Results 21 to 30 of about 381 (150)

Treatment planning comparison of focused very high energy electron and volumetric modulated arc therapy [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Very high energy electron (VHEE) radiotherapy gained interest owing to technical advances and its potential for FLASH radiotherapy.
Florian Amstutz, Chengchen Zhu, Werner Volken, Hannes A. Loebner, Silvan Mueller, Sascha Frei, Jenny Bertholet, Peter Manser, Michael K. Fix   +8 more
doaj   +2 more sources

Implementation and validation of a very-high-energy electron model in the matRad treatment planning system. [PDF]

Med Phys
Abstract Background While electron beams of up to 20 MeV are commonly used in radiotherapy, the use of very‐high‐energy electrons (VHEEs) in the range of 100–200 MeV is now becoming a realistic option thanks to the recent advancements in accelerator technology.
Sitarz M, Ronga MG, Gesualdi F, Bonfrate A, Wahl N, De Marzi L.   +5 more
europepmc   +2 more sources

Status of VHEE Radiotherapy Related Studies at the CLEAR User Facility at CERN [PDF]

, 2021
Despite the increase in interest in using Very High Energy Electron (VHEE) beams for cancer radiotherapy many unanswered questions in its development remain. The use of test facilities will be an essential tool used to solve these issues. The 200 MeV electron beam from the CERN Linear Accelerator for Research (CLEAR) has been used extensively, in ...
Corsini, Roberto, Dyks, Luke, Farabolini, Wilfrid, Gilardi, Antonio, Korysko, Pierre, Sjobak, Kyrre   +5 more
openaire   +3 more sources

Preclinical tumor control with a laser-accelerated high-energy electron radiotherapy prototype [PDF]

Nature Communications
Radiotherapy using very-high-energy electron (VHEE) beams (50-300 MeV) has attracted considerable attention due to its advantageous dose deposition characteristics, enabling deep penetration and easy manipulation by magnetic components.
Zhiyuan Guo, Shuang Liu, Bing Zhou, Junqi Liu, Haiyang Wang, Yifei Pi, Xiaoyan Wang, Yingyi Mo, Bo Guo, Jianfei Hua, Yang Wan, Wei Lu   +11 more
doaj   +2 more sources

Development and validation of a novel pulse optimization and beam control system for conventional and ultra high dose-per-pulse (FLASH) irradiation. [PDF]

Med Phys
Abstract Background FLASH radiotherapy requires precise control and minimal variation of dose per pulse (DPP). However, clinical linear accelerators and their beam control systems are designed to ensure accuracy of the temporally integrated dose and do not control for transient variations in DPP during radiation delivery.
Connell L, Esplen N, Lim R, Baikalov A, Coupey N, Nguyen C, Schüler E.   +6 more
europepmc   +2 more sources

Consensus statement on the exploration of clinical translation and application of electron ultra-high dose rate FLASH radiotherapy. [PDF]

Precis Radiat Oncol
• FLASH‐RT as a novel irradiation technique shows a protective effect on normal tissues while maintaining comparable tumor killing effect as CONV‐RT, also known as the FLASH effect. • We develop a consensus statement on the exploration of clinical translation of FLASH‐RT, and provide insights for the further application of this technology in clinical ...
Luo H, Yang C, Yue J, Ge H.
europepmc   +2 more sources

A potential revolution in cancer treatment: A topical review of FLASH radiotherapy. [PDF]

J Appl Clin Med Phys, 2022
Abstract FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR) (≥40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies show that the UHDR RT has the potential to spare normal tissue without sacrificing tumor control.
Gao Y, Liu R, Chang CW, Charyyev S, Zhou J, Bradley JD, Liu T, Yang X.   +7 more
europepmc   +2 more sources

Review of VHEE Beam Energy Evolution for FLASH Radiation Therapy Under Ultra-High Dose Rate (UHDR) Dosimetry [PDF]

Quantum Beam Science
Very-high-energy electron (VHEE) beams, ranging from 50 to 300 or 400 MeV, are the subject of intense research investigation, with considerable interest concerning applications in radiation therapy due to their accurate energy deposition into large and ...
Nikolaos Gazis, Evangelos Gazis
doaj   +2 more sources

Back to the Future: Very High-Energy Electrons (VHEEs) and Their Potential Application in Radiation Therapy. [PDF]

Cancers (Basel), 2021
The development of innovative approaches that would reduce the sensitivity of healthy tissues to irradiation while maintaining the efficacy of the treatment on the tumor is of crucial importance for the progress of the efficacy of radiotherapy. Recent methodological developments and innovations, such as scanned beams, ultra-high dose rates, and very ...
Ronga MG, Cavallone M, Patriarca A, Leite AM, Loap P, Favaudon V, Créhange G, De Marzi L.   +7 more
europepmc   +4 more sources

Treatment planning of intracranial lesions with VHEE: comparing conventional and FLASH irradiation potential with state-of-the-art photon and proton radiotherapy [PDF]

Frontiers in Physics, 2023
The treatment of deep-seated tumours with electrons of very high energies (VHEE, 70–150 MeV) has already been explored in the past, suggesting that a dosimetric coverage comparable with state-of-the-art proton (PT) or photon radiotherapy (RT) could be ...
A. Muscato, A. Muscato, A. Muscato, L. Arsini, L. Arsini, G. Battistoni, L. Campana, D. Carlotti, D. Carlotti, F. De Felice, A. De Gregorio, A. De Gregorio, M. De Simoni, M. De Simoni, C. Di Felice, Y. Dong, G. Franciosini, G. Franciosini, M. Marafini, M. Marafini, I. Mattei, R. Mirabelli, R. Mirabelli, S. Muraro, M. Pacilio, L. Palumbo, L. Palumbo, V. Patera, V. Patera, A. Schiavi, A. Schiavi, A. Sciubba, A. Sciubba, M. Schwarz, S. Sorbino, V. Tombolini, M. Toppi, M. Toppi, G. Traini, A. Trigilio, A. Trigilio, A. Sarti, A. Sarti   +42 more
doaj   +3 more sources