Results 21 to 30 of about 11,945,723 (183)
Counterion Dependent Side‐Chain Relaxation Stiffens a Chemically Doped Thienothiophene Copolymer
Advanced Functional Materials, EarlyView.Oxidation of a thienothiophene copolymer, p(g3TT‐T2), via different doping strategies and dopant molecules resulted in materials with similar oxidation levels and a high electrical conductivity of ≈100 S cm−1. However, mechanical properties varied significantly, with sub‐glass transition temperatures and elastic moduli spanning from –44°C to –3°C and ...Mariavittoria Craighero, Meghna Jha, Elsa Veronica Flores‐Vela, Joost Kimpel, Andreas Schaefer, Jiali Guo, Jesika Asatryan, Alberto Peinador Veiga, Shuichi Haraguchi, Per‐Anders Carlsson, Jaime Martín, Mariano Campoy‐Quiles, Christian Müller +12 morewiley +1 more sourceResistance to Overdoping Allows Over 2000 S cm−1 Conductivity in P(g3BTTT) With Anion‐Exchange Doping
Advanced Materials, EarlyView.Anion‐exchange doping of conjugated polymers is an effective way to achieve high conductivities. Here, we report over 2000 S cm−1 electrical conductivity for doped P(g3BTTT). In addition, we show that P(g3BTTT) sustains exceptionally high doping levels without any drop in the charge mobility.Basil Hunger, Maximilian M. Horn, Eva Röck, Diego Rosas Villalva, Lize Bynens, Jochen Vanderspikken, Christina Kousseff, Silène Gobeil, Olivier Bardagot, Nesibe Akmanşen‐Kalayci, Sarah H. Tolbert, Iain McCulloch, Wouter Maes, Demetra Tsokkou, Natalie Banerji +14 morewiley +1 more sourcePenfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
Advanced Science, EarlyView.A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng +11 morewiley +1 more sourceThe NANOGrav 15 yr Dataset: Improved Timing Precision with Very Long Baseline Interferometry Astrometric Priors
The Astrophysical JournalAccurate pulsar astrometric estimates are essential to almost all high-precision pulsar timing experiments. Traditional pulsar timing techniques refine these estimates by including them as free parameters when fitting a model to observed pulse time-of ...Sofia V. Sosa Fiscella, Michael T. Lam, Gabriella Agazie, Akash Anumarlapudi, Anne M. Archibald, Zaven Arzoumanian, Paul T. Baker, Paul R. Brook, H. Thankful Cromartie, Kathryn Crowter, María Silvina De Biasi, Megan E. DeCesar, Paul B. Demorest, Timothy Dolch, Elizabeth C. Ferrara, William Fiore, Emmanuel Fonseca, Gabriel E. Freedman, Nate Garver-Daniels, Peter A. Gentile, Joseph Glaser, Deborah C. Good, Jeffrey S. Hazboun, Ross J. Jennings, Megan L. Jones, David L. Kaplan, Matthew Kerr, Duncan R. Lorimer, Jing Luo, Ryan S. Lynch, Alexander McEwen, Maura A. McLaughlin, Natasha McMann, Bradley W. Meyers, Cherry Ng, David J. Nice, Timothy T. Pennucci, Benetge B. P. Perera, Nihan S. Pol, Henri A. Radovan, Scott M. Ransom, Paul S. Ray, Ann Schmiedekamp, Carl Schmiedekamp, Brent J. Shapiro-Albert, Ingrid H. Stairs, Kevin Stovall, Abhimanyu Susobhanan, Joseph K. Swiggum, Haley M. Wahl +49 moredoaj +1 more sourceA Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe +12 morewiley +1 more sourceVery long baseline interferometry [PDF]
, 1973 S-band stations with dual tracking capability have been used to gather double differential very long baseline interferometry data on Apollo 16 and Apollo 17.Salzberg, I. M.core Atmospheric Limitations for High-frequency Ground-based Very Long Baseline Interferometry
The Astrophysical JournalVery long baseline interferometry (VLBI) provides the highest-resolution images in astronomy. The sharpest resolution is nominally achieved at the highest frequencies, but as the observing frequency increases, so too does the atmospheric contribution to ...Dominic W. Pesce, Lindy Blackburn, Ryan Chaves, Sheperd S. Doeleman, Mark Freeman, Sara Issaoun, Michael D. Johnson, Greg Lindahl, Iniyan Natarajan, Scott N. Paine, Daniel C. M. Palumbo, Freek Roelofs, Paul Tiede +12 moredoaj +1 more sourceCancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck +9 morewiley +1 more sourceFirst Very Long Baseline Interferometry Detections at 870 μm
The Astronomical JournalThe first very long baseline interferometry (VLBI) detections at 870 μ m wavelength (345 GHz frequency) are reported, achieving the highest diffraction-limited angular resolution yet obtained from the surface of the Earth and the highest-frequency ...Alexander W. Raymond, Sheperd S. Doeleman, Keiichi Asada, Lindy Blackburn, Geoffrey C. Bower, Michael Bremer, Dominique Broguiere, Ming-Tang Chen, Geoffrey B. Crew, Sven Dornbusch, Vincent L. Fish, Roberto García, Olivier Gentaz, Ciriaco Goddi, Chih-Chiang Han, Michael H. Hecht, Yau-De Huang, Michael Janssen, Garrett K. Keating, Jun Yi Koay, Thomas P. Krichbaum, Wen-Ping Lo, Satoki Matsushita, Lynn D. Matthews, James M. Moran, Timothy J. Norton, Nimesh Patel, Dominic W. Pesce, Venkatessh Ramakrishnan, Helge Rottmann, Alan L. Roy, Salvador Sánchez, Remo P. J. Tilanus, Michael Titus, Pablo Torne, Jan Wagner, Jonathan Weintroub, Maciek Wielgus, André Young, Kazunori Akiyama, Ezequiel Albentosa-Ruíz, Antxon Alberdi, Walter Alef, Juan Carlos Algaba, Richard Anantua, Rebecca Azulay, Uwe Bach, Anne-Kathrin Baczko, David Ball, Mislav Balokovic, Bidisha Bandyopadhyay, John Barrett, Michi Bauböck, Bradford A. Benson, Dan Bintley, Raymond Blundell, Katherine L. Bouman, Hope Boyce, Roger Brissenden, Silke Britzen, Avery E. Broderick, Thomas Bronzwaer, Sandra Bustamante, John E. Carlstrom, Andrew Chael, Chi-kwan Chan, Dominic O. Chang, Koushik Chatterjee, Shami Chatterjee, Yongjun Chen, Xiaopeng Cheng, Ilje Cho, Pierre Christian, Nicholas S. Conroy, John E. Conway, Thomas M. Crawford, Alejandro Cruz-Osorio, Yuzhu Cui, Rohan Dahale, Jordy Davelaar, Mariafelicia De Laurentis, Roger Deane, Jessica Dempsey, Gregory Desvignes, Jason Dexter, Vedant Dhruv, Indu K. Dihingia, Sergio A. Dzib, Ralph P. Eatough, Razieh Emami, Heino Falcke, Joseph Farah, Edward Fomalont, Anne-Laure Fontana, H. Alyson Ford, Marianna Foschi, Raquel Fraga-Encinas, William T. Freeman, Per Friberg, Christian M. Fromm, Antonio Fuentes, Peter Galison, Charles F. Gammie, Boris Georgiev, Roman Gold, Arturo I. Gómez-Ruiz, José L. Gómez, Minfeng Gu, Mark Gurwell, Kazuhiro Hada, Daryl Haggard, Ronald Hesper, Dirk Heumann, Luis C. Ho, Paul Ho, Mareki Honma, Chih-Wei L. Huang, Lei Huang, David H. Hughes, Shiro Ikeda, C. M. Violette Impellizzeri, Makoto Inoue, Sara Issaoun, David J. James, Buell T. Jannuzi, Britton Jeter, Wu Jiang, Alejandra Jiménez-Rosales, Michael D. Johnson, Svetlana Jorstad, Adam C. Jones, Abhishek V. Joshi, Taehyun Jung, Ramesh Karuppusamy, Tomohisa Kawashima, Mark Kettenis, Dong-Jin Kim, Jae-Young Kim, Jongsoo Kim, Junhan Kim, Motoki Kino, Prashant Kocherlakota, Yutaro Kofuji, Patrick M. Koch, Shoko Koyama, Carsten Kramer, Joana A. Kramer, Michael Kramer, Derek Kubo, Cheng-Yu Kuo, Noemi La Bella, Sang-Sung Lee, Aviad Levis, Zhiyuan Li, Rocco Lico, Greg Lindahl, Michael Lindqvist, Mikhail Lisakov, Jun Liu, Kuo Liu, Elisabetta Liuzzo, Andrei P. Lobanov, Laurent Loinard, Colin J. Lonsdale, Amy E. Lowitz, Ru-Sen Lu, Nicholas R. MacDonald, Sylvain Mahieu, Doris Maier, Jirong Mao, Nicola Marchili, Sera Markoff, Daniel P. Marrone, Alan P. Marscher, Iván Martí-Vidal, Lia Medeiros, Karl M. Menten, Izumi Mizuno, Yosuke Mizuno, Joshua Montgomery, Kotaro Moriyama, Monika Moscibrodzka, Wanga Mulaudzi, Cornelia Müller, Hendrik Müller, Alejandro Mus, Gibwa Musoke, Ioannis Myserlis, Hiroshi Nagai, Neil M. Nagar, Masanori Nakamura, Gopal Narayanan, Iniyan Natarajan, Antonios Nathanail, Santiago Navarro Fuentes, Joey Neilsen, Chunchong Ni, Michael A. Nowak, Junghwan Oh, Hiroki Okino, Héctor Raúl Olivares Sánchez, Tomoaki Oyama, Feryal Özel, Daniel C. M. Palumbo, Georgios Filippos Paraschos, Jongho Park, Harriet Parsons, Ue-Li Pen, Vincent Piétu, Aleksandar PopStefanija, Oliver Porth, Ben Prather, Giacomo Principe, Dimitrios Psaltis, Hung-Yi Pu, Philippe A. Raffin, Ramprasad Rao, Mark G. Rawlings, Angelo Ricarte, Bart Ripperda, Freek Roelofs, Cristina Romero-Cañizales, Eduardo Ros, Arash Roshanineshat, Ignacio Ruiz, Chet Ruszczyk, Kazi L. J. Rygl, David Sánchez-Argüelles, Miguel Sánchez-Portal, Mahito Sasada, Kaushik Satapathy, Tuomas Savolainen, F. Peter Schloerb, Jonathan Schonfeld, Karl-Friedrich Schuster, Lijing Shao, Zhiqiang Shen, Des Small, Bong Won Sohn, Jason SooHoo, León David Sosapanta Salas, Kamal Souccar, Ranjani Srinivasan, Joshua S. Stanway, He Sun, Fumie Tazaki, Alexandra J. Tetarenko, Paul Tiede, Kenji Toma, Teresa Toscano, Efthalia Traianou, Tyler Trent, Sascha Trippe, Matthew Turk, Ilse van Bemmel, Huib Jan van Langevelde, Daniel R. van Rossum, Jesse Vos, Derek Ward-Thompson, John Wardle, Jasmin E. Washington, Robert Wharton, Kaj Wiik, Gunther Witzel, Michael F. Wondrak, George N. Wong, Qingwen Wu, Nitika Yadlapalli, Paul Yamaguchi, Aristomenis Yfantis, Doosoo Yoon, Ziri Younsi, Wei Yu, Feng Yuan, Ye-Fei Yuan, J. Anton Zensus, Shuo Zhang, Guang-Yao Zhao, Shan-Shan Zhao +278 moredoaj +1 more source
