivasan Sudharsan, Marco Schippers   +4 more
wiley   +1 more source

Evaluating VHEE radiotherapy treatment plans for prostate and lung cancer [PDF]

, 2023
Over 50% of cancer patients will receive radiotherapy treatment at least once. Most patients are receiving photon radiotherapy. In this work very high energy electron (VHEE) radiotherapy is being studied as a potential replacement for photon radiotherapy.
Spek, Bob (author)
core  

Determination of the ion collection efficiency of the Razor Nano Chamber for ultra‐high dose‐rate electron beams

Medical Physics, Volume 49, Issue 7, Page 4731-4742, July 2022., 2022
Abstract Background Ultra‐high dose‐rate (UHDR) irradiations (>40 Gy/s) have recently garnered interest in radiotherapy (RT) as they can trigger the so‐called “FLASH” effect, namely a higher tolerance of normal tissues in comparison with conventional dose rates when a sufficiently high dose is delivered to the tissue.
Marco Cavallone, Patrik Gonçalves Jorge, Raphaël Moeckli, Claude Bailat, Alessandro Flacco, Yolanda Prezado, Rachel Delorme   +6 more
wiley   +1 more source

Standard‐space atlas of the viscoelastic properties of the human brain

Human Brain Mapping, Volume 41, Issue 18, Page 5282-5300, December 15, 2020., 2020
Tissue mechanical properties provide a macroscopic representation of the microstructural constituents of soft biological tissue. In the work, we have produced the first standard‐space atlas description of the stiffness and damping ratio of the healthy human brain. The detailed nature of the new atlas has revealed that neuroanatomical structures possess
Lucy V. Hiscox, Matthew D. J. McGarry, Hillary Schwarb, Elijah E. W. Van Houten, Ryan T. Pohlig, Neil Roberts, Graham R. Huesmann, Agnieszka Z. Burzynska, Bradley P. Sutton, Charles H. Hillman, Arthur F. Kramer, Neal J. Cohen, Aron K. Barbey, Keith D. Paulsen, Curtis L. Johnson   +14 more
wiley   +1 more source